"Torasemide": tilmaamaha loo isticmaalo. "Sandoz Torasemide": qiimaha, goobta, dib u eegista

"Torasemide" - casri ah daroogada awood lagu durayo in u san yahay, waayo, daaweynta muddada-dheer ee cudurada la xiriira muuqaalka kore ee barar. Sabab u tahay tirada yar ee waxyeelo caafimaad oo muhiim ah, ballaadhkiisuna wuxuu ahaa isticmaalkeeda daweyn dheeraad ah. Waa ammaan in diuretics kale loop oo uu leeyahay caddayn dheeraad ah. In daawaynta cudurada kala duwan qiyaasta la modified. Sidoo kale, waa lagu dabaqi karo in kiiska kaafi ah ee shaqada kelyaha xitaa at a nephrons glomeruli xawaare sifeynta hooseeyo.

Raadka "torasemide"

"Torasemide" sida a loop (cusbo) group wakiilka diuretics dhaqmaya qayb luminal of epithelium ee tubules of nephron ee qaybtii oo kor u kacaya of loop ee Henle ah. Dadkaas oo saamayn inhibitory gaadiidka wadajirka ah ee atammada potassium iyo chloride sodium, waxa si weyn u yaraynaysaa awood electrochemical at epithelium dusha of nephron ah. Natiijada Go'doominta waa qas gaadiidka ra'iyi nuugay sodium ka kaadida aasaasiga ah, taas oo kordhinaysa diuresis.

Dhammaan diuretics loop keeni rabshooyin elektrolytka sabab u nuugay ee saameyn xoogan oo udhigo potassium, sodium, magnesium iyo chlorine. "Torasemide" ilaa xad ka yar saamayn doorashada ee potassium iyo magnesium, ay sabab u tahay taas oo dhacdooyinka aad uga hooseeya baarutaan, anorexia, calool, tabar-dari muruq. Sidoo kale, daroogada si uu yar blocks xad formation of thromboxane A2, kordhin weelal. Waxa uu sidoo kale blocks aldosterone dhaweeyayaasha Wadnaxanuun, anada geedi socodkii fibrosis muruqyada wadnaha.

maragga

Lifaaqsan daroogada "Torasemide" diiwaanka waxaa ku qoran warar ku saabsan cudurka, taas oo uu si loogu daweeyo loo isticmaalo. "Torasemide" waxa lagu tilmaamayaa, waayo,

• daaweynta pathogenetic of hypertension halbowlaha adkaysi u therapy la isku of celiyeyaasha ACE (ARBs) diuretics thiazide;
• daaweynta wadnaha chronic, ku lug a wareegyada dollar wareegga dhiigga,
• daaweynta calaamadaha of kelyaha chronic, oo ay ku jiraan shaandeynta ee xawaaraha hooseeya (ka yar 20 ml \ min);
• daaweynta calaamadaha beerka (la hypoalbuminemia la xidhiidha) bararka ay badal u tahay "Furosemide".

Marka hypertension analogues "Torasemide" iyo xabbo waxaa loo isticmaalaa oo kaliya ka dib markii failure of diuretics thiazide. daroogada A duri karo waa muddo dheer, sababta oo ah tirada yar ee waxyeelo caafimaad oo muhiim ah oo u halista ah ee kelyaha. Kuwii "torasemide" waa wax badan ka yar in ee "Furosemide".

Tilmaamaha loogu isticmaalo

Iyada oo ku saleysan tilmaamo caafimaad oo loogu talagalay daawada "Torasemide" diiwaanka ka kooban yahay sifooyinka of qaadashada daroogada loo baahan yahay si loogu daweeyo iyo edbinta cudurka bartilmaameedka. War sidee daroogada laftiisa waa la heli karaa kiniin ay ku jirto maaddooyinka soo socda: 2.5 mg, 5 mg, 10 mg, 20 mg, 50 mg, 100 mg, 200 mg.

Si aad u qaadato daawada on loox subaxdii, iyadoo aan loo eegin hadhuudhka ah. Waayo, kuwaas oo qiyaasood oo ah daroogada "Torasemide" Qiimaha kala duwan, waayo, waa hoose ee qiyaasta ugu yar iyo kan ugu sarreeya ee ugu badan. Sida laga soo xigtay xogta celcelis ahaan, 30 kiniin oo ah daawada at 5 mg yihiin ku dhawaad 400 oo rubles. Marka la helo qiyaas waxaa loo qaybiyey sida soo socota sida laga soo xigtay tilmaamo ah:

• lagu daaweeyo hypertension qaaday 2.5 - 10 mg / maalintiiba;
• heshay 10-20 mg / maalintii wadnaha chronic,
• renal failure raaga - 50 mg ama ka badan;
• beerka u baahan tahay qiyaasta hagaajin shaqsi.

Waxyeellada "torasemide"

Lifaaqsan daroogada "Torasemide" diiwaanka ku jira macluumaad ku saabsan dhibaalka dhanka kale duwan. At qiyaasta-daweynta, sida ilaa 200 mg maalin kasta waxay kordhisaa halista jahawareerka thromboembolic, ischemia wadnaha, cerebral. Waxa uu kordhiyaa halista ah ee weerarada transient ischaemic iyo Wadnaxanuun myocardial, lungemboli, garaaca. Sidoo kale waxaa jira ixtimaal ah dhacdo of finan xasaasiyad ama finan markii cabista bukaan-socodka.

"Torasemide" mararka qaarkood sababa lalabo ama matag, dhif dhexdhexaadiyaan dyspepsia, shuban. Ku tilmaamay xaaladaha go'doon ah pankreatit inta lagu guda jiro daawaynta "torasemide". Sidoo kale kor u kacay transaminases cagaarshowga, taasoo muujinaysa sumoobo beerka daroogada ee qaadasho sare. Mararka qaarkood bukaan walwalsan ah oo ku saabsan dhaguhu dhegaha, aragga indhaha oo isku darsamay.

Marka aad hesho qiyaas sun horumarinta gobolka ee xad dhaafka ah oo leh calaamado yar. Iska badinta waxaa ku weheliyay khasaare ah dheecaan oo ku jira kaadida: diuresis dheer oo soo noqnoqda, waxa dhici karta in hypotension, vascular burburkii, suuxid, stroke, ischemia cerebral ee asalka ah.

Sababo iyo xadeynta codsiga

Drug analogues "Torasemide" iyo dawooyinka caamka ah looma isticmaali karo in joogitaanka sababo buuxda. Kuwani waa dareen xasaasiyad daroogada ama galalka. "Torasemide" mamnuuc in la isticmaalo in kelyaha la anuria, beerka halka ku jira xaalad ah miyir cagaarshowga, la tachyarrhythmias. qaadashada ahaan uu inta lagu jiro nuujinta iyo uurka, iyo sidoo kale da'doodu ka yar tahay 18 sano, diidmo in sulfonamides.

Side iyo saamaynta wadajirka ah "torasemide"

In daaweynta ee kaniiniga hypertension "Torasemide" yeelan kara saamayn xun ku koorsada of turqo. Tan iyo markii ay tubules proximal of nephron walaxda firfircoon daama gaadiidka firfircoon, waxaa jira Iscelin tartan rasmi ah ee Digo of uric acid. Against asalka ah isticmaalka "torasemide" itimaalka sare ee hyperuricemia iyo turqo ba'an.

Medicament "Torasemide" waxa lagu gartaa tallaabo gaar ah oo ku saabsan qayb ka proximal of loop epithelium embriyaha of Henle. Sababo la xiriira saamaynta iyo elektrolytka durayo dheelitir la'aanta xoogga this sababa suurtagalnimada isdhexgal pharmacological caafimaad ahaan muhiim ah. Waxay halis ah, aan qiimo lahayn oo suurad wacan yihiin. Waxaa ka mid ah khatar ah oo muhiim ah:

• dose sare (50 mg / maalintiiba) "torasemide" marka lala isticmaalaa diyaarinta platina wanaajisaa sumoobo doonana;
• qaadasho weyn "torasemide" (50 mg / maalintiiba) kordhiyo saamaynta nephrotoxic oo iyadana of antibiotics aminoglycoside;
• in antibiotics cephalosporin, marka lala isticmaalo "torasemide" ee dose oo ah 50 mg / maalintiiba muuqataa nephrotoxicity hantida;
• salicylates wada jir ah ula "torasemide" (50 mg / maalintiiba) lagu gartaa neurotoxicity.
• "Torasemide" ka dhanka ah asalka ah hypokalemia qof qaraabo ah u kordhiyaa nuglaato ee myocardium si glycosides wadnaha, kordhinta ay inotropic iyo saamaynta antiarrhythmic, sii kordhaya khatarta sumoobo,
• halista ah ee hypokalemia waxaa kordhay isticmaalka saameen "torasemide" la corticosteroids ama caloosha jilciya biyaha cusbada,
• "Torasemide" wanaajisaa saamaynta dabcineyso "theophylline" curariform iyo muruqa.

saamaynta doonayo ee isticmaalka isu geynta

Waxyeellooyinka la doonayo in u baahan tahay la socodka, waa hoos u dhac ku yimaadda cadaadiska dhiigga inta lagu guda jiro daawaynta celiyeyaasha ACE. "Torasemide" sabab u ah ka saarida ee dareeraha yaraynaysaa cadaadiska hydrostatic ee dhiigga si ay u dhexdhexaadiyaan hoos u dhac ku cadaadiska dhiigga. Qaybta Tani waa muhiim in daaweynta ee hypertension iyo waxay u baahan tahay sixida dose of celiyeyaasha ACE. Waxaa intaa dheer, in daaweyn jiray hypertension therapy u adkaysta iyo isku-dar ah inhibitor ACE "torasemide" noo ogolaanaya in la gaaro caadi ah ee dhiig-karka in 90% bukaannada.

In daaweynta wadnaha chronic waa saamayn caafimaad ahaan muhiim ah oo lagu yareeyo hawl vasoconstrictor catecholamines ah. Heart on therapy durayo asalka ah "torasemide" jawaab taagta daran si stimulatory calaamadaha adrenaline iyo noradrenaliin. Si kastaba ha ahaatee, saameyn la mid ah yareynta wax ku oolnimada epinephrine iyo norepinephrine inta lagu guda jiro dib u soo kicinta.

Saamaynta xun ee isdhexgalka

Waxaa u saameysaa oggolyahay Iscelin marka la isku daro walxaha qaar. Gaar ahaan:

• diyaarinta of sequestrants bile acid loo yareeyo qabashada "torasemide" mindhicirka, wiiqday saamaynta dambaysta ah;
• analgesics maandooriyaha (NSAIDs) yareeyo wax ku oolnimada "torasemide";
• "Probenecid" sabab u ah geeddi-weyneeye urikozuricheskih hakiyo doorashada "torasemide" in Lumen ee tubules ah, yaraynta ah waxtarkeeda.

sifooyinka barbardhiga "torasemide"

In diyaarinta analogs "Torasemide" waxay noqon kartaa fasalka, ogeed iyo xabbo. Ka mid ah analogues fasalka wakiil ah: "Furosemide", "bumetanide," "ethacrynic acid". In la barbardhigo "Furosemide" "Torasemide" waxa lagu gartaa bilawga la'ahay garoomada iyo saamayn dheeraad ah oo ku daba dheeraaday xiran diuresis kordhay. Bixinta saamayn lagu durayo waa ku dhawaad xoog la mid ah sida in of "Furosemide" "Torasemide" xasaasiya yartahay ee la xidhiidha dheelitir la'aanta elektrolytka degdeg ah.

"Bumetanide" waxa lagu gartaa hanti ah xataa xoog lagu durayo in waxa uu la xidhiidhaa waxyeelo badan. Ethacrynic acid leedahay saamayn heerka durayo hoose bilawga iyo waxaa dhif ah loo isticmaalo daroogada. The pharmacokinetics daroogada "Torasemide" dib u eegis ku takhasusay aqoonsan meel kale oo muhiim ah. daroogada waxay leedahay sifooyinka "kubadii": diuresis ka dib markii cod by qoondaynta sodium ma magdhawga ay haynta.

analogues Pharmacokinetic "torasemide"

The "Torasemide" guide daawo bixisaa macluumaad ku saabsan codsiga in bukaanka qaba dhiig-karka halbowlaha. Oo ay la socdaan daroogada, oo lagu daweeyo hypertension iyo waxaa sidoo kale loo isticmaalaa diuretics thiazide, potassium-jarin. Oo thiazide sabab si tartiib socda oo saamayn lagu durayo dheer waa daroogada ah ee doorashada.

In xidhiidh la leh pharmacokinetic kuwaas oo kasoo muuqday analogues diyaarinta "Torasemide" codsiga waxaa laga yaabaa in soo socda: daaweynta ee hypertension, adkaysi u therapy caadiga ah la isku inhibitor ACE (ama xanibaha receptor angiotensin) la thiazide ah. Sidoo kale, "Torasemide" waxaa loo isticmaalaa in lagu daaweeyo chronic renal failure leh awoodda sifeynta hoos.

Xabbo "torasemide"

In diyaarinta "Torasemide" diiwaanka, analogues, tilmaamo iyo sababo buuxda sifaha ay saameyn ugu weyn ee - diuresis kordhay. Waxaa intaa dheer, sida ficil ayaa daroogada asalka iyo generic. Arintaan waxaa ku jira tiro la mid ah "torasemide", laakiin saaray hoos magacyada kale ee brand.

The ugu caansan waa: "Britomar", "Diuver", "Sandoz Torasemide", "Trifas", "Torcida", "Trigrim". Intii lagu guda jiray baaritaanka ballaaran ee wakiilada pharmacological farqi weyn ayaa lagu arkay waxa u dhaxeeya ku Russia. Mid kasta oo ka mid ah daawooyinka ku xusan si buuxda u badalay kale oo ka mid ah.

dhinacyada dhaqaalaha ee daaweynta "torasemide"

In daaweynta ee hypertension markii diuretics thiazide ah ma yeeshaan isku dhafan oo celiyeyaasha ACE (ama ARBs), loo qaadan karaa daaweynta daawada "Torasemide": tilmaamaha loo isticmaalo doodaysaa dose hal inta lagu jiro maalinta. Qiimaha billaha ah ee daaweynta ku saabsan yahay 400 rubles at qiimaha 60 kiniin oo ah daroogada oo ku saabsan 760-800 rubles. Wixii la barbardhigo, qiimaha bil kasta ee daaweynta "Furosemide" dhif ka badan 20 rubles. Laakiin dambaysta ah ee daaweynta joogtada ah ee hypertension waa isticmaalka yar.

In wadnaha chronic la barar labada kharashka wareegyada wareegga daaweynta bil kasta "Furosemide" wuxuu ku saabsan yahay 20-30 rubles. In diyaarinta "Torasemide" Qiimaha waa 10-15 jeer ka weyn. Arintaan waxay leedahay saameyn khafiif ah, in ay tahay aan qiimo lahayn kordhiyaa Digo ee kaadida in saacadaha ugu horreeya ee soo dhaweynta. Sifooyinka "Furosemide" ee dambe, waayo, aad buu u kordhiyaa xaddiga kaadida ee labada saacadood ee ugu horeeya la daciifaan tartiib tartiib ah ee wax soo saarka kaadida.

Sidaas darteed, bukaanka shaqada la hypertension ahaan ama kelyaha chronic ama wareegga dhiigga macquul codsan "Torasemide" edbinta (ay qiimaha kor ku xusan) on codsiga taas oo ka kooban macluumaad ku saabsan xoojinta weyn ee diuresis in markii ugu horeysay ee soo dhaweynta. Si kastaba ha ahaatee, da'da hawlgabka ee dadka bukaanka ah ee ka maqan of baahida loo qabo in si yimaado oo shuqulka, xawaaraha saarka kaadida waa ku dhawaad ku tacaluqda. Waxa aanu la abuuro dhibaatooyin, oo sidaas daraaddeed kuu ogolaanaya in aad si aad u hesho analoogga ah fasalka cheap - "Furosemide".