Ansixin kariyaatiniin

In daawada casriga ah, ereyga "ansixin", taas oo ka dhigan nadiifah taranta tilmaame xawaare dareere noolaha qaarkood. Isticmaalka tilmaame this ayaa si weyn u weynayn fahamka pharmacokinetics iyo pharmacodynamics oo ka mid ah iyo waxyaabaha kale ee our.

Sidaas darteed, tusaale ahaan, ansixin kariyaatiniin waxaa lagu go'aamiyaa iyadoo la isticmaalayo baaritaano lagu ogaanayo Reberga-Toreeva. Waxaa xusid mudan in haddii ay taasi ay macquul tahay in lagu ogaado heerka sifeynta sida maalkii endogenously dhexsameeysmo jirka iyo bixisey ka baxsan (daawooyinka iyo siyaabo kale). Qiimaysay waxaa la sameeyaa by xisaabinta shaandhaynta xooga (glomeruli) ee heerka sii daayo plasma ka walax gaar ah. account waxaa lagu qabtay waqti go'an (inta badan - maalin).

Isagoo ka hadlayay kariyaatiniin, waa in fiiro gaar ah u xaqiiqda ah in ay ka saareen jidhka ka yahay inta badan ay sabab u tahay waxqabad sifeynta kelyaha dareenka. Iyada oo ku saleysan this, sida heerka ansixin kariyaatiniin noqon lahaa muhiim ah in qiimaynta of kelyaha shaqaynaya sifeynta glomerular. Waa in la ogaadaa in tiradaasi waxa lagu gartaa ma aha oo kaliya awooda shaqo ee nidaamka filter ah, laakiin sidoo kale qaar ka mid ah carqalad kale ee xubnaha aadanaha iyo nidaamyo. Wax kabadal, midhona kor ansixin kariyaatiniin oo noqon karaan wax caddaynaya ee socodka dhiigga ku filneyn in kelyaha (atherosclerosis, iyo af ba'an iyo horumarinta - thromboembolism).

Heerka hoos u dhaca dhaqdhaqaaqa kelyaha dhacdaa ka dib intii afartan sannadood ah. Yaraynta heerka sifeynta glomerular of 1% sanadkiiba. Ka dib lixdan sannadood, heerka waxqabad wax yar ka dhaqso hoos u dhacay (isbedeladan ugu horrayn waxay ku xiran yihiin gabowga ah ee u shaqeeyo). Si kastaba ha ahaatee, waa in la ogaadaa in mid ka mid ah daliilka Isbadal noocan oo kale ah aan arkay sabab ah in dadka waayeelka ah waa la gaabis oo dhan geeddi socodka dheefshiidka, oo ay ku jiraan ereygu wuxuu ahaa ee kariyaatiniin qoomiyadda.

Marka diyaarinta tijaabada Rehberg loo baahan yahay in laga saaro isticmaalka daawooyinka qaarkood saamayn ku yeelan kara kooraska daraasadda (daawooyinka "Cortisol" "Furosemide", "Corticotropin", "Methylprednisolone," "tyroksiini" iyo kuwo kale).

Si aad u dhigay muunad ah sampling kaadida waxaa la sameeyaa, iyo sidoo kale baaritaan dhiig oo ku saabsan heerka celceliska kariyaatiniin plasma.

Ka mid ah tilmaamo ku ujeedo waxbarasho ah: cudurada hormoonada jidhka, qiimaynta waxqabadka functional kelyaha, iyo sidoo kale qiimeynta saameynta dhaqdhaqaaqa jirka.

Iyada oo ku xidhan heerka hoos u ansixin u qeexaan ama kale xadgudubyada.

• 30 ml / min / m2 oo ah 1.7 - hoos u dhac ku shaqo kelyaha ee dhexdhexaad ah;
• 30-15 ml / min / m2 1.7 - joogitaanka of kelyaha (ama degree subcompensated magdhow);
• <15 ml / min / m2 1.7 - wajiga decompensation renal failure.

Waxaa muhiim ah in la fahmo in awooda shaqo ee nidaamka sifeynta ay go'aamiso ansixin kelyaha ee kariyaatiniin, heerka kuwaas oo intii lagu jiray tijaabada Reberga muujinaysaa kelyaha caadi ah.

Si kastaba ha ahaatee, qaar ka mid ah cudurada mana keenaan isbedel ah tilmaanta (tus, baylonfiritis chronic).

Heerka kariyaatiniin ee dhiigga ku xiran tahay waxqabad ee ay Avv qoomiyadda iyo ay heerka of Digo kaadida. Waxaa muhiim ah in la fahmo in tiradaasi aanay ku xiran tahay oo kaliya on waxqabadka nidaamka shaandhaynta, laakiin sidoo kale xawaaraha iyo mugga nuugay walxaha in formation of kaadida hoose.

Sidaas darteed, hadda Reberga muunad (go'aaminta ansixin kariyaatiniin ah) ku filan si aad u hesho isticmaalka baahsan ee dawada lagu ogaanayo. Xiriirka A toos ah u dhexeeya shaqada ansixin iyo kelyaha siinaya hab sare muhiimadda ogaanayo.