Hemolysis - waxa uu yahay waxan? Hemolysis dhiigga, hemolysis qayb

Burburka xuub unugyada dhiiga gaduudan iyo Digo of hemoglobin galay plasma waxaa lagu magacaabaa hemolysis. Marxaladani waxay dhacdaa ay sabab u tahay tallaabada of haemolysin walax gaar ah (hemolysin). Hargahood oo ka mid ah unugyada dhiigga cas bilaabo inuu ku guuldareystaan sabab u ah sunta ama bakerialnyh soo saaray antibodies. Currently, dhakhaatiirta ayaa loo aqoonsaday dhowr ah oo kala duwan oo ka mid ah geedi socodka this. Waxaa loo kala saaraa ku xiran tahay habka waxbarashada, ka barta at taas oo ag maraaba wuu ka sababa in ay keeni kartaa.

Ogaanshaha hemolysis in - burburinta unugyada dhiigga cas, taas oo hemoglobin la sii daayay ka, dad badan oo aadan fahmin, taas oo ah sababta ay tani u dhici kartaa.

Arrimaha keeni burburinta xuubka erythrocyte ah

Si habka ka qaban, waxaa lagama maarmaan ah si aad u ogaato, taas oo ah sababta burburinta unugyada dhiigga cas bilaabi karaan. Iyadoo ku xiran qaab dhacdo, noocyada soo socda ee hemolysis.

1. Dabiiciga ah. Marxaladani waxay qaadataa meel joogto ah ee jirka, waxa uu bilaabmayaa dhamaadka ee wareegga nolosha caadiga ah ee mid kasta oo ka mid ah unugyada dhiigga cas, oo ku nool oo ku saabsan 100-130 maalmood.

2. Kiimikada. Waxay dhacdaa marka unugyada dhiigga cas loo soo bandhigi doonaa in walxaha in milmi karaan subaga xuub. Kuwaas waxaa ka mid ah kala duwan alkali, alcohols, ethers, chloroform. Tusaale ahaan, waxaa loogu dhawaaqaa hemolysis haddii qofka la sumeeyay dose badan oo acetic acid.

3. Biology. galkeeda erythrocytes bilaabaan inay duleeyaan sabab u ah sunta hemolytic gaadhista, tus, iyadoo ay sabab u qaniinyada cayayaanka ama masaska. Sidoo kale, hemolysis biyoolooji waxa uu dhacaa sabab u shubo dhiigga leheyn.

4. Heerkulka. Marka baraf erythrocyte dhiig kiristaalo barafka loo sameeyay. Ka dib markii ay diirran ay jebiyaan qolof ah.

5. Farsamada. Marka aad salaantid weel dhiig ama qalab bam ay taas kiimikaysan taageeray wareegga, waxyeello erythrocytes.

6. osmotic The. Haddii corpuscles cas dhici on Wednesday, halkaas oo cadaadiska osmotic noqon doono ka hooseeya ku jira dhiigga, waxay qarxaan laga yaabaa. Waa hantidooda loo isticmaalo cudurka of dhiig ama beerka cudurada.

Sababaha hemolysis

In la fahmo waxa iyo markii ay timaado in unugyada dhiigga cas, waa in aad si fiican u fahamto ereyga sida hemolysis. qolof burburinta Tani unugyada dhiigga ku dhici karaa intracellularly amase weelal. Sida caadiga ah, kuwaas oo nooc oo hemolysis sababa cudurada kala duwan. Laakiin sidoo kale xuub erythrocyte wuxuu u baabbi'i karaa iyadoo qofka aan dabiici ahayn ee waxbarashada shaybaarka.

Marka ay timaado in hemolysis intravascular, qolof ah ee corpuscles cas ay dhacdo in ay waxyeello u-socodka ah ee wareegga dhiigga. Tani waxay dhacdaa in cudurada soo socda:

- anemia hemolytic ay ka mid yihiin, shalalka,

- hemoglobinuria nocturnal paroxysmal;

- cudurka paroxysmal agglutinins qabow.

Sidoo kale hemolysis vntutrisosudisty ayaa tilmaamaya laga yaabaa in khubad sunta hemolytic.

burburinta erythrocytes dhacdaa unugyada beerka, beeryarada ama lafta dhuuxa gudahood. Waxaa la arkay at dhibaatooyin caafimaad sida dhaxlo microspherocytosis, dhiig yari, shalalka iyo thalassaemia. Ogaanshaha ku saabsan sababaha taas oo u horseedi burbur xuubka unugyada dhiiga gaduudan, waxa uu noqonayaa mid iska cad in hemolysis - waa khatar. Waana mid ka, kuwaas oo geedi socodka intracellular waxaa inta badan la socda wayneeyo of caajisnimo iyo beerka size.

Calaamadaha hemolysis

Haddii jidhka bini'aadamka bilaabay inuu dumin xad-dhaaf ah unugyada dhiigga cas, ka dibna u aragto kaliya marka koorsada ba'an cudurka. Calaamadaha ugu caansan ee burburinta caasiyoobay of erythrocytes yihiin kuwa: integuments jaalle ama doorsoonka, hoos u cadaadiska, garaaca wadnaha oo degdeg ah. calaamadaha ayaa sidoo kale waxaa ka mid ah ciddiyaha debcaan iyo timo.

Laakiin kuwa badan oo aan samayn xitaa marar badan ka warqabin in ay leeyihiin hemolysis dhiigga. Waa maxay ma ay baran karaan kuwo by shil, baaritaan caafimaad. Laakiin iyadoo koorsada ba'an inta badan lallabo, dawakhaad, daal, daciifnimo iyo xataa qandho.

Hemolysis waxay keeni kartaa dhiig yari, taas oo iyana waa halis ah maxaa yeelay waxa ay keeni kartaa xinjiro dhiig oo sarreeya ama keeni cholelithiasis.

Ma jirtaa sabab argagax?

Waxaa jira kiisas bukaanka waxaa lagu qasbay in ay dib u shaybaar ay sabab u tahay xaqiiqada ah in hemolysis dhacay. Qaar badan ayaa bilaabay in ay eegaan calaamadaha cudurada khatarta ah, lesions sun ah ama si fudud lagu sumoobo. Laakiin inta badan ma jirto sabab walaac, maxaa yeelay waxaa laga yaabaa in xuub erythrocyte wuxuu u baabbi'i sabab u ah arrimo farsamo. Tusaale ahaan, inta badan unugyada dhiigga dhaawac laga yaabaa in geeddi-socodka lagu shubo dhiig in tube imtixaan, haddii irbad aad u khafiif ah ama kalkaalisada si deg deg ah riixo dhiigga. Erythrocytes garaacday derbi tube iyo dilaaca. Sidaas darteed, plasma uu noqdo casaan, iyo waxa ay kala ee centrifuge noqdo wax aan macquul aheyn.

Xaaladaha noocaas ah, waxaannu nidhaahnaa, waxaa jiray hemolysis qayb. Ma aha cudur laakiin sabab u ah dhiig aan habboonayn sampling ay kaydinta, gaadiidka ama taabato. Waayo, falanqayn lagu kalsoonaan karo waxay u baahan tahay qayb ka mid ah oo kala duwan oo dhiigga. bukaanka ay dhacdo in this, ka hor inta uusan ku cel-dayo lagu talinayaa in aad cabto biyo nadiif ah.

hemolysis ba'an

Laakiin haddii sabab u ah daraawiishi ay of unugyada dhiigga cas - ma baadi kalkaaliyayaasha, waxaan ka hadleynaa dhibaato halis ah. Inta badan hemolysis ba'an dhacdaa iyada oo dhiig lagu shubo marka ay jiraan unugyada cas leheyn. Sidaas darteed, waxay keenaysaa in hawshooda u ah ee nidaamka complement ah, xinjirowga iyo difaac humoral.

Waa ay fududahay in la garto, maxaa yeelay, in hemolysis kiiskan - taasi waa dhibaato halis ah, taas oo ku siinaysaa sawir caafimaad oo cad. Haddii bukaanka miyir qabo, uu ku caban doonaa xanuunka xabadka, dhabar xanuun, calool xanuun, caro, dareen qandho, tachycardia. Cadaadiska lahaa in la dhimay. Haddii hemolysis bilaabay inta lagu jiro hawlgalka fuliyay hoos suuxinta guud, calaamado u noqon lahaa dhiig nabro, iyo haddii ay jirto tuubo kaadi - waxaa jiri doona kaadi madow cas ama xataa madow.

cilmi baaris shaybaar

imtixaanada la qaado si loo xaqiijiyo cudurka. Haddii hemolysis bukaanka, Torombositobiiniya markaas natiijada baaritaanka dhiigga waxaa la muujin doonaa, hemoglobinemia, bilirubinemia, yaraynta awoodda oo ka mid ah daawada xinjirowga lidka ku ah iyo fibrinolytic. In kaadida, bukaanka yeelan doonaan heerar sare oo ka mid ah creatine dhici doonaa hemoglobinuria, hyperkalemia, hoos u xaddiga kaadida ilaa ay dhamaystiran maqan.

Marka xaqiijin in unugyada dhiigga laga qaban waa la wada baabbi'iyey, daaweynta ku haboon waa in loo maamulo.

daaweynta

Jooji hemolysis daawo casri ah ciidanka ilaa xad ah. Haddii uu sababay in dhiig lagu shubo, tallaabooyinka daweynta waa in loola jeedo in lagu joojiyo colaadda galiyey of unugyada dhiigga cas. Intaa waxaa dheer, waxaa muhiim ah in la bilaabo shubo ee xal gaar ah oo ka hortagi kara horumarinta hypovolemia, hypoperfusion kelyaha. Sidoo kale plasmapheresis waxaa fuliyay kaas oo ujeedadiisu tahay ee ka kaxayntu ay of wareegaya hemoglobin oo lacag la'aan ah dhiigga. Ujeedada this, in kiisaska intooda badan ku durayaa wakiilka "heparin" intravenously via infusomats. Waxay ka caawisaa si ay ula qabsadaan hemolysis ba'an iyo daroogada "prednisolone". All ballamaha la sameeyey oo ku saleysan xaaladda bukaanka, sidoo kale waxaa muhiim ah in la ogaado sida muddo dheer ka hor ayuu bilaabay hemolysis. Tani waxay ka caawisaa dhakhaatiirta go'aan tabaha daaweyn, maxaa yeelay mararka qaar waxaa lagama maarmaan ah in la qabto kelyaha xaalad deg deg ah. Tusaale ahaan, waxaa lagama maarmaan ah, haddii la ogaaday in bukaan-socodka kelyaha ba'an.

Daawooyinka sida Jidka hemolysis a

At isticmaalka erythrocytes daawooyinka qaarkood ayaa sidoo kale waxaa loo wada baabbi'in karo. Iyada oo la adeegsanayo keenaya hemolysis dhiigga, waxaa ka mid ah kooxo dhowr ah oo daroogada.

1. -Jebin: "Amidopyrine", "Aspirin", "Antipyrin".
2. Diuretics: "Fonurit", "Diakarb".
3. Nitrofurans "furadonin", "Furazolin".
4. Sulfonamides "Sulfalen", "salazosulfapiridina", "salazopiridazina", "Sulfapiridazin".
5. daroogada Hypoglycemic, "Tolbutamide", "Hlorpropamid".
6. daroogada Anti-TB, "Isoniazid", "PAS".
7. daroogada hantibaylihin, "Quinine", "Akrikhin", "Primaquine."

Marka la isticmaalayo wakiilada, kuwaas oo laga dheehan karo hemolysis. Tani ma tilmaamayso wax dhibaato ah, ayuu u muuqataa sida jawaab u daaweynta.