Tallaalka "Menaktra": tilmaamaha, sharaxaada iyo dib u eegis

Tallaalka "Menaktra" - jiil cusub oo daroogada. Little loo yaqaan (qiyaastii 10 sano ka hor), shirkad xad cusub ee abuuray a US Sanofi Pasteur. daroogada ayaa maray taxane ah oo baadhitaano iyo waa wax ka duwan waxyaabaha la midka ah. Waxay leedahay tiro ka mid ah bakteeriyada in ay saamayn ku formation of-beegyada uu difaaca jirka ee u shaqeeyo dhanka ah dhacdo ee meningitis iyo dhiiga sumeynta ay keento meningococcus.

Qaab-dhismeedka

Tallaalka "Menaktra" digtay tiro ka mid ah cudurada, taas oo saameyn ku yeelan muuqaalka kore ee Isirka meningococcus gaar ah. Waa xal wax yar cadda cad maamulka muruqyada dhexdooda.

Mid ka mid ah qiyaas ku saabsan yahay 0.5 ml, waxaa ka mid ah qaybaha firfircoon sida conjugates meningococcal monovalent in ka kooban tahay iskujir ah noocyo ka mid ah serogroups polysaccharide (A, C, Y, W-135) iyo side protein. polysaccharide kasta hal conjugated qiyaas duro diphtheria toxoid siman ilaa 48 mg.

walxaha dheeraad ah ee Halabuurka daroogada waa: phosphate sodium, chloride sodium, laktosmonohydrat sodium dihydrogenphosphate iyo biyaha gaarka ah ee la isku duro.

diyaarinta waxaa la soo baakadeeyey ee dhalooyinka fijaan oo ay ku jiraan dose hal mar ah - 0.5 ml. kartoonka waxay noqon kartaa mid ama shan fijaan, iyo tilmaamaha loo isticmaalo.

Tallaalka waxaa lagu kaydiyaa heerkulka 2-8 ° C. waa in aan la xayiray. Waa in lagu kaydiyaa meel qabow oo ka mid ah carruurtu gaari karin. Haddii daawada sabab qaar ka mid ah ayaa la xayiray, ma aha waajib ah in la isticmaalo dheeraad ah.

Shelf-nolosha ee daroogada waa laba sannadood laga bilaabo taariikhda wax soo saarka ee ku daabacan baakadka.

"Menaktru" saarta saaraha caansan dunida ee tallaalka, "Sanofi Pasteur Inc." ah.

Tallaalka "Menaktra": description ficilka pharmacological

Sida caadiga ah, wakiilka sababaya cudurada meningococcal (tus meningitis) uu noqdo bakteeriyada N. meningitidis. Waxaa loo aqoonsaday tiro ka mid ah serotypes ee kooxdan oo ah bakteeriyada. Isticmaalka tallaalka "Menaktra" wuxuu kobciyaa soo saarka ee antibodies qaas ah si toos ah ka gees ah wakiilka sababaya cudurka meningococcal. Tallaalka wuxuu ka kooban yahay afar Isirka waa A, C, Y iyo W-135. Waxaa oo dhan cilmiga la hawl bactericidal gaar ah.

tijaabo loogu talagalay loo helo natiijo ka dejinta "Menaktry" looma fuliyo, tan iyo doorashada ee antibodies bactericidal serum (SBA) waa heerka tayada shaqo ee tallaalka meningococcal.

tayada difaaca carruurta loola dhaqmo 2 ilaa 10 sano iyo kuwa da'doodu u dhaxayso 11-55 sano. Immunogenicity la goostay in la eego ka shaqeynayaan ee antibody ah, kaas oo la ogaado by dayo bactericidal serum. Kooxda Shaqsiyaadka da'da 2-10 sano tixgeliyo jawaabta difaaca in samaynta hal tallaalka, iyo 28 maalmood ka dib. korodhka-baadh oo joomateri dhexe loo aqoonsaday (GMTs) ee antibodies bactericidal. Dhammaan noocyada serogroups in 86-100% ka mid ah xaaladaha ugu tilmaame hore titers ah lagu arki karin ayaa laga soo minguuriyay seroconversion, lagu gartaa sida chetrehkratnoe iyo kaca ee titers antibody at 28 maalmood tallaalka ka dib.

awoodda go'an "Menaktry" saamayn ku xasuusta difaaca tallaalka ka dib aasaasiga ah ee carruurta iyo dadka waaweyn.

Natiijada baaritaanka ee dadka 11-18 sano ayaa muujiyey in jawaab difaaca jirka si formation hal mar oo tallaalka ah. Muujiyeyaasha SBA GMTs 28 maalmood tallaalka ka dib waxay ahaayeen wax badan ka badan asalka ah. In 98-100% ka mid ah dhallinyarada, iyadoo aan la hubin ee heerka unugyada bilowga maalinta 28 ayaa lagu muujiyay koror cherehkratnoe in titre SBA dhammaan nooc oo tallaalka Isirka B. xaqiiqooyinka waxay muujinayaan immunogenicity sare ee daroogada da 'cayiman.

In dadka waaweyn ee titers antibody xukunnada in 93-100% ka mid ah xaaladaha muujiyey koror afar laab ah baadh oo SBA ee dhammaan noocyada kale ee pathogene serogroups in Halabuurka tallaalka. In tijaabooyinka oo dhan, jawaabta difaaca ahaa isku loo eegin jinsi, da 'iyo jinsi.

Ma jiraan wax tilmaamayaasha ku kinetics jawaabta bilowga ah in formation of tallaalka, laakiin jawaabta difaaca 7-10 maalmood ka dib tallaalka ka dib waxaa laga soo qoray.

Duration ilaalinta difaaca ka dib tallaalka formation hore cadeeyay in tijaabo oo waa loo siman yahay ilaa saddex sano ka dib markii maamulka hal.

Tilmaamayaasha

Tallaalka "Menaktra" waxaa loogu talagalay in looga hortago cudurka meningococcal. Xaaladan doonana saameeyaa bakteeriyada N. meningitidis la cayn ah sida of serogroups sida A, C, Y iyo W-135 ee dadka da'da kala duwan.

Sababo in Soon ee tallaalka

"Menaktra" (tallaalka) waa in aan la isticmaali ee case of-diid ama Walxaha firfircooni dheeraad ah ee ay ka kooban. cudurada Ban waa faafa iyo non-faafa dabiiciga ah, iyo sidoo kale inta lagu guda jiro exacerbations cudurada raaga.

Qiyaasta iyo habka tallaalka

Diyaarinta "Menaktra" (tallaalka) maamula intramuscularly taliya guide, la doorbidayo ee degaanka oo ka mid ah muruqyada deltoid garabka. Caruurta ilaa sanadka daroogada la maamulo muruqa bowdada aagga, tan iyo this category ka mid ah muruqyada garabka bukaan yihiin dib dhacsan. Ekaataa la sameeyaa hal mar oo keliya at qiyaasta ah 0.5 ml.

Ka hor inta ah ee tallaalka u baahan tahay in ay u hoggaansamaan tallaabooyinka ammaanka qaarkood, kuwaas oo loogu talagalay ka hortaga cawaaqib aan la rabin. Waxaa lafaguraa gobolka ee caafimaadka ee qofka, aad u ogaato joogitaanka sababo.

Tallaalka waa uun gurmadka ah oo ay gacanta ku hayaan. qolka A daaweynta tallaalka sida waa in lagu qalabeeyaa daroogada antishock si loogu soo daweeyo.

Mararka qaar, ka dib hordhaca ah ee la isku duro ayaa lagu arkay suuxid. shaqaalaha caafimaadka, tallaalka, waa in uu diyaar u yahay xaaladda noocan ah iyo in hab wakhti si looga hortago in dhaawac la xiriira dhicid, iyo sidoo kale in ay bixiso daryeel caafimaad oo lagama maarmaan noqon.

Waxaa jira dokumentiyo caafimaad badan in loo ogaado sida tallaalka waa in la isticmaalaa "Menaktra". jadwalka tallaalka waa sida soo socota:

• Ilmaha da'doodu tahay 9-23 bilood, tallaalka la riday laba marxaladood. Ka dib markii tallaalka ugu horeysay ka dhigi nasasho muddo saddex bilood ah, ka dibna samayn labaad.
• Carruurta laba sannadood, dhallinyarada iyo dadka waaweyn ee daroogada la intramuscularly maamulo, iyo hal mar oo keliya.

daroogada wuxuu bixiyaa ilaalinta cudurka meningococcal, taas oo u muuqato toban maalmood laga bilaabo taariikhda tallaalka ka dib. qiyaasta sii xoojinta kiiskan lama siineyo.

Dhexgalka daroogooyinka kale

Daawo "Menaktra" (tallaalka live) lagu maamulo waxaa laga yaabaa in lagu daro tallaalka polysaccharide ah, dhacdo digniin tiifowga. Marka lagu daro tallaalka adsorbed teetanaha iyo gawracatada. Wadaagista tallaalka kor ku xusan waxaa laga yaabaa in ee da 'kooxeedyada 11-17 iyo 18-55 sano ah.

Waxaad gelin karaan labada tallaal "Menaktra" iyo tallaalka BCG.

Haddii laba tallaal la fuliyaa waqti isku mid ah, waa in ay in la sameeyo qaybaha kala duwan ee jidhka. Waayo, cirbad kasta isticmaasho sirinj oo kala duwan.

Uurka iyo nuujinta

Sidaas darteed of tijaabo ballaaran, waxa la ogaaday in aanay jirin saamayn xun ku uurka iyo tallaalka ilmaha caloosha ku "Menaktra". Description of daroogada, inkasta oo waxaa lagu talinayaa in la isticmaalo in muddo this, haddii lacagta ku iman kara in hooyada weyn naefigooda, khatarta u tahay horumarka ilmaha caloosha ku. Tusaale ahaan, isticmaalkeeda waa la ogolaan karo haddii cudurka meningococcal waa weyn, oo leh cudurka faafaya ama booqasho uu ku meel-gud.

Ma bartay awoodda ka mid ah maaddooyinka firfircoon ee tallaalka galaa haweenka quudinta caanaha naaska. In tijaabooyin hore ee antibodies tallaalada sida ay u polysaccharides helay jiir oo dhallinyaro ah, kuwaas oo weli quudinta hooyada. Dhab ahaantii waxa uu saameyn ah kuma laha horumarinta farcankaaga. waxbarashada la midka ah ee aadanaha oo aan la sameeyay.

Ka hor inta aadan tallaalo qof dumar ah inta lagu jiro nuujinta, waa in aad si taxadar leh u fiirsado halista iyo faa'iidada ka iman kara tallaalka.

Tallaalka "Menaktra": waxyeellooyin

Ka dib markii tallaalka la daroogada this in bukaan badan oo ka walwalsan ah oo ku saabsan falcelinta xun kala duwan. Symptomatology waa kala duwan taas oo ku xidhan aqoonsiga da.

Sidaas darteed, shakhsiyaad ka laba ilaa toban sano lagu calaamadeeyo danqasho, induration, barar iyo casaan ah zone muday. Caruurta tallaalka ka dib ayaa Cadha daraadeed, waxaa jiray hurdo. Xaaladaha qaarkood, waxaa anorexia, shuban, matag iyo qandho. kids naxaysaan cun-cun, iyo urtikaria. Waxaa jiray daliilka qaab arthralgia.

Caruurta qaangaarka ahi 11-18 sano iyo dadka waaweyn ee ay da'doodu u dhaxayso 18-55 sano, waxaa jiray xanuunka iyo induration ee hordhaca ah ee tallaalka. Waxaan ku xanuunsado oo ka madax xanuun, shuban, matag. Kacay daal. Hoos u dhac rabitaanka cuntada. finan, arthralgia la arkay. Waxaa jiray qandho, qidmeyntiibulshada ee guud, qandho.

Waxaa jiray dareen-celin kala duwan diidmo. Guillain-Barre syndrome ayaa lagu arkay, khasaaraha qayb ka mid ah xasuusta, qalal, curyaannimo ee dareemaha wajiga, paresthesia, myelitis transverse, dawakhaad, encephalomyelitis faafiyay foomka ba'an, myalgia.

Tallaalka "Menaktra" cudurka Meningococcal keeni kartaa noocyo kala duwan oo cudurro, laakiin waxay yihiin fudud iyo baaba'aan hal toddobaad gudahiisa kadib tallaalka.

ganaaxyada

"Menaktra" tallaalka meningitis waxa lagula talinayaa dadka halis kordhaysa oo ka qaadida cudurka meningococcal. Kuwani waa dadka kuwaas oo xiriir toos ah la bukaanada qaba meningococcus. Waa in aan dadka tallaalka la deficiency properdin ah, oo la dhamaystiro qaybaha. Tallaalka waa muwaadiniinta muhiim ah la asplenia. Waxa kale oo ay ka dhigi kartaa dadka u safraya meelaha hyperendemic, iyo shaqaalaha shaybaarka si joogto ah qabashada waxbarashada kala duwan oo ku saabsan saamaynta bakteeriyada N. meningitidis. Dhakhaatiirta ku talinaynaa tallaalkan la siiyo ardayda ku nool kuleejo ah, iyo dhallinyarada gurmadka.

Daawada waa in aan si intravenously maamula, hurin subcutant. waxa ka dhalan kara xogta sida in la rakibo waa dawo wax.

Marna ha isku xiro tallaalkan hal saliinge daawooyin kale.

Ma bartay saamaynta tallaalka on bukaanka qaba Torombositobiiniya ama dadka ka cabanaya xanuunada dhiig. Waxaa jira halis ah oo dhiig-bax markii intramuscularly maamulo. In the case of saarka tallaalada dadka sida waa in ay miisaamaan khatarta iyo faa'iidada.

hannaankii A la mid ah ayaa lagu arkay cudurka Guillain-Barré syndrome. Waxaa jiray kiis oo faafidda cudurka ka dib markii maamulka tallaalka. Sidaa darteed, wejiga tallaalka, ka cabanaya Guillain-Barre syndrome ka hor, waxaa lagama maarmaan ah in si taxadar leh loo qiimeeyo dhammaan khataraha caqligalka ah.

daroogada ma hortago meningitis huriyay kale micro-organisms iyo bakteeriyada, iyo sidoo kale cudurada ay keento cudurka meningococcal Isirka B

In dadka qaba difaaca jirkooda uu daciif iyo kuwa daaweynta jirka waa inta badan jawaabta la dhimay difaaca ah ee talaalada "Menaktra". A jawaab difaaca difaaca loo ahbaa karaa ma bukaan oo dhan si siman yihiin 100%.

Ka hor inta gurmadka soo socda ee tallaalka ama dhakhtarka waa in ay wargeliyaan dadka buka oo ku saabsan khatarta ama faa'iidada talaalka maamulka, iyo sidoo kale dhibaatooyinka suurogal.

Reviews tallaalka

Waxaa qoreysa khayroon daahirnimo kiimikada sare, oo deggan iyo go'aamiso ilaalinta difaaca dheer iyo multivalency "Menaktra" (tallaalka). Comments saabsan kulantay this inta badan wanaagsan.

Hooyooyin badan ku riday tallaalka in ay carruurtooda da'da hore, iyo ka dib. Waxay sheegeen in ay si fiican u dulqaadan iyo dhif keena dhibaato. kids Qaar ka mid ah maalmaha ugu horreeya ee tallaalka ka dib ayaa lagu arkay korodhka ee heerkulka jidhka ka 37,2 ilaa 40 ° C. Ka welwelsan caro xad-dhaaf ah, hoos u xumo. Dhakhaatiirta jawaab u hooyooyinkood farax oo ku saabsan waxa ay ku yidhaahdeen in ay tahay iska caadi ah, iyo in jawaabta difaaca tallaalka sidaa darteed waa in la sameeyay. Nasiib wanaag, munaasabadaha sida ahaayeen muddo gaaban, iyo hooyadeed joojiyay walaac ugu dhakhsaha badan, waayo gobolka ee ilmahooda.

Sidoo kale, dhakhaatiirta waxaa lagula talinayaa in la siiyo tallaalka, "Fenistil" ama daroogooyinka kale ka dhanka ah xasaasiyad. Dadka waaweyn inta badan si fiican u dulqaadan, oo aan wax cawaaqib xun.

Dadka qaar ma fahmin, sababta dhigi tallaalka sida aan dhaqtar kuu qorin ee. Ogow in dadka ku nool Russia, iyadu waa lagama yaabo in uu noqdo mid waxtar leh, tan iyo inta badan dadka buka la meningitis noqday, helay cudurkan ma waxaa sabab u ah serogroups A ee meningococcal, C, Y, W-135, iyo sabab u tahay cudurada ku wareejiyo. Waxay ku doodayaan in nooca ugu daran ee meningitis waa meningococcal isirada B, iyo waxa ka taariikhda jiro tallaal.

In kasta oo muranku ka, dad badan ku riday tallaalka "Menakra" naftooda iyo carruurtooda. cawaaqib xun ka waa mid aad u dhif ah, laakiin waxay ka difaacdaa qofka cudurada meningococcal nolosha oo dhan. Dhab ahaantii Tani waxaa xaqiijiyay badbaadiyey kun oo qof adduunka oo dhan.