Immunoglobulin The G, micneheedu waa maxay haddayan nin?

Waayo, la dagaalanka infekshanka ee jidhka bini'aadamka u dhiganta arrimo dhowr ah. Mid ka mid ah meelaha ugu muhiimsan ee nidaamka this iska leh immunoglobulin ah, ama in badan sax ah, immunoglobulin noocyada G. kale ee immunoglobulins, IG G ahaa awoodaan si ay u ilaaliyaan jidhka ilmaha dhashay cudurka, sida uu leeyahay awood u leh inay dhex gasho iyada oo dhiigga hooyada iyada oo mandheerta, gasho dhiiga ilmahaaga.

Britain ayaa waxay ka kooban tahay IG G subunit, oo miisaankiisu yahay qiyaastii 150 KD. In dadka iyo in jiirka, ku tilmaamay afar Banii-, kaas oo la immunoglobulin G. Waxay marka hore laga helay by hababka fuliyo. Gobolka faseexad immunoglobulin lagu gartaa tiro badan oo ku harta cysteine iyo Britain proline ah, taas oo ay go'aamiso ay dabacsanaan. bonds Disulfide in qayb ka mid ah ee Britain ayaa ku leeyihiin kala duwan, oo ay ku salaysan globulin subclass ah. Sayidka, gamma 1 iyo gamma globulins 4 leeyihiin laba bonds disulfide, gamma 2 - afar gamma 3 - kow iyo toban. gamma 1 silsilad gobolka faseexad The billaabay kaliya ka hadhay ee 216-th iyo dhammaanaysaa 231-m. Gobolka faseexad A gamma silsilad 3 yaal afartan toddoba harta dambayn 1. gamma Study siiyey xigxiga acid amino waxay suuro gelineysaa in loo qaato in la kordhiyo la mid ah ee ku harta la xidhiidha meelaha yaac iyo double 216-231 gamma 1 silsilad. Gobolka faseexad waxay leedahay singularity muhiim ah: isdhexgalka iyada oo labada silsiladood oo culus dhacdaa iyo qaab-dhismeedka octapeptide xilliile adag, taas oo u adeegta sida dhidibka wareeg ee gobolka faseexad dabacsan oo dhan, iyo halkan for seegtayd-jajabkii in ay yihiin lagama maarmaan si ay ula falgalaan hannaanka ah cudur.

Dejinteedu IG G dhacdaa inta lagu jiro jawaabta difaaca jirka hoose iyo kuwa sare, sida noocan ah antibody waa mid aad wax ku ool ah dhex gasho galay nudaha, waxaa xidhana iyo markii danbe laga saaro cudur shisheeye.

Waayo, ilaalinta bakteeriyada ee jidhka bini'aadamka jawaab sax ah immunoglobulin G. heerka noocan ah globulin waxaa laga yaabaa in kiisaska nidaamka difaaca jirka ayaa horay u soo galeen xiriir la cudur shisheeye oo bilaabay inuu wax soo saarka firfircoon ee antibodies. Sidaas darteed, korodhka arkay in tirada immunoglobulins waqti bilaabi kartaa cudurka waqtiga iyo daaweynta cudurrada keeni noocyo kala duwan oo bakteeriyada iyo fayraska.

Shaqada ugu weyn ee immunoglobulin noocan ah waa ilaalinta jidhka bini'aadamka ka wakiilada ajnabiga ah wuxuu keeni karaa cudurada faafa. Immunoglobulin G sida wareer ah dagaal naftooda iyo wax soo saarka ee ay dheefshiidka by opsonization, nidaamyada la bilaabay phagocytosis iyo ammaan.

Immunoglobulin G waa thymus-tiirsane, in uu ku dhexsameeysmo jirka ah thymus (thymus), la qaybqaadashada tooska ah ee T-limfosaytis. globulin nooca Tani waa qayb wayn oo jajab globulin dhiigga waxay tahay oo ku saabsan 80% dhammaan noocyada immunoglobulins. Sidaas darteed, soo dhaweynta ee immunosuppressants kala duwan, iyo sidoo kale soo-gaadhista boos ma ahan oo keliya si loo xakameeyo ereygu wuxuu ahaa ee IG G, laakiin sidoo kale in ay si buuxda u xakameeyo.

immunoglobulin G The, kaas oo caadi ah ee jirka ku kala duwan tahay kuna xiran tahay da'da 15 sano gaadho heerka final oo waa 8-17 grams halkii litir oo dhiig ah. Xaaladdan oo kale, immunoglobulins ah waa in ay noqdaan ma aha oo kaliya in dhiiga iyo wareejin jidhka oo dhan oo ay la socdaan dhiigga, waxay sidoo kale si fudud u geli karto meel ka extravascular, tan iyo fulinta dhammaan howlaha ay ka badan awood. Immunoglobulin G waxaa isku qaybiyeen labada ee dhiigga iyo unugyada kale ee jidhka gudahood, oon ku siinaya ilaalin ah u shaqeeyo cudurada.