Zoledronic acid: saamayn pharmacological iyo analogues

Waxaa la og yahay in bisphosphonates u muuqdaan in ay la xakameeyo horumarinta metastasis lafaha iyo ka hortagga lafo beesho. Mid ka mid ah daroogada fiican ka tirsan group this - zoledronic acid. Sidoo kale, waxaa jira cadaymo muujinaya in daroogada this leeyahay Iscelin angioneogenesis, duulaankii buro, Amda unugyada burada in nudaha lafaha, xaadiriyaan apoptosis, oo waxaa jira iskaashi la chemotherapy.

Dejinteedu 1 Vial

laktosmonohydrat acid Zoledronic - 4.26 mg Excipients - sitraydh Sodium, D-mannitol.

Farmashiiste

inhibitor An of resorption lafaha. Zoledronic acid iska leh fasalka cusub oo heer sare ah bisphosphonates. Waxay saamayn ah ee doorashada lafaha. Yaraynaysaa waxqabad ee osteoclasts, iyadoon dhibaato saamayn xun ku formation iyo tayada kale ee unugyada lafuhu. Saamaynta bisphosphonates on lafta ku salaysan yahay isku mid ah sare si ay lafta mineralized, laakiin hab saxda ah ee u taagoo in bixisaa anada waxqabad ee osteoclasts, ilaa maantadan la joogo weli aan la bartay. Sidoo kale waxa uu leeyahay a guryaha anti-buro toos ah, hubinta tayada shaqo ee metastasis lafaha.

Giisa ogaaday in zoledronic acid, xaadiriyaan apoptosis iyo badashada anada unugyada saamayn antitumor ah si toos ah on myeloma, iyo sidoo kale on unugyada kansarka naaska, halka yareeyo halista metastasis. Sidoo kale, zoledronic acid uu leeyahay hantida a of yaraynta fiirsashada calcium in hypercalcemia serum, kaas oo sababa buro ah.

Tilmaamayaasha

• lesions Osteolytic ee Axdigu myeloma.
• Osteoblastic, osteolytic metastasis lafta isku dhafan ee burooyin waaweyn.
• Hypercalcemia, kaas oo sababa kansar.

sababo

• Uurka iyo naas-nuujinta.
• kaafi kelyaha.
• Carruurta iyo dhallinyarada (amniga arjigaaga aan loo aasaasay).
• Diidmo in bisphosphonates iyo zoledronic acid.
• Taxadarka: cillad kelyaha, neefta bronki, failure cagaarshowga.

waxyeellooyin

Dhiig, Torombositobiiniya, madax-xanuun, wareer, conjunctivitis, lalabo, anorexia, matag, shuban, xanuun lafaha, arthralgia, hypophosphatemia, hypocalcemia, qandho, flu syndrome, daal, miisaanka oo kordha. In daaweynta bukaannada qaba zoledronic acid waxaa mararka qaarkood lagu arkay horumarinta osteonecrosis daanka (sida caadiga ah ka dib markii qalliin ilkaha).

Qadarka Qaadashada

faleebo xididka, iyo 15 daqiiqo, laakiin aan ka yarayn gudahood. Metastases of myeloma dose of 4 mg talinayaa bishiiba hal mar. Marka hypercalcemia, kaas oo sababa buro malignant, qiyaas ah 4 mg mar maalin kasta.

ganaaxyada

Marka daroogada ay maamusho, waxaa lagama maarmaan ah in la xakameeyo fiirsashada of magnesium, fosfooraska, kariyaatiniin iyo calcium ee serum dhiigga. Haddii ay suurtagal tahay, waxaa lagu talinayaa in ay ka fogaadaan qalliin ilkaha.

Zoledronic acid. analogs

Daroogooyinka "Actonel", "Aneldronat", "Areda lyophilisate", "Bonviva", "Bondronat", "Bonefos", "Klobir", "ksidifon", "Lindron", "Ostalon", "Ostealen", "Osterepar" "Pamidronate", "Pomegara", "Rizendros", "Strongos", "Tevanat", "Foroza" "Fosamax", "Fosfoteh", "Rizarteva".

Zoledronic acid. qiimaha

Sida caadiga ah, goobaha ku lug qaybinta daawooyinka sharciga ah, ayaa tilmaamaya qiimaha alaabtooda. Laakiin, qaab daran oo ku filan, qiimaha zoledronic acid waxaa badanaa lagu tilmaamay qiyaastii. Laakiin qiyaasi miraheeda gaadho ku saabsan 14 kun rubles per dhalada. Iibiyaa farmasiyada by qoro oo keliya.

Macluumaadka kor ku xusani waxaa loogu tala galay in ay bartaan shaqaalaha caafimaadka. Maqaalkani waxa uu ku saabsan yahay zoledronic acid ma beddelo talo aqoon ah dhakhtar, oo aan ku siin karaan ballanqaadka ah ee saamayn togan ka isticmaalka daroogada.