"Azathioprine": diiwaanka, dib u eegista, sharaxaada, analogs

Kaas oo ku baaqay in daroogada "azathioprine"? Tilmaamaha on codsiga ay soo gudbiyeen wakiilada lagu tilmaami doonaa in this article. Waxa kale oo aanu kuu sheegi haddii ay jiraan sababo iyo analogues leeyihiin daroogada this, waxa ay kukacayaan, waxa dhici doona hadii aad iska badisid ah, iyo wixii la mid ah. d.

Curiska, baakadaha, qaabka, description medicament

In waxa foomka waa daroogada la heli karo "azathioprine"? Tilmaamaha loogu isticmaalo jeedisay in dawadan waxa laga helayaa in kiniin. Ay qayb firfircoon u dhaqmo sida azathioprine. Sidoo kale daroogada iyo waxaa ka mid ah maaddooyinka kale oo dheeraad ah oo ah qaab istaarijka baradho, gelatin, lactose, oo ku milmahayn calcium.

In xirmo iibin daroogada "azathioprine"? Tilmaamaha loogu isticmaalo daroogada waxaa ku jira kartoon ah, kaas oo kaalinta kiniinka Valium midab jaalle midab in baakad fin of 50 xabbadood.

sifooyinka pharmacological of medicament ah

Waa maxay daawada sida "azathioprine"? Tilmaamaha loogu isticmaalo, khibrad iyo xirfad dhab ah in daroogada ee su'aasha waa analog ah "hypoxanthine", "adenayn" iyo "gu'anayn", waxaa ka mid ah in qaab-dhismeedka acids nucleic iyo muujiyaan saamayn ku furid ee la xiriirta kororka nudaha iyo qeybinta unug a.

"Azathioprine" - Wakiilka jirka. Its tallaabo loogu talagalay cytotoxicity gacanta.

Waxaa loo tixgeliyaa daroogada ay awoodaan in ay la xakameeyo falcelinta ee incompatibility nudaha iyo saamayn taranka ee unugyada, laakiin kaliya ilaa xad yar. Marka la barbar dhigo "mercaptopurine" daroogada firfircoon muujinayaa a more fahmayaan.

daroogada Pharmacokinetic

Ka dib markii daroogada afka si fiican u nuugo ka soo mareenka caloosha iyo mindhicirka. Waxay leedahay bond hoose la borotiinada plasma (qiyaastii 30%).

biotransformation ee saamaxaaddu daroogada kaaga acid tioinozinovoy iyo mercaptopurine (i.e., metabolite firfircoon). Inta ay yar oo daawada nudaha. Xaaladdan oo kale, fiirsashada yar oo ah daroogada laga helo maskaxda.

The bar-nolosha ee azathioprine, iyo metabolites ay firfircoon yahay oo ku saabsan 6 saacadood. tirada ugu badan ee daawada dhiigga ku arkay 70-110 daqiiqo ka dib.

Daawada waxaa ku dhowaad si buuxda u wada saaray la bile, iyo 1-2 oo kaliya% - by kelyaha.

Tilmaamayaasha kiniiniyada

Maxaa qorayaasha "azathioprine" (tilmaamaha isticmaalka daroogada, analogs, dib u eegista lagu soo bandhigi doonaa ka dib)? diyaarinta Tani waxay u muuqato wax ku ool ah marka aan caadi ahayn soo socda:

• psoriasis,
• arthritis rheumatoid;
• lupus erythematosus oo nidaamsan oo cas ;
• ulcerös kolit;
• dermatomyositis;
• daweeyay gravis;
• suuqnimo Pemphigus;
• periarteritis nodosa;
• cudurka Crohn ;
• glomerulonephritis, shalalka,
• hepatitis firfircoon chronic;
• Reiter ee syndrome ,
• purpura thrombocytopenic idiopathic.

Sidoo kale waa in la ogaadaa in daawaynta this waxaa badanaa loo qoray, waayo, ka hortaga diidmada xubin. Laakiin haddii ay taasi waxaa lala qaato dawooyinka kale.

Sababo isticmaalka daroogada

Tilmaamaha loogu isticmaalo daroogada "azathioprine" ku wargelinaysaa bukaanada ku saabsan sababo soo socda:

• failure cagaarshowga ;
• diidmo in daawo qaybaha firfircoon ama kaabayaal ah,
• inta aad uurka leedahay,
• xaaladda hematopoiesis la dulmay,
• da'da carruurta;
• naas-nuujinta.

Medicament "azathioprine": Qiyaasta iyo maamulka

Qaado kiniin "azathioprine" waa in la maamulo kaliya hadal. Xaalad kasta, qiyaasta daawada waa shaqsi goostay, iyadoo ku xiran helitaanka cadeymaha, iyo sidoo kale heerka uu gaarsiisan yahay cudurka iyo daaweynta ay saameen.

Waayo, ka hortagga daawo diidmada jab qoray isku dhafan oo "cyclosporin" iyo corticosteroids. Bilowga qaadashada daaweynta daawada ee dose loading waa 5 mg halkii kg (in ka badan laba bilood) a. Ka dibna waxa ay qaataan daawada ee dose dayactirka (1-4 mg halkii kg 3 qaadasho). Sida caadiga ah, daaweynta sida waxaa sii waqti dheer. Hadii aad joojisid dose therapy daawada loo dhigi si tartiib tartiib ah.

At dhacdo ka mid ah calaamadaha ugu horreeya ee diidmada xubnaha transplanted waxaa loo baahan yahay in mar kale loo kordhiyo qiyaasta maalinlaha ah ee medicament ilaa 4 mg halkii kg.

Waayo, daawaynta cudurada medicament kale si caadi ah u maamula ee dose maalinle ah oo 1.5-2 mg halkii kg ilaa 4 qaadasho kala qaybsan. Haddii loo baahdo, lacagta ku qeexan ee daroogada waxa lagu kordhin karaa in 200-250 mg (qaybsan 4 qaadasho). Muddada aad daawada la qalab waxaa loo dhigay si gaar ah, ku takhasusay khibrad leh.

Sida loo isticmaalo "azathioprine" (kiniin) ee rheumatoid arthritis? Tilmaamaha loogu isticmaalo, ratings (diyaarinta tilmaamay waxaa ku xusan soo bandhigay) waxa uu dhigayaa in lagu daweeyo cudurada sida qoray 1-2.5 mg halkii kg maalintii (qaybsan 2 qiyaasood). Duration ee therapy waa inuu ugu yaraan 3 bilood. Sida ay taageertaa bukaanka waxaa la siiyaa qiyaas 0.5 mg halkii kg (dose hal).

Waayo, daaweynta cagaarshowga B ee joogtada ah (firfircoon) qori dose maalinle ah oo 1-1.5 mg halkii kg.

Kiisaska of badinta daroogada

Waa maxay calaamadaha ah qiyaasta xad dhaafka dhacaan dhaweynta qaldan "azathioprine" daroogada? Tilmaamaha loogu isticmaalo, dhakhaatiir khibrad dhab ah in qiyaasta sare ee daroogada waxay keeni kartaa gobolka dyspeptic kala duwan, pancytopenia, xanuunada hawlaha beerka iyo xoojinta saamaynta kale dhinaca of daroogada.

Sida daaweynta ifafaale sida isticmaalaya therapy astaamaha. Haddii loo baahdo, kelyaha. Si kastaba ha ahaatee, in ay ogaadaan in nidaamkan, ma aha ballanqaad in xididada loo dhamaystiran oo ah walaxda firfircoon jidhka ka.

isdhexgalka daroogada

Sida daroogooyinka kale saamayn ku daroogada "azathioprine"? Tilmaamaha loogu isticmaalo wadamada in wada-maamulka ee wakiilka la "Allopurinol" kobcin kara saamaynta sun ah ee ugu horeysay, iyo in lala ah "co-trimoxazole" inta badan keenta in kordhay saamaynta myelotoxic.

daaweynta isku mar la celiyeyaasha ACE kordhiyaa halista ah ee leukopenia daran.

Isku dhafan oo immunosuppressants kale (tus, "Cyclosporins", glucocorticoids, unugyada anti-CD3) marar aad u leedahay noocyo kala duwan oo neoplasms iyo cudurada.

diyaarinta viewed muujinayaa saamayn nidaaam in nedepolyarizuyushim dabcineyso muruqa.

Sidoo kale waa in la ogaadaa in tallaalka lagu jiro daaweynta "azathioprine" si sahal ah waxay keeni kartaa in xakamaynta ee wax soo saarka ee antibodies (lacala tallaalka fayruska aan nooleyn), iyo sidoo kale kordhin taranka viral (la hordhaca ah ee tallaal nool).

talooyin gaar ah

Waxayaabaha ah inaad ogaato ka hor inta aadan qoro dawooyinka "azathioprine"? Tilmaamaha loogu isticmaalo, dhabta ah (daawooyinka analogues hoos ku qoran) Dawladdu in inta lagu jiro labada bilood ee ugu horeeya daaweynta ayaa loo baahan yahay todobaad kasta si ay u dhawraan qaabka dhiig durugsan. Ka dib wakhtigan, sidu muujiyay baadhitaanku ka kooban oo la soo noqnoqoshada ah 1 30 maalmood oo kasta.

Waxa kale oo lagama maarmaan ah in lala socdo heerka bilirubin, phosphatase xumadoodu iyo falgalka beerka.

In joogitaanka aan caadi ahayn of kelyaha ama beerka, iyo sidoo kale soo dhoweynta si wadajir ah la "Allopurinol" qiyaasta medicament hoos tixgelin waa in la hoos u dhigay 1/4 qayb.

"Azathioprine" si taxadar leh u daran uga yeelilahayn kuwa ka bukaan, kuwaas waxaa u Zoster herpes, hablo, deficiency oxidase xanthine, iyo inta lagu jiro radiation therapy ama cytotoxic.

Analogues iyo qiimaha daroogada

Maxaa bedeli kartaa "azathioprine"? Tilmaamaha loogu isticmaalo (qiimaha daawooyinka hoos ku taxan) sheegaysaa in ka fikiray daroogada ayaa facooda yar. The ugu la midka ah ee saamaynta ka mid ah daawooyinka hoos ku qoran:

• "Alpha-fetoprotein."
• "Alfetin".
• "Stemokin".
• "Profetal".
• "Revlimid".

Sida qiimaha, ka dibna soo saarka tani ma aha mid aad u sarreeya. 50 kiniin "azathioprine" celcelis ahaan waa qiyaastii 230 rubles Ruush.

Reviews of medicament

A yar dib u eegista ah ee daroogada "azathioprine" ah macnaheedu waa isku dhafan. Dadka qaarkood daawada sababta oo ah cudur, shalalka, ku qanacsan yihiin oo ay u dayacan tahay wax ku ool ah oo iyaduna ka mid ah waxyeellooyin ba'an. Qaar kale, si kastaba ha ahaatee, bukaanka aan dareemay by natiijo kasta, oo sidaas daraaddeed waxay go'aansadeen in ay siiso doorashada si siyaabo kale.

Waa in la ogaadaa in dhamaan muujinaya ee isticmaalka daroogada "azathioprine" u gudbiyo a cudurada halkii halis ah oo therapy filan noqon karaa oo kaliya xirfadle khibrad leh. Marka tan la eego, in ay dhacdo shaki ah jiritaanka cudur kasta oo ka mid ah liiska kor ku xusan, waa in aad maraan baaritaan dhamaystiran oo caafimaad, in aan la is-Dawada.