Bisfosphonates (diyaarinta): sharaxaad, tilmaamo, marqaatiyaal. Bisfosphonates ee daaweynta osteoporosis

Marka lafaha aadanaha noqdaan kuwo jilcan oo debcaan, oo ay dhacdo in qaar ka mid ah cudurada lafta, tayada nolosha waxaa si weyn u dhimay. jab soo noqnoqda, xanuun kala goysyada, dhabarta iyo addimada ay bilaabaan in ay raaci nin meel kasta, taas oo ah sababta aad gebi ahaan la joojiyo karaa dareen farxad u ah nolosha iyo dhumbadaan quusan.

Laakiinse farxad wuu idinla weheliyaa dunida maanta jira daawooyin gaar ah oo wax ku ool ah la xoojiyo karaa unugyada lafta. Waa iyaga oo ku saabsan iyo ka wada xaajoon doona in our article. Yeedhay daroogo "bisphosphonates" - daroogada in dib u eegis oo rajo ka daawo loo helo dad badan oo quus ku siin kara. I rumaysta, wax badan oo noocan oo kale ah! Waxaan kuu sheegi doonaa ah oo ku saabsan taariikhda lacagtaas, waxa ay si fiican yihiin, waxa sal u ah faa'iidooyinka caafimaad ay, daabici doonaa magacyada bisphosphonates yihiin kuwa ugu caansan oo wax ku ool ah.

article wuxuu noqon doonaa waxtar u leh qof kasta. Ka dib oo dhan, xataa haddii maanta wax walba waa si, ka dibna, nasiib daro, taasi micnaheedu ma aha adiga iyo kuwa aad jeceshahay caafimaadka, waxa ay weligoodba sii jirayaan. Years by tag, dheeriga ah ee ay cudurka ayaa noqonaya mid aad iyo aad u badan. Sidaas waxa ku saabsan daawooyinka casriga ah ma noqon doonto mid aan micno ku fadhiyin. Laakiin ku filan ee dhowaan yimid! Aynu u guurto on baadhitaan dheeraad ah oo dhab ah oo theme of this article.

Bisphosphonates - daawooyinka caafimaadka lafaha

Kooxda Selective daroogada dardaro in ay leeyihiin awood u leh inay xannibi dhaqdhaqaaqa jirka ee osteoclasts (unugyada in baabbi'in unugyada lafta) iyo soo celiyo qaab-dhismeedka lafta waxaa loo yaqaan bisphosphonates.

Loo isticmaalo daroogada, kuwaas oo haatan ku jira kaalinta koowaad ee daryeelka bukaannada qaba osteoporosis iyo cudurrada kale ee keeni lafo jilic. Hantida ugu qiimaha badan ee bisphosphonates sidoo kale waa xaqiiqda ah in ay la isticmaali karaa cudurada oncological lagu gartaa formation of burooyinka ku dhaca lafta. Xaaladahan, daroogada, kuwaas oo sheegayaa our article, ma siin metastases faafin iyo in la yareeyo xanuunka bukaanadaan.

hab ay of tallaabo of bisphosphonates ee daaweynta ee osteoporosis

In cutubkii hore, waxaad ogaatay in bisphosphonates - daroogada in kor loogu lafo caafimaad. Waxaa la joogaa waqtigii la hadal badan oo ku saabsan hab ay of ay tallaabo. unugyada jidhkeena ayaa awood u leeyihiin cajiib ah waqti ka waqti la simay iyo dayactiray. unugyada lafta - waa laga reebo lahayn. Dheelli dhismayaasha ay ku hayo, oo gacanta ku hal, unugyada osteoblast in masuul ka ah dhismaha unugyada cusub yihiin, kale - osteoclasts in masuul ka ah ay baabba 'tahay. BF awood u leeyihiin in ay hoos u dhigi shuqulka osteoclasts iyo xataa ordi ay hab isku burburin lahaayeen. At hantida this cajiib ah iyo daaweynta bisphosphonate ku salaysan ee osteoporosis.

Waa inaan sheegaa in saynisyahano iyo hadda aan si buuxda u fahamsan yahay hab ku furid ee lumista lafta isticmaalaya bisphosphonates. Waxaa la og yahay in walxahan waxay awoodaan in ay ku xidhaan in ay qaybaha lafaha hydroxyapatite, ku dheehan yahay wax ka badali karo ay isqaloocinta iyo waqti isku mid ah loo yareeyo fiirsashada dhiigga hydroxyproline iyo phosphatases ah.

Mararka qaarkood diyaarinta BF lagu maamulo waxaa laga yaabaa in daaweyn jiray xitaa of cudurada sida sheelo ama protrusion ee cajalladaha intervertebral, sida wakiilada xanuunka. Iyo macluumaad dheeraad ah oo yar: bisphosphonates for osteoporosis loo isticmaalay muddo dheer, laakiin kansarka, waxay dhowaan la isticmaalo. Iyada oo la adeegsanayo waxbarashada waxaa la ogaaday in galaya jidhka, halkaas oo firfircoon ee la heli karo ee geedi socodka neoplastic, bisphosphonates ma siin burada unugyada Akhristoow la furta lafta, Kuna joogsada formation of metastases. Faahfaahin dheeraad ah oo arrintan ku saabsan waxaa ka wada xaajoon doonaa cutubka gaar ah.

A yar oo taariikh

Waxaa soo baxday in bisphosphonates laga helay by saynisyahano muddo dheer, xataa qarnigii XIX ah. Waayo, markii ugu horeysay ee ereygu wuxuu ahaa ee BF hore fuliyay Germany. Waxa la yaab leh in walxahan waxay asal ahaan loo isticmaalo oo kaliya in qaybaha warshadaha kala duwan (wax soo saarka ee Bacriminta, soo saaridda dhar, turxaan batroolka iyo sida D. ah.) Oo la xidhiidhin daawo ah ma ay lahayn.

Ujeedooyinka caafimaadka - oo lagu daweeyo lafta - bisphosphonates waxay bilaabeen inay in la isticmaalo oo kaliya bartamihii qarnigii labaatanaad, markii la helay hantidooda la yaab leh in ay saamayn ku marayo sida kalshum iyo decalcification. Bisphosphonates for osteoporosis isticmaalay tan iyo adduunka oo dhan ay yihiin kuwo aad u firfircoon.

dirka bisphosphonates

Maanta, Farmashiiste horumariyo qarnigan biosfosfonatov saddexaad. Laakiin taasi macnaheedu ma aha in dhakhaatiirta ayaa gabi ahaanba ka baxay isticmaalka daroogada ee jiilka kowaad iyo labaad, kuwaas oo ahaa ka badan sidii hore abuurtay. Yaanay noqon! Maanta waxaa jira daawooyin badan oo ku salaysan yihiin bisphosphonates. All kala duwan this ee daawooyinka waxaa loo qaybiyaa laba kooxood: bezazotovye daawooyinka iyo nitrogen. Waxay saamayn on unugyada osteoclast uu leeyahay farsamo ka duwan. Hoos waxaan eegi doonaa labada kooxoodba si faahfaahsan.

bisphosphonates nitrogen-ka kooban

Kooxdaan daroogada waa bisphosphonates, oo ay ku jiraan kuwa soo socda sinji:

• Ibandronatovaya acid. E maalka ayaa dhawaan ku dhexsameeysmo jirka, sidaa darteed waa daroogada qarnigii saddexaad. Waxaa inta badan si guul ah loo isticmaalo ee daaweynta iyo ka hortaga osteoporosis in dumarka galay waqti adag dayska. Ragga qaadashada daroogada this laguma talinayo. Ibandronatovuyu acid waxaa sidoo kale loo isticmaalaa in la kordhiyo bahal ah ee calcium dhiigga (hypercalcemia).
• Zolendronovaya acid. Sidoo kale wuxuu la xiriiraa qarnigooda saddexaad u bisphosphonate ah. Awoodaan in ay eegista dhaqmaan on nudaha lafaha. Iyada oo ay taasi waa wax ku ool ah loo isticmaalo daweynta ee osteoporosis. The acid tallaabo zolendronovoy ee doorashada qaab-dhismeedka lafta ku salaysan yahay in ay xidhiidh buuna sare si ay daaqaddii osseous bixiya Iscelin fiican osteoclasts. hanti kale oo muhiim ah sida daroogada - a saamayn anti-buro fahmayaan. On ku salaysan bisphosphonates caan heli acid zolendronovoy "Zometa", "Zolendronat".
• sodium Alendronate - hab jiilka labaad ee bisphosphonates. Waa proofreader gaar ah unugyada lafta aan ahayn hormoon dheefshiidka la xirrira qaabka saxda ah ee lafta. Waxaa lagu muujiyay si ay u isticmaalaan ragga osteoporosis iyo dumarka labadaba.
• sodium Ibandronate ( "Bonviva" "Bondronat" "Boniva" - bisphosphonates diyaar garowga ay ku salaysan) - daroogada qarnigooda saddexaad. Hakiyo dhaqdhaqaaqa osteoclast aan saameeya tirada iyaga ka mid ah. Waxa aanu si xun u saameyn kuma formation of unugyada lafta, sidaas wiiqday ay u halligmaan. caawimo wanaagsan in haweenka postmenopausal sida wakiilka ka hortag ah oo jab lafta.

Diyaargaraw aan nitrogen ku jira

Oo haatan waxaan diirada saari doontaa waxa ay tahay a bisphosphonates nitrogen-free. Daroogooyinka, oo magacyada aad hadda akhriyey, waxaa iska leh jiilka koowaad ee bisphosphonates:

• "Clodronate." Waxay ka hortagtaa osteolysis iyo hypercalcemia horumarka labadaba. Waxa ay qaab xiriir adag la lafta hydroxyapatite badala daaqaddii crystal iyo si firfircoon counteracts kala ah calcium iyo phosphate taagoo. Metastases in lafaha caqabad ay horumarka iyo blocks abuurka ah ee hay'adaha cusub.
• "Sodium Etidronate". Abaabul dib u soo celinta ee lumista lafta in haweenka la ogaanshaha "osteoporosis". Waxa kale oo loo isticmaali karaa cudurka Paget ee, hypercalcemia iyo wixii la mid. D.
• "Tiludronate Sodium". Mineralizes iyo xoojisaa nudaha lafaha, aruursaday xarunta iyo calcium dhexdeeda kelli phosphate, hakiyo burburinta lafaha. Qoray in bukaanka qaba cudurka of "deforming osteodystrophy" ama "cudurka Paget ee" waxaa laga yaabaa in loo magacaabo halkii hormoonnada.

Bisphosphonates - daroogada, liiska oo aan daabacnay - iibin kaliya on qoro, waa in ay walxaha awood ... iyaga Isticmaal ay digtoonaan noqon kartaa khatar u ah caafimaadkaaga! Xusuusnow BF in - ma aha vitamins aan dhib lahayn ama supplements la calcium. Daawooyinkan waxaa si firfircoon fara geedi socodka ka dhacda jidhka, iyo haddii si khaldan codsatay kaa caawin karaan halkii ay waxyeello.

sharciyada gelitaanka

daroogada bisphosphonates arrin si dhib leh u nuugo mareenka caloosha iyo mindhicirka, ay nuugista adag. Sidaa darteed, waxaa si xoog leh waa edbinta qoray cabo daroogada, kuwaas oo keliya calool madhan, oo ku saabsan 30 daqiiqo cuntada ka hor - sida caadiga ah waxay ka caawisaa nuugista of walxaha daroogada firfircoon. Bukaan-socodka u baahan tahay in la ogaado in kooxdan oo ah daroogada wuxuu keeni karaa caabuq iyo nabaad in qaybaha kala duwan ee mareenka caloosha iyo mindhicirka. Si looga fogaado dhibaatooyin kale, ka dib markii la helo loo baahan yahay in ay isku dayaan kiniin inta lagu jiro saacadaha aan tago, oo jooga meel qumman. qiyaasta ayaa la doortay uu dhakhtarka xaadirka ah.

Sida caadiga ah, ballanta dhakhtarka bisphosphonates qoro bukaanka weli oo qofku cuno ee qaadasho badan oo calcium. Sidaas daraaddeed, soo dhaweynta isku mar labada saaray. Diyaargaraw ka kooban calcium, waxaa laga yaabaa in dib markii bisphosphonate kaliya laba saacadood ka dib, oo aan ka hor. talo muhiim kale: CF u leeyihiin in ay cabto shaah lahayn, caano, juus ama kafeega, iyo biyo cad (wax badan oo ka mid ah).

Isticmaalka bisphosphonates cudurada neoplastic

hadal badan oo ku saabsan daaweynta bisphosphonate cudurada ku lug leh koritaanka burooyinka ee dabiiciga ah oo kala duwan. dhacdo ee metastasis in unugyada lafuhu waa dhinac la isdhexgalka xidhaya ee u dhexeeya unugyada burada iyo hawlaha dheefshiidka unugyada lafuhu. Taa baddalkeeda, horumarinta firfircoon ee metastases waxaa ku weheliyay Amda unugyada burada dhismayaasha lafaha, iyo sidoo kale duulaankii, badashada iyo neoangiogenesis. waxbarashada preclinical fara badan ayaa loo ogol yahay in ay sameeyaan saynisyahano male ah in uu BF joogsada kasta oo ka mid ah heerarka kala duwan ee pathogenesis.

In koorsada of dhawr barnaamij cilmi baaris aan qiimeeyo saamaynta bisphosphonate "Clodronate" on horumarinta metastases lafta in dumar kasta laga helay kansarka naasaha. Natiijooyinka fiican ayaa la helay: diyaarinta caawiyey in la yareeyo dhacdooyinka metastases iyo koritaanka unugyada lafuhu ka cusub ee bukaanka. Currently, cilmi jihada this waxaa si firfircoon uga sii. Bisphosphonates markii metastases lafta run ahaantii ay awoodaan in ay ku caawiyaan.

burooyinka halista ah waxaa inta badan la socda (soo daynta calcium ka jabto) hypercalcemia. Marka nabar xadka- ah calcium lafaha khasaaro degdeg dhacaa sabab u tahay burburinta by osteoclasts. Intaa waxaa dheer, hypercalcemia in kansarka awood u dhacaan sabab u tahay gaadhista peptide buro. Dheeraad ah, waxaa jira hawshooda u ah osteoclasts, taasoo keentay in hypercalcemia. Tani waxa adag iyo sidoo kale degdegsiimada by yaraynta shaqo kelyaha.

Nidaamkan waa dhacdo la carcinogenic sida carcinoma squamous cell, myeloma, kansarka naasaha, kansarka unugyada kelyaha iyo lymphomas qaar ka mid ah. Hypercalcemia, xanaajiyeen by kansarka, dawooyinka ugu waxtarka badan yihiin bisphosphonates for galiyey xididka. Well aasaasay kiisaskan, daawooyin sida, bisphosphonates, sida "acid Zolendronovaya" iyo "Pamidronate".

Kormeerka ayaa muujinaya in mar hore dhawr maalmood ka dib markii bilow maamulka bukaanka intravenously daroogada data-fiirsashada calcium, dhiiggu waa caadi, iyo saamaynta ay ku dhammaataa muddo dheer waqti (hal ilaa laba toddobaad).

Liiska cudurrada, taas oo bisphosphonates waxaa si guul ah loo isticmaali

• Osteoporosis.
• Myeloma.
• Xadgudubyada of formation lafaha.
• Paget ee cudurka (deforming osteodystrophy).
• hyperparathyroidism Hoose.
• Burooyinka iyo metastases ee lafta, gaar ahaan weheliso hypercalcemia.

waxyeellooyin

Nasiib darro, daaweynta bisphosphonate firfircoon ma noqon karaan buuga. Gaar ahaan marka ay timaado maamulka xididka ah daawooyinkan. Waxay keeni kartaa dhibaatooyinka negative soo socda:

• Marka intravenously maamula, - hypocalcemia.
• si xun u saameyn karaa kelyaha, keeni sarkhaan.
• Mararka qaarkood biosfosfonatov abahaaga dhaweynta dhirfinaya horumarinta osteonecrosis daanka.
• Qayb-qaato horumarinta ee boogaha ee hunguriga iyo caloosha.
• waxay keeni kartaa calool engeg ama shuban, marmar dhif ah - adag tahay in wax liqidda.
• qidmeyntiibulshada Guud, daciifnimo, lallabo.
• Murqo xanuun.
• Dhibaatooyinka Vision.
• Dildilaaca on jidhka.

Haa, oo dhan dhibaatooyin waxay keeni karaan bisphosphonates. Daroogooyinka, magacyada kuwaas oo aad la kulanto in this article, ma aad naftayda si madax banaan u magacaabi karaa si aan u kasayn waxyeello jirka hagaajin ah. Waxaan si ula kac ah u celi dhowr jeer qoraalka! Siidi oo ay dib u eegista, taas oo la akhrisan kartaa in forums kala duwan, qof ayaa si firfircoon uga wadaaga macluumaadka kasta oo kale oo ku saabsan BF kala duwan oo diyaar iyaga ku talinaynaa in ay dadka kale. Tani waa xoogaa xumo. Qaado kuwan daroogada awood loo baahan yahay oo kaliya uu ka talo-dhakhtarka dhigata oo had iyo jeer hoos kormeer.

Bisphosphonates - eegista dhakhtarrada iyo bukaanka

Ma ogtahay in sanad kasta, on October 20, dalalka oo dhan Maalinta Adduunka ee dagaalka ka dhanka ah osteoporosis? Cudurku wuxuu sannadihii la soo dhaafay, isuna si dhab ah Joogaba faafa. Inkastoo khubarada qaar ka mid ah waxay aaminsan yihiin in degdeg ah dhibaatada of osteoporosis waxaa xoogaa buunbuuniyeen, maxaa yeelay, cudurku ma aha oo iniinahoodu ku dhex dhinto. Si kastaba ha ahaatee, boqolkiiba ee dadka waayeelka ah kuwaas oo dhiman ka dib markii jab sinta ah, taas oo inta badan waxay dhacdaa marka waxaa la degdegsiimada lafo beesho waa mid aad u ballaaran. Sidaas daraaddeed, tiro badan oo dad ah ayaa rajo gaar ahaan on bisphosphonates. Reviews bukaanka helay daawooyinkan maxaa yeelay, rajadii reer kabashada, xaladii la mahadceliyay dhakhaatiirta iyo dawooyinkooda casriga ah, taas oo u awoodin inuu iyaga ku siiyaan caawimaad waqtiga.

Dr. med. , Oo ah borofisar iyo madax ka ah xarunta cilmiga ah-Clinical of osteoporosis Svetlana Rodionova ayaa aaminsan in xaaladda la osteoporosis daran ee Russia. Dhakhtar si fiican u yaqaan ayaa sheegay in maalmaha cimrigayaga, marka xoogga inta badan dadka waa haleysan yahay (la'aanta calcium), heli qaybinta mass of caadooyinka xun sida sida sigaarka, isticmaalka daroogada iyo khamriga, iyo dhaqdhaqaaqa jirka si degdeg ah u dhowaanin eber, dad badan oo dhallinyaro ah, inta badan haweenka lagu xukumay sano osteoporosis dheeraad ah baaluq. Sidaas baahida loo qabo daawooyin wax ku ool ah oo wanaagsan si ay uga caawiyaan daweeyo cudurka tani waa mid aad u sarreeya.

Sida dhakhtarkaaga joogtada ah ee bisphosphonates ballan, professor ah ee ra'yi ah in aan had iyo jeer xaq. Bisphosphonates - qaab-qaadidda daroogada, laakiin ka hor inta dejinaya warqad gaar ah, dhakhtarka waa in ay hubiso in ay qaataan galay account arrimood sida shiid ee lafaha iyo calcium homeostasis. Marka therapy bisphosphonate ka taxadar la'aan iyo caasiyoobay keeni karaa dhibaatooyin daran, wadne, osteonecrosis daanka, jab subtrochanteric ee lafta bawdada ah.

Iyada oo ku saleysan aragtida ah dhakhtar la ixtiraamo, bisphosphonates ma aha talogelin universal, isticmaalkooda waa in loo soo dhawaaday si taxadir leh. Dhinaca kale, barnaamijka "Health" waxaa laga baahiyey telefishanka, halkaas oo Elena Malysheva isagoo dhoolacadeynaya macaan dhaadhiciyo dhagaystayaasha in uusan jirin wax badan ka sahlan in la daweeyey osteoporosis, a-qarnigooda saddexaad u bisphosphonate. Ha aad u hallayn infomercial. Dadka qaar qaata BF gabi ahaanba waa la ahaan uu u. Tusaale ahaan, dadka qaba cudurada kelyaha ee daran.

Haddaba dib u eegis ku saabsan sida loo shaqeyn bisphosphonates markii metastases lafaha. opinion Medical waa cad yahay: daawooyinkan runtii waa ay awoodaan in ay joojiyaan in koritaanka lafaha unugyada malignant, kaas oo, Dabcan, waxay ka caawisaa dadka bukaanka ah mid ka mid ah cudurada ugu daran, taas oo kaliya ka jirta dunida ka adkaan ah.

gunaanad

Hadda waxaad ogaan waxa ay tahay - bisphosphonates. Tilmaamaha si ay u isticmaalaan halkan ka soo baxay, sidoo kale liiska daawooyinka inoo siiyey ma aha sida talo iyo waa hanuun keliya - fadlan lacag bixisid si aad this fiiro gaar ah! Haddii dhibaatooyin halis ah uma baahna in ay is-Dawada caafimaadka, ugu fiican - si deg deg ah u aragto takhtar, sidaasi darteed waxa uu ku soo watay inaad diyaar caafimaad. Waxaan kuu rajeyneynaa caafimaad xooggan iyo farxad!