Daawada "Letrozole": diiwaanka, dib u eegista iyo analogues

Waayo, waa maxay ujeedada bukaanka daawada 'Letrozole' waa la magacaabi karaa? Tilmaamaha loogu isticmaalo daroogada waxaa lagu tilmaamay faahfaahsan ee qodobkan. Sidoo kale, waxa ku jira macluumaad ku saabsan sida badan waxaa xusid mudan daawada, haddii uu wax analogues, dhibaato iyo sababo isaga, bukaanka iyo wixii la mid ah D..

The qaab, sharaxaad, halabuurka, baakadaha

Maxay ka dhigan tahay 'Letrozole' diyaarinta? Medicine, loo arkaa noo by, waxaa ku jira qayb firfircoon ee isku magaca. Waxa kale oo ka mid ah qaybaha kaabayaal sida cellulose, laktosmonohydrat lactose, istaarijka, sodium noqde carboxymethyl, silica ammooniya Kolloidol iyo milmahayn magnesium.

daroogada Tan waxaa loo suuq sida kiniin ah-dahaarle mugdi-jaalle. Waxay yihiin qaab wareeg ah oo lenticular.

Drug "Letrozole ', qiimaha kaas oo hoos ku qoran, waxaa lagu gadaa baakadaha ee dusha, waxaa la geeyaa raso baakado.

Sidoo kale waa in la ogaadaa in ku xiran saaraha loo arkaa daroogada waxaa laga yaabaa in a qaab oo kala duwan, baakadaha iyo xirxirida.

pharmacodynamics daroogada

Waa maxay astaamaha uu leeyahay daroogada 'Letrozole'? Tilmaamaha loogu isticmaalo sheegayaa in ay tahay wakiil antineoplastic in uu hakiyo ereygu wuxuu ahaa ee estrogen.

daroogada Tani eegista hakiyo aromatase, taas oo ka dhigan ereygu aad u muhiim ah enzyme noolaha estrogen. Tani waxay dhacdaa sabab u ah a heer sare ah oo gaar ah ku qabanaya in ay xubno ka enzyme yiri.

Sida laga soo xigtay waxbarashada, "Letrozole" awood u anada biosynthesis ee Østrogen in burooyinka iyo unugyada durugsan caafimaad.

At jinsi ah caddaallad ah ee estrogens postmenopausal waxaa la soo saaray iyadoo ka qaybgalka tooska ah ee aromatase. Waxaa badalaa androgens in estrone oo estradiol, in kacayaan qanjidhada adrenal.

soo dhaweynta habboon ee medicament ah (maalintii 0.1-5 mg a) keenaysaa in hoos u dhac in fiirsashada dhiigga sulfate estrone, estradiol oo estrone ee 95% ka mid ah content hore. Xaaladdan oo kale, ereygu wuxuu ahaa ee estrogen waa in la baabi'iyay therapy oo dhan.

Iscelin of ereygu wuxuu ahaa ee estrogen kordhiyaa-fiirsashada ee androgens, kuwaas oo ah, dhab ahaantii, ka wakiil ah barametereka kiimikada ee estrogens.

Waa maxay qaababka kale daroogada "Letrozole?" saaraha ayaa sheegay in inta lagu guda jiro daawaynta wakiilka this ee degree yar oo ah inta jeer kor u osteoporosis.

daaweynta Curiyaha taageerada ee kansarka naasaha hore si weyn u yaraynaysaa halista ah ee ku xoogeystay iyo kordhinta badbaadada 5 sano oo aan wax calaamado muuqda oo horumar. Sidoo kale, daroogada this yaraynaysaa fursad of metastasis iyo burooyinka sare.

therapy Curiyaha taageerada joogtada ah tani waxay ka dhigan yaraynaysaa halista ah ee ku xoogeystay by saabsan 42%.

Pharmacokinetics

Halkee nuugista qaadataa meel "Letrozole 'diyaarinta? Tilmaamaha loogu isticmaalo uu inoo sheegayaa in ka dib markii maamulka afka daroogada halkii si degdeg ah oo si buuxda u nuugo ka mindhicirka. Its bioavailability celcelis ahaan 99.9%. Xaaladdan oo kale isticmaalka cuntada aad u yaraynaysaa heerka nuugo.

Time of dhacdo of fiirsashada ku badan yahay dhiigga ahaa 60 daqiiqo inta aad qaadanaysid daawada calool madhan iyo 120 daqiiqo at dhaweynta wada jir ah ula cuntada.

Isgaarsiinta la protein plasma gaaro 60%. raasamaal oo ah walaxda firfircoon isticmaalka daba dheeraaday ee daawooyinka aan la calaamadeeyay.

Dheef-Drug kaaga formation of metabolite firfircoonayn. Its tirtiridda waa la fuliyay in kaadida, iyo sidoo kale iyada oo loo marayo mindhicirka. Nolosha nus ka mid ah daroogada waa 2 maalmood.

Tilmaamayaasha

Waayo, daaweynta cudur kasta oo la isticmaalayo daroogada sida "Letrozole?" khubaro Guest sheegaya in muujinaya in loo isticmaalo qalab this waxaa soo socda cudurada:

• neoplasms malignant naaska ku jira marxaladaha hore ee therapy postmenopausal marka la dhameystiro heerka "tamoxin" (loo isticmaalo sida lagu daaweyn dheer oo dheeraad ah).
• neoplasms malignant naaska ku jira marxalad hore (koritaanka buro lagu kiciyaa by estrogens) ee postmenopausal ee galmada caddaallad (isticmaalaa daawaynta oo dheeraad ah).
• kansarka Common kansar naasaha postmenopausal dadka hore u heshay daaweyn la antiestrogens.
• Noocyada caadiga ah ee carcinogenic naaska hormone-tiirsane ah ee postmenopausal (therapy-line hore).

sababo

Under waxa xaaladaha laguma qaadi karo "Letrozole?" Analogs daroogada iyo daroogo laftiisa, laguma talinayo inay dadka qaba:

• xaaladda hormoon, caan muddo barwaaqaysan ;
• naas-nuujinta,
• wacyigelin in walxaha daroogada aasaasiga ah iyo dheeraad ah;
• uurka;
• ee carruurnimada.

Sidoo kale waa in la ogaadaa in si taxadir leh xad-dhaaf ah la siiyo daawada loo isticmaalo deficiency lactase, lactose, iyo sidoo kale u nuugeynin glucose-galactose ah.

Daawada 'Letrozole': tilmaamaha loo isticmaalo

In waxa qiyaasta qoray daroogada ee su'aasha? Joogtee soo dhaweynta ah ee daroogada noocan oo kale ah waa in kaliya la dhakhtar soo qoray. dhakhtarkaaga in, ku salaysan falanqaynta xogta iyo baaritaan caafimaad guud ahaan, waa in ay go'aamisaa qiyaasta kiniinka iyo inta jeer ee ay u isticmaalaan.

"Letrozole" daaweynta kordhiyay muddo dheer. Daawada waxaa laga qaaday afka, iyadoo aan loo eegin cunto qaadashada. Sida laga soo xigtay edbinta, qiyaasta lagula taliyey of daroogada waa 2.5 mg maalintii hal mar.

Daawada waa in la qaataa maalin kasta muddo 5 sano ama ilaa labakaclaynta.

Haddii daawada loo isticmaalo in ay goob Waxuu curiyaha, qaadashada kiniinka waa in la sii muddo 4 sano ah. Iyadoo horumarka ee medicament kansarka waa la afgembiyi doonaa.

In dadka jinsi taagta daran qaba kansarka ee marxaladda la soo dhaafay, ama la caddayn therapy xadka- waxaa looga baahan yahay in ay sii wadaan ilaa horumarka buro waxaa loogu dhawaaqaa.

xaaladood oo badinta

Haddaba aad u ogaato sida loo sameeyo 'Letrozole'. Si kastaba ha ahaatee, tani waa in sameeyey oo kaliya ka dib markii la tashanaya takhtarkaaga. At qaadasho sare ee dawooyinka laga yaabaa in bukaan horumarinta Waxyeellooyin. Currently, waxaa jira tiro ka mid ah xaaladaha badinta daroogada loo arkaa.

Sida daaweynta xaaladaha sida isticmaalaya daryeel taageero ah iyo calaamadaha. hababka gaarka ah si loo baabi'iyo calaamadaha xad dhaafka ah aan la horumariyo. Kala noqoshada daroogada ka dhiigga by kelyaha.

medicament The "Letrozole": dhibaato

Qof kasta oo dhibaato ka dhacaan ka dib markii maamulka ee daroogada 'Letrozole'? kaniiniyada Anticancer inta badan keenaan waxyeelo aan loo baahnayn. Ka fiirso liiska iyaga hadda:

• nidaamka dheefshiidka: calool xanuun, stomatitis, shuban, dyspepsia, ay hawshooda u ah falgalka cagaarshowga, lalabo, afka oo qalala, calool, matag.
• habdhiska: somnolence, dawakhaad, paresthesia, murugada, xusuus lumid, welwel, hurdo la'aan, caro, hypoesthesia, rabshooyin yaacsanaan marayay in wareegga cerebral, dysesthesia.
• neefsashada, qufac, neefta oo ku qabata.
• nidaamka hemopoietic: leukopenia.
• Falcelinta maqaarka: alopecia, dhidid, urtikaria, ficil-celintan jirka, finan, anjioedema, maqaar qalalan, cuncun.
• nidaamka wareegga dhiigga (qalbiga) wadne xanuunka, tachycardia, thrombosis, uurkuna waa, thrombosis halbowlaha, lungemboli, thrombophlebitis, maqaar saar oo qoto dheer thrombosis xididka, stroke, sii kordhaya cadaadiska.
• Nidaamka muruqyada: osteoporosis, arthralgia, arthritis, myalgia, jab, lafaha xanuun.
• Fistula: cudurada kala duwan, kaadida oo soo noqnoqda, dheecaanka hoosta haweenka, dhiigbax, xanuunka xabadka.
• Dareemeysaa: qasnaan dhadhanka, caadka, aragga indhaha oo isku darsamay.
• Dareen-celinta kale: xub-axaleedka qalalan, barar guud, dareenka gubashada ah paroxysmal, qidmeyntiibulshada, daal, pyrexia, asthenia, xanuun lesions buro iyo bararka durugsan.
• -Shiid: miisaanka oo kordha, miisaanka oo yaraada, hypercholesterolaemia, anorexia, rabitaanka cuntada oo kordhay, harraad joogto ah.

isdhexgalka Drug iyo talooyin gaar ah

tijaabo u helo warbixinta daawada isku dhafan oo daroogo kale anticancer ayaa la sameeyay.

Isticmaalida "Letrozole ', taas oo dib u eegista lagu qaso, waxa ay si xun u saamayn karaa awoodda qofka inuu kaxeeyo, iyo sidoo kale shaqada leh habab adag.

Aqbalaada daroogada ee Isboortiga

Medicament 'Letrozole' bodybuilding waxaa loo isticmaalaa ilaa xad inta badan. ciyaartoyda qaar badan ayaa sheega in qaadashada daroogada sida ay keenaysaa in ay is hortaagaan ereygu wuxuu ahaa ee estrogen, iyo kordhiyaa wax soo saarka ee androgens. Si kastaba ha ahaatee, khubarada khibrad ku doodaya in dambaysta ah waa tarin aan la cilmi ahaan la xaqiijiyey. In xiriir this, dhakhaatiirta, waxaa laguma talinayo in ay isticmaalaan 'Letrozole ee bodybuilding. Marka hore, waxa uu leeyahay tiro ka mid ah sababo gaar ah, iyo marka labaad, medicament firfircoon leeyahay tiro badan oo waxyeelo.

Sidaas darteed, maamulka mawduuca ah daroogada qoray ka dib markii aan waxaa muujinaya Orodyahanka si weyn hoos u dhici karta.

kaydinta iyo sale xaaladaha, nolosha shelf

Halkee ayaan ka iibsan kartaa daawooyinka 'Letrozole'? Analogues qalab this iyo diyaarinta laftiisa lagu iibiyo ku dhowaad dhammaan iska-. Si kastaba ha ahaatee, wuxuu si adag u sii daayay qoro.

Ka dhig medicament ah suurad wacan in qalalan, meel gudcur ah ee ilaa heerkulka a ilaa 25 darajo, halkaas oo ma jiraan wax ay helaan carruurta yaryar. Nolosha shelf ee daroogada waa 24 bilood. Mudadaas ka dib daawada laga yaabaa in aanay u isticmaalin.

Kharashka iyo canshuuraha ee daroogada

Ma la socotaa sida ay kukacayaan daroogada 'Letrozole'? Qiimaha daroogada this yar kala duwanaan karaan ku xiran tahay gobolka, xadad soo saare iyo network farmashiyaha. celceliska kharashka daawooyinka anticancer sida uu yahay 1500 rubles (30 kiniin). Si kastaba ha ahaatee, qiimaha waxay khuseysaa oo keliya in diyaarinta soo saarka gudaha. medicament ee shirkadda Isbaanish "Kent Pharma" wax badan oo qaali ah (oo ku saabsan 2600 rubles).

Marka la eego in kaniiniyada "Letrozole" (waxyeelo ayaa kor lagu sharaxay) in la qaado in ka badan dhowr sano, daaweynta carcinogenic kharashka bukaan aad u qaali ah.

Qaar ka mid ah bukaannada aan awoodin in ay iibsadaan daawada loo arkaa, bedeli siyaabo kale (oo kaliya ka dib markii la tashanaya dhakhtarkaaga). By analogues daroogada sida waxaa ka mid ah daawooyinka hoos ku qoran: "Aralet", "Etruzil", "Lerzy", "Femara," "Letrozole Teva", "Letrotera", "Letromara".

Waa in la ogaadaa in qiimaha dawooyinka u noqon karaan sare asalka iyo hoos. Tusaale ahaan, 30 kiniin oo ah daawada qiimaha "Femara" oo ku saabsan 7700 rubles ah. Si kastaba ha ahaatee, ay hufnaani ka tahay aan wax badan ka badan in ka mid ah "letrozole".

Daawada bukaanka

Raadi dib u eegista bukaanada diyaarinta loo arkaa waa ay adag tahay. Dadka qaba kansarka waa ka maagaan in ay la wadaagaan natiijooyinka daaweynta. Inta badan oo iyaga ka mid ma maareeyo si ay u gaaraan dembidhaafka. In kasta oo bukaanka ka mid ah waxay ku andacoodaan in daroogada 'Letrozole' weli siiyey iyaga rajo nolol dheer.

Sida khubarada, dib u eegista ay tahay kaliya mid fiican. Iyada oo ku saleysan adduunka laga aqbalay oo la xaqiijiyay xogta cilmi ahaan sax ah, ay ku andacoonayaan in ka mid ah oo dhan daroogada antineoplastic "Letrozole" medicament waa habka ugu waxtarka badan ee daaweynta ee burooyinka naasaha malignant.

Sidoo kale waa in la ogaadaa in bukaan badan qiimaha daroogada this murugoodo. Inta badan oo iyaga ka mid ma awoodaan in ay iibsadaan daawada ah in way sii xumaysaa waxayna xaaladda dareen si aan degganayn. Si kastaba ha ahaatee, farmashiistayaasha ku doodaya in technology u gaar ah wax soo saarka ee kiniiniyada sida aan u oggolayn in ay dejiyaan qiimo ka jaban.

Sida waxyeellooyin, sida ay fikrad ah ee bukaanka ah, iyaga oo aan ka muuqan sidaas fahmayaan, sida ku cad tilmaamaha (gaar ahaan ka dhanka ah asalka ah oo ah xanuunka jira). Inta badan, daroogada this keeni kartaa lallabo, tachycardia, urtikaria, caro iyo shuban. Si kastaba ha ahaatee, dadka intooda badan qaadashada kiniiniga kuwan, diyaar u yihiin in ay u adkeystaan oo dhan waxyeelo ka, haddii oo keliya daaweyn muddada-dheer ayaa ka qayb qaatay horumarinta dembidhaafka.