"Disulfiram": dib u eegista. "Disulfiram": description, qiimaha

In this article, waxaan go'aansaday in aan kuu sheego in tani ay tahay daroogada sida "Disulfiram". Tilmaamaha loogu isticmaalo, warcelin oo tilmaamaya in lacagta sidoo kale lagu hoos lagu qeexay doonaa. Intaa waxaa dheer, waxaad ku baran doontaa in ay tahay waxa kharashka daawada ku yidhi, waxa la soo saaray nooc kasta oo la mid ah in ay ka kooban, iyo wixii la mid ah. D.

Foomka iyo Halabuurka ee baakada

The medicament "Disulfiram", tilmaamaha loo isticmaalo kaas oo ku lifaaqan sanduuq laga sameeyay baakado, waa suuq ee foomka of xal saliid iyo kiniiniyada maamulka afka iyo rakibida.

foomka koowaad waxaa la soo saaray in toddobada fijaan oo 20 ml, iyo labaad iyo saddexaad - dhalooyinka at 10 iyo 20 halbeeg siday u kala horreeyaan.

Walaxda firfircoon ee medicament waa disulfiram. waxa ka sokow, daroogada kale oo ku jira qaybood oo dheeraad ah (iyada oo ku xiran foomamka sii daayo): chloride sodium, mannitol, istaarijka, ku milmahayn sodium, PEG-6000, MCC, diphosphate calcium, cellulose hydroxypropyl, stearic acid iyo polyoxyl 40.

guryaha pharmacological

Waa maxay noo hor daawada? Waxa ay ku yidhaahdeen oo ku saabsan dib u eegista caafimaadka? "Disulfiram" uu saameyn ku anti-khamriga fahmayaan.

Marka aad hesho qalab this waxaa la ogaadaa in ay saamayn weyn ku-shiid khamriga. Sidaas darteed, metabolites ammaan ah loo sameeyay, taasoo kordhin fiirsashada of walxaha sunta ah sida acetaldehyde. Waxa uu ahaa kuwaas oo go'aamisa waxtarka ah ee daroogada.

Iyada oo maamulka xididka of medicament ah, iyo sidoo kale bukaanka ay afka ku dhow isla markiiba bilaabaan si ay u dareemaan dareen kulayl, dyspepsia ba'an, tachycardia, asthenia xoog iyo xataa hypotension halis. Waxaa intaas dheer, muuqaalka sarkhaan by acetaldehyde gacan ka carar ahayn in khamriga iyo baabi'inta ee ku riixdaan bukaanka khamriga.

beegyada uu pharmacokinetic

Maxaa tixgelin ayaa ku soo koobin ogeed daroogada? Maxaa ku saabsan dib u eegista ay warbixin nuugista? "Disulfiram" arrin degdeg ah oo ku dhowaad si buuxda u nuugo ka mindhicirka.

Marka la isticmaalayo, waxaa jira dheef sare ah qayb firfircoon, inta lagu guda jiro kuwaas oo dhowr metabolites sameeyay. Derivation ee alaabta waa la fuliyay iyada oo sambabada iyo kelyaha.

Tilmaamayaasha

Drug "Disulfiram", qiimaha kaas oo hoos ku qoran, waxaa lagu tilmaamay for:

• daaweynta Khamriyahnnimo chronic;
• ka hortagga labakaclaynta ee daaweynta ee Khamriga chronic.

Qaado dawadan ikhtiyaar loo baahnayn ay. Waa magacaabi dhakhtar.

sababo

Drug "Disulfiram" intravenously iyo hadal laguma talinayo ee cudurada soo socda:

• cudurada neuropsychiatric;
• qalalka,
• diabetes.

Sidoo kale, daroogada this aan la tilmaamay inta ay uurka leedahay, dareenka ah in ay qayb firfircoon oo qayb dheeraad ah, naas-nuujinta.

Sidoo kale waa in Waxaan la soco in si taxadir leh xad-dhaaf ah daroogada this lagu talinayaa in ay qaataan dadka qaba beerka oo yaraada, neefsashada iyo kelyaha.

Drug "Disulfiram": tilmaamaha loo isticmaalo

Isticmaalka nooc kasta oo lacagaha la ogol yahay oo kaliya dhakhtarka amarada. Dhakhtarka ayaa waxaa waajib ku ah in ay sameeyaan baaritaan buuxa ee bukaanka, ka dibna dooran ah daawada qofka iyo qiyaasta isaga for.

Sida laga soo xigtay tilmaamaha, qiyaasta celceliska maalin daroogada ee maamulka afka ku saabsan yahay 125-500 mg.

Sida ee la isku duro iyo rakibida daroogada, ka dibna nidaamyadan waa in loo sameeyaa by farsamo khibrad leh. Xaaladdan oo kale qiyaasta lagula taliyey daroogada waxay ku xiran tahay sifooyinka oo ka mid ah bukaanka iyo darnaanta cudur jira.

waxyeellooyin

waxyeelo daroogada ee su'aasha waxaan wici kartaa? Maxaa ku saabsan odhan dib u eegista ah? "Disulfiram" dhif noqday sabab reactions dhinaca khatar ah. Marka daama waxaa laga yaabaa in qaar ka mid ah leexasho ku jirta marinka dheef shiidka iyo joogitaanka dhadhan macdan iyo horumarinta hepatitis.

Intaa waxaa dheer, xadgudubyada ku dhici kara hawlaha habdhiska. xaaladaha loo baahnayn noocan oo kale ah waxaa ka mid ah polyneuritis ee addimada hoose, xanuunada maskaxda, xusuus lumid, jaahwareer iyo madax xanuun.

Sidoo kale, ma saarayso horumarinta dareen diidmo oo kala duwan xasaasiyad, kuwaasi oo ay ka dhashay saameynta ay khamriga (tus, burburkii, stroke, garaaca wadnaha, barar cerebral iyo Wadnaxanuun myocardial).

Calaamadaha badinta

Diyaarinta "Disulfiram" at qiyaasood sare waxay keeni karaan dhibaatooyin sida burburkii, kooma iyo jawaab dareemayaasha khatar ah.

Si aad u baabi'iyo calaamadahan waa ku qaataan therapy astaamaha isbitaalka, kaas oo waa in ay daruuri tahay waxaa ka mid ah hawlaha naanin.

Lidka medicament

Khubaro ayaa cadeeyay in dhexdhexaadnimada dhamaystiran oo daroogada looma tixgelin karo.

Haddii loo baahdo, wax soo saarka "Disulfiram" ka jidhka bini'aadamka (dose tus, in dareen diidmo oo aad u daran in dhowaan la ansixiyay khamriga) waxaa lagu fuliyaa hab-raacyada qaarkood.

Sida le ah si ay this isticmaalka daroogada ascorbic acid. Waxaa maamula intravenously. element Tani ma ogola khamriga in la beddelaa acetaldehyde, taas oo, dhab ahaantii, waxay keentaa raaxo.

Waxay sidoo kale waxaa laga yaabaa in loo isticmaalo ephedrine iyo H1-blockers.

isdhexgalka daroogada

Ma la aqbali karo si ay u isticmaalaan daroogooyinka kale na hor daawada? Maxaa ku saabsan isdhexgalka daawada dib u eegista leeyahay? "Disulfiram" ee isku darka daawada xinjirowga lidka Kordhiyey tallaabo, iyo sidoo kale kordhisaa halista ah ee dhiig-bax.

daaweynta isku mar la daawooyinka daroogada taas oo metabolized beerka, si weyn u xaqiro karaa inta lagu guda jiro geeddi-socodka.

Isku MAO, murugada tricyclic iyo taagayo phenothiazine leh "Disulfiram" waxaa laga yaabaa in ay gacan ka ah ee reactions dhinaca adag.

Isku darka of taas macnaheedu waa la "buspirone" sababa horumarinta dhibaatooyinkooda. daawo sida "Amitriptyline", inta badan ay wanaajisaa saamaynta "Disulfiram" iyo kicisaa waxyeello sun ay ku habka dareemayaasha jirka.

Viewed medicament awood sii kordhaysa fiirsashada of detox iyo diazepam ee dhiigga, yaraynta xoogga reactions sun ah oo keeni karo wareer.

Iyada oo isku dhafan ee "Disulfiram" with "isoniazid" waxaa laga yaabaa in niyad-jabka iyo wareer, "metronidazole" - wareer iyo psychosis ba'an, a "Omeprazole" - daciif ah miyir, iyo caffeine - jirka hoos u Digo.

"Chlorzoxazone" kordhiyaa-fiirsashada ee daroogada anti-khamriga ee dhiigga, iyo "chlorpromazine" rizqiga hypotension.

Drug "Disulfiram": dib u eegista, qiimaha iyo analogues

Saamaynta la mid ah leeyihiin daawooyin sida "Ekzorran", "Radotera", "Aspen", "Krotenal", "Tetlong", "Refuzal", "Stoptil", "Antietil", "Kontrapot", "Tetradin", "Antietan" "Dizetil", "Alkofobin", "Aversan", "Anticoli", "Antabuse", "Esperal", "Lidevin", "Abstinil".

Waa imisa a "Disulfiram" daroogada? Qiimaha daroogada this kiniinada u dhaxeysa 200-1000 rubles (ku xiran tahay soo saaraha). Iyadoo la tixgelinayo qaabka galaha, iyo sidoo kale xal saliid leh, ay laga iibsan karaa 600-2400 rubles.

dib u eegista Inta badan dejinta la joogo waa wanaagsan. Waxaa xusid mudan in daroogada taas waxaa badanaa loo isticmaalaa si loogu daweeyo qarsoon ee dadka qaba Khamriga. Khubarada ha ku talinaynaa siinta xarunta this aan aqoon bukaan-socodka.

Sida laga soo xigtay war celin ka mid ah kuwa loo isticmaalo daroogada waxaa loo arkaa mid aad wax ku ool ah ku dagaalama rabitaanka inay qaataan qiyaas cusub ee khamriga. Sida caadiga ah, ka dib markii la helo daroogada ee bukaanka baxdo Carar khamriga. Haddii sharaabka khamriga la ansixiyay kadib isticmaalka daroogada, waxa sababa dyspepsia ba'an, barrar, asthenia daran, tachycardia, iyo xataa hypotension halis.