Daawada "Atokor": waxbarida buugan, analoogga iyo dib u eegis

heerka kolestaroolka Sare ee plasma ku kordhinaya horumarka habka atherosclerosis iyo wadne xanuun.

Waayo, siday daaweyn hoos u egyahay isticmaalaya hab gaar ah, mid ka mid ah taas oo ah daroogada "Atokor". Tilmaamo ku saabsan dawadan waxa qeexayaa doorka hypocholesterolemic iyo gipotriglitseridemicheskuyu yaraynta fiirsashada ee kolestaroolka waxyeello iyo dufanka kale ee jirka aadanaha.

sifooyinka Guud

Daawada waxaa loola jeedaa inhibitors ee reductase 3-methylglutaryl-3-hydroxy-CoA. "Dr. Reddy ee Laboratories" waxaa la soo saaray by shirkad Indian.

In diyaarinta "Atokor" qiyaasta laga yaabaa in 0,020 oo 0,010 g

Form sii daayo

Wakiilka soo saaray qaab kiniin dahaarka leh kula film cad. Kiniiniga extruded qaab xagal leh dusha biconvex a on mid ka mid ah oo xarafka "A" waxaa laga codsadaa, iyo kuwa kale ee la qoondeeyey sida dose oo ah "10" ama "20".

Qaab-dhismeedka

Walaxda firfircoon ee daroogada waa atorvastatin, oo ay matalayaan trihydrate calcium micronized. In daawada "Atokor" qiyaasta iyo Halabuurka of qayb taranta firfircoon wax yar ka duwan. 0,01084 ama 0,02168 kasta g of atorvastatin calcium trihydrate u dhiganta 0.01 ama 0.02 g of atorvastatin saafi ah.

sonkorta caanaha, carbonate calcium, sodium croscarmellose, polysorbate 80, cellulose hydroxypropyl, lactose DT, milmahayn magnesium dhismeedka kiniin la aasaasay ah.

Filimku wuxuu sanduuqa battariga soo sameeyey hypromellose 15 CPS, tones propylene, Rusheyn kartaa la safeeyey, titanium dioxide.

The isku mid ah labada dose oo macnaheedu yahay "Atokor" halabuurka, iyo hanuunin ay total.

Loox oo 0.01 ama 0.02 g of 10 xabbadood ayaa la soo saaray ee khariidad-soo baakadeeyey ee kartoon ah.

hab of action

edbinta Daawooyinka on codsiga Qisoon xushay, retarders tartan 3-methylglutaryl-3-hydroxy-kofermentaA reductase. Waa enzyme muhiim u ah beddelidda ee xarunta 3-hydroxy-3-metilglyutarilkoenzima A a in mevalonic acid taas oo ka horreeyaa styrenes iyo kolestaroolka.

Haddii bukaanka ee hypercholesterolemia, qoys iyo non-qoys heterozygous homozygous, iyo dyslipidemia isku qasan, qaadashada daroogada "Atokor" waxay ka caawisaa in la yareeyo kolestaroolka guud ahaan, qayb ka kolestaroolka ee Lipoproteins ee mugga hooseeya iyo aad u yar yahay, dufanta iyo apolipoprotein B.

Medicament "Atokor" description daroogada waxay muujinaysaa iman kara ah kiniin deganayn waxtar leh si loo kordhiyo heerka sterol in Lipoproteins la cufnaanta sare.

In unugyada beerka, iyo triglycerides holesterolovye taagoo noqday qayb muhiim ah oo walxaha lipoprotein lahaynu cufnaanta hooseeyo xoog leh. Waxay waxaa loo dirayaa plasma ah, kaas oo dhex gelin galay nudaha durugsan. Xeryahooda, kuwaas oo la aasaasay lipoprotein la robab yar yahay dareen-celin catalyzed awoodi la xidhiidh buuna sare qaababka nooca receptor. All of walxahan waxay kobcin karaan horumarinta cudurka atherosclerotic.

Action Atorvastatin waxa lagu gartaa ay kor ugu kaceen oo joogto ah tayada oo ka mid ah kaxeynayo LDL-receptor, yaraynta uruureen kolestaroolka waxyeello at hypercholesterolemia kacsantahay nooca la iska dhaxlo homozygous.

Oo macnaheedu yahay "Atokor" edbinta muujinaysaa awoodda si loo yareeyo heerka kolestaroolka plasma iyo lipoprotein by anada enzyme reductase HMG-CoA. Waxaa caanuhu formation of kolestaroolka in unugyada beerka, waxay kordhisaa tirada qaababka receptor of Lipoproteins la robab yar xuubka unug ka. Tani waxay kor u soo qabtay iyo catabolism ee kolestaroolka ka taagoo lipoprotein fiirsashada hoose.

Maxaa loo isticmaalaa

Medicament "Atokor" Codsiga User taliya kiniin qaadashada at calaamadaha aasaasiga ah ee kor u kacay cholesterolemia nooca heterozygous, sii kordhaya fiirsashada kolestaroolka deegaanka iyo xaafada ahayn, geterlipidemii isku qasan, lacagta kor u taagoo triglyceride plasma.

Waxay waxaa maamula isku dhafan oo barashada cuntada hoos heerka kolestaroolka sare ee Lipoproteins la robab yar yahay, apolipoprotein B iyo xeryahooda triglyceride.

Kiniiniyada loo yareeyo fiirsashada plasma ee kolestaroolka in cholesterolemia LDL ee Qolol nooca qoys homozygous, marka cuntada cuntada iyo hababka kale ee aan pharmacological xumaada.

Sida loo qaato

Medicament "Atokor" tilmaamaha loo isticmaalo ku talinaysaa in la cabo oo kaliya ka dib markii ballan qofka caadiga ah cunto hypocholesterolemic buka, oo waa in la isticmaalaa inta lagu jiro daaweynta. Qadarka Qaadashada si gooni ah loo dhigay bukaan kasta, oo waxaa loo xisaabiyaa on heerka bilowga ah ee kolestaroolka in Lipoproteins la robab yar yahay. Waxaa muhiim ah in ay tixgeliyaan isticmaalka loogu talagalay, waxtarka daawaynta la "maragga Atokor '.

Sida caadiga ah, qiyaasta hore u dhiganta 0.010 g hal mar maalintii. Isticmaalka kaniiniga aan ku xidhan tahay waqtiga maalinta iyo cuntada.

qiyaasta ayaa ka mid ah hab oo maalin walba 0,010 in 0,080 g waxaa ka tilmaamayaasha xisaabaadka hore ee kolestaroolka waxyeello, goobaha bartilmaameedka iyo xulay waxtarka qof ahaaneed. In wajiga hore ee arjiga iyo iyadoo la kordhinayo fiirsashada of daroogada waa in bil badh hubiyo heerka dufanka plasma, iyo qabsato qiyaasta hadba sida loogu baahdo.

hypercholesterolemia Hoose iyo isku daro qof hyperlipidemia loola dhaqmo qiyaasta maalinlaha ah ee 0,010 g

hawl-daweynta dhacdaa 14 maalmood gudahood, iyo hufnaanta ugu badan waxaa suurtagal ah ka dib markii muddo hal bil ah. isticmaalka daba dheeraaday waxay fursad si ay u ilaaliyaan saamaynta ku daweynta.

Daawooyinka "Atokor" buugan Ruush qoran warar ku saabsan terapiigiperholesterinemii nooca qoys homozygous. Sida caadiga ah, qiyaasta maalinlaha ah qoray in 0.080 g In isticmaalka this waa hoos u dhac in qiimaha kolestaroolka LDL ilaa 40%.

Features ee daaweynta

Kiniinnada "Atokor 'tilmaamaha loo isticmaalo waxaa si xoog leh lagula talinayaa inta aadan bilaabin si ay u isticmaalaan daroogada waa in la helo sababta keentay koror sare ee qiimaha kolestaroolka. qodobada waxaa ka mid ah cudurka macaanka, si xun laguu daaweeyo sonkorowga, hypothyroidism, nephrotic isbedel disproteinemicheskih nidaamka, cudurka beerka obstructive. Tani waxay ka mid noqon kara daaweyn dheeraad ah daawooyin kale iyo qabatinka aalkolada. Kaliya ka dib markii laga takhaluso oo ka mid ah sababaha kor ku xusan, aad diyaar u yihiin in ay isticmaalaan kiniin "Atokor".

Xitaa ka hor therapy waxaa la sameeyaa go'aan kafado la egyahay inta u dhaxaysa kolestaroolka guud, kolesteroolka LDL ee kolestaroolka in HDL iyo triglycerides.

Ma jiraan wax xog ah oo ku saabsan isticmaalka daawooyinka ee tirada cudurada carruurta, si kiniiniyada, kuwaas oo aan la tilmaamay ee carruurta.

In daaweynta bukaanada waayeelka ah, kuwaas oo da'doodu ka badan tahay 60 sano, waa in la kordhiyo heerarka plasma of qayb ka wakiilka firfircoon si ay 40%.

In case of xadgudub ku shaqaynaya kelyaha muhiim ma aha si ay ula qabsadaan qiyaasta, sida xaaladan wax saameyn ah kuma content atorvastatinovoe ee dhiigga iyo waxtarka hoos kolestaroolka xun.

Waxaa jira cadaymo muujinaya in isticmaalka class this daroogada keeni myopathy rabdomioliznoy horumarka iyo shaqada kelyaha ku filnayn qaab daran. In cuduradaan by daawada waa in la tuuraa waqtiga.

Diyaargaraw ku saleysan atorvastatin waa in si taxadar leh loo qaaday dadka dhiba khamriga ama uu kugu dhacay cudur beerka ee la soo dhaafay.

tallaabada of celiyeyaasha of HMG-CoA enzyme reductase waxaa laga yaabaa in isbeddel ah ee Tilmaamayaasha lagmamaarmaanna u ah beerka. Waayo, rakibaadda waqtigii xadgudubyada sida u baahan tahay si ay u qabtaan qiimeynta dhaqdhaqaaqa cagaarshowga, ka dibna 3 bilood ka dib qaadashada kiniinka ka fuliyaan jeeg ka hor daaweynta.

Drug "Atokor" on edbinta Ruush waxaa ka mid ah macluumaadka ku saabsan kor ugu kaceen qiimaha plasma of qayb firfircoon ee bukaanka qaba cudurka beerka, ay dhibaatadu ka Khamriga. failure ku meel gaar ah ama dhamaystiran oo therapy laabtay dhaqdhaqaaqa transaminase beerka ee ku yiilleen asalka ah. Bukaan badan ma joojin isticmaalka daroogada in yar ka qaataan, oo ma dhibaato waajibo.

In daaweynta waxaa laga yaabaa in ay dareemaan wareer, horumarinta hurdo, sidaa darteed waqtiga codsiga dadka bukaanka ah kiniin waxaa ka mamnuuc ah in la xakameeyo gaadiidka iyo qalab kale oo adag.

Yaa waa in aan u isticmaali

On medicament sababo "Atokor" waxaa ka mid ah dareenka ee la kordhiyey si ay qayb kasta oo ka mid medicament ah.

Ma uusan qaadan dhacdo cudurka beerka ba'an iyo dardargelinta sare ee falgalka serum transaminase marka ay hawl waa 3 jeer ka badan xadka sare ee qiimaha caadiga ah.

Daawada waxaa aan qoray in haweenka ku jira da'dii dhalmada oo aan la isticmaalayo ka hortagga uurka ku filan. Contraindication waa xaalad ka mid ah dhalmada iyo naas-nuujinta.

Daawada ma daweeyo carruurta iyo dhallinyarada ka yar 18 sano jir.

Sababo la xiriira joogitaanka caanaha ee halabuurka ah ee Atokor "edbinta sonkorta kiniiniyada 'on codsiga mamnuucaya isticmaalka iyaga ka mid ah in dulqaad la kala dhaxlo in u taagoo galactose, iyadoo la'aanta lactase iyo malabsortsii glucose-galactose.

analogs

Waxaa jira tiro badan oo ah daroogada ku saleysan atorvastatin. Cholesterol-hoos doorka daroogada si "Atokor" diiwaanka. Analogs sidoo kale ay awoodaan in ay hoos u heerka kolestaroolka xun ee dhiiga.

Mid ka mid ah daawada sida daawo loogu talogalay Slovenia "Atoris", taas oo ah soo saaraha ah ee shirkadda stock wadajir ah "Mesto Krka, Novo." Waxaa la soo saaray qaab kiniin la content firfircoon qayb ka mid ah 0.010 g, 0.020 g, 0.040 g

Daawada waxaa loogu tala galay in la baabi'iyo xaalad hyperlipidemic, kuna waari dhexdeeda xuduudaheedu lagama maarmaanka ah si loo yareeyo kolestaroolka total, kolestaroolka lipoprotein in xeryahooda la robab yar, cadadka apolipoprotein oo u taagoo of triglyceride ee dhiigga.

dawayn Drug dadka qaba hypercholesterolemia polygenic nooca qoys homozygous heterozygous.

Iyada oo taageero ka "Atoris" daroogada wuxuu kordhiyaa-fiirsashada ee kolestaroolka in Lipoproteins la robab sare.

analoogga kale Slovene tixgeliyo daroogada "Tulip," taas oo hadda noqday "Lek Pharmaceutical Company". Waxaa jira saddex qaadashada kiniinada dahaarka leh: 0.01 g, 0.02 g iyo 0.04 g

Daawada waxaa lagu tilmaamay for tirtiridda foomamka hoose ee hypercholesterolemic iyo xaalad hyperlipidemic isku daro, waayo, daaweynta ee kolestaroolka kacsantahay qiimeeyo heterozygous iyo nooca qoyska homozygous.

Sidoo kale, hab loo arkaa daawo Indian "Astin", kaasoo lagu soo saaro by shirkadu "Micro Shaybaarka Limited". Waa la heli karo in labo qaadashada, at 0,010 g iyo 0,020 g of atorvastatin.

Daawada waxaa laguu qoray ee ah content la egyahay kordhay, marka aan lagu arkay saamaynta wanaagsan ee dhacdooyinka cuntada iyo kale.

Indian saarta medicament ah "Storvas" ku salaysan cusbo calcium ee atorvastatin ah. Macmalay by "Ranbaxy Laboratories Limited" oo ah qaab kiniin ah dahaarka leh kula galkeeda ah in laba qaadashada, at 0,010 g iyo 0,020 g

Drug "Storvas" yareeyo content sare oo kolestarool ah total, u taagoo kolestaroolka LDL ee, iyo ka-fiirsashada ee xeryahooda triglyceride apolipoprotein ee aasaasiga ah, iyo xaaladda nonmarried hypercholesterolemic qoys heterozygous, iyo sidoo kale cudurka hyperlipidemic isku qasan.

Daawada yaraynaysaa suurtagalnimada ee Wadnaxanuun myocardial infarction gobolka cajiib ah oo ka mid ah murqaha, stroke iyo isbeddel ah ee socodka dhiigga maskaxda. Kiniiniga hakin horumarka xaaladda atherosclerotic wadnaha.

dhigiisa American waa "Lipitor" daroogada waxaa soo saaray "Pfizer". Waxaa la soo saaray qaab kiniin dahaarka leh qolof ah saddex qaadashada, at 0.010 g, 0.020 g, 0.040 g Daawada waxaa sidoo kale loo isticmaalaa in lagu baabi'iyo dalalka hypercholesterolemic noocyada kala duwan ee ka soo jeedo.

Reviews

Daawo "Atokor" Codsiga User sharaxayaa sida loola jeedaa la oggolyahay xaqiijiyay sare. Bukaan badan uruureen plasma kacsantahay oo kolestarool ah waxyeello, ka dib markii koorsada isticmaalka waa uu sii fiicnaanayaa. The qiyamka kolestaroolkaaga guud iyo kolestaroolka LDL la yareeyo heerka caadiga ah, taas oo yaraynaysa fursadda horumarinta atherosclerosis, iyo xaaladaha ischaemic.

daroogada iska leh warbaahinta la tolerability wanaagsan, laakiin qaar ka mid ah bukaanada waxay keeni kartaa saxaro ah dib u dhac, dibiro, xanuun caloosha, yaqyaqsi, saxarada ah. Waxaa jira madax-xanuun, hurdo. Waxaa laga yaabaa in la horumariyo matago, asthenic iyo xaalad myalgic.

Marar dhif ah, waxyeelo yihiin myositis muujiyey, myopathy, paresthesia, neuropathy durugsan, ganaca, hepatitis, joonis cholestatic.

Kiniiniga keeni kartaa anorexia, matag, daliilka hepatotoxicity, alopecia, daliilka pruritic of finan, impotence, caadka, barar aad ama hypoglycemia.