"Azathioprine": analogues, qiimaha, guide iyo dib u eegis

cudurla - Koox ka mid ah xaaladaha bahal ah taas oo ay jirto waxaa kordhay dhaqdhaqaaqa of habka difaaca ka dhanka ah jidhkiisa. In si loo yareeyo jawaabta difaaca jirka, daroogada qoray cabudhinayo habka difaaca jirka. Kooxdaan daroogada waa lagama maarmaan in xubin badalida si looga hortago in diidmada jab. Bal aynu eegno daroogada noocan oo kale ah, sida a "azathioprine" analogs of daroogada, iyo tilmaamaha isticmaalka qaababka ay.

soocista pharmacological

In uu qayb ka mid ah "azathioprine" daroogada waxaa ku jira qayb firfircoon ee isku magaca. xarunta kiimikada Tani waa derivative ka mid ah walxaha lagama maarmaanka u ah ereygu wuxuu ahaa ee DNA iyo RNA. In jidhka, azathioprine siinayaa Avv DNA iyo, sidaas awgeed, uu hakiyo geedi socodka qaybsamidda unugga ee unugyada. Yaraynta waxqabadka nidaamka difaaca jirka oo uu keeno saameynta ay daroogada "azathioprine" ee nudaha lymphoid.

Sidaas awgeed waxaa laga Iscelin of hababka kala qeybinta unug iyo wax ka qabashada difaaca gacanta. Ka dib markii hordhaca ah ee "azathioprine" diyaarinta ee jidhku waa hoos u dhac aan caadi ahayn in tirada phagocytes iyo hoos u ereygu immunoglobulin. Ha noo sii falanqaynta macluumaadka: maxay yihiin sifooyinka ah "azathioprine" analogues daroogada, qiimaha, tilmaamaha loo isticmaalo.

Pharmacokinetics

Daawada waxaa aad si fiican u nuugo galay wareegga systemic, iyo fiirsashada ugu badnaan arkay 2 kaliya saacadood ka dib markii maamulka afka ka dib. daroogada ma aha gaar ahaan danbeeyaan borotiinka plasma: ay ku qabanaya iyaga ilaa 30%. Wixii saamayn sifo dheefshiidka hoose azathioprine ama pass ugu horeysay iyada oo beerka.

Isagoo maraya hepatocytes ah, daroogada la metabolized xarunta firfircoon - mercaptopurine, iyo taas oo uu leeyahay saamayn pharmacodynamic. Dejinteedu ku dhowaad si buuxda u raaca la bile. kaadida soo raaca by aan ka badnayn 2% medicament.

Tilmaamayaasha

Diyaarinta analogues "azathioprine" la walax isku mid ah oo firfircoon ayaa la tilmaamay in loo isticmaalo in xubin badalida si looga hortago fal-celin diidmada jab.

Sidoo kale, daroogada waxaa ku ool ah loo isticmaalo si dhab ah rheumatological in lagu daweeyo rheumatoid arthritis iyo shalalka sida hepatitis, lupus erythematosus oo nidaamsan, psoriasis, purpura thrombocytopenic, pemphigus, iyo kuwo kale oo badan.

sababo

Drug "azathioprine" waa u bukaanka qaba diidmo qayb daroogada. Sababo la xaqiiqada ah in daawada uu hakiyo oo dhan jeermiska dhiigga, "azathioprine" waa u ee cudurada dhiigga (leykotsito- anemia iyo lymphopenia, Torombositobiiniya), iyo sidoo kale uurka leh iyo xanaanada.

Isticmaal inta aad uurka leedahay iyo naas-nuujinta

walaxda firfircoon galaa caanaha naaska iyo iyada oo caqabad gematoplatsentarny. Marka tan la eego, isticmaalka laguma talinayo in uur leh iyo naas-nuujinta. Haddii loo baahdo, balan ah ee daroogada ama analogues ay in this category ka mid ah dadka loo baahan yahay si ay u qiimeeyaan khatarta ka imanaysa isticmaalka isticmaalka daroogada iyo waxyeelada ka iman kara in hooyada iyo ilmaha caloosha ku. Marka uu u xilsaarayo wakiilada inta lagu jiro naas-nuujinta dhawaan si aad u joojiso.

Features of codsiga

The daroogada iyo analogs ay u baahan tahay in loo isticmaalo si taxadir leh ee bukaanka ka cabanaya hablo, iyo in bukaanka qaba deficiency of oxidase xanthine.

waxyeellooyin

kooxda ugu weyn ee dhibaatooyinka soo raaca ee la xidhiidha Iscelin of shaqo dhuuxa lafta, masuul ka ah wax soo saarka ee unugyada dhiigga cas. In codsanaya analogs kooban azathioprine, in la kordhiyo tirada unugyada dhiigga, yareynta count leucocyte, dhiig xinjirowga, anemia.

Waayo, qayb ka mid ah marinka dheef shiidka dhibaatooyinka ugu badan waxaa ka mid ah: hoos rabitaanka cuntada, xanuunada saxarada, function cagaarshowga oo yaraada, lesions kolit of mareenka caloosha iyo mindhicirka. khasaare suurtogalka ah ee hepatocytes, raaceen by kordhiyo bilirubin ama baaritaano kale beerka. In bukaan qaliin loogu talagalay xubnaha iyo unugyada waxa dhici karta in ganaca, lesions kolit ee caloosha, mindhicirrada, horumarinta hepatitis sun.

cadaanyo dhacaan aad u dhif ah marka ay maamusho daroogada analogs "azathioprine" ku salaysan waxa on (tus, "azathioprine"). Eebbe ma muujiyay, inta badan sabab u ah finan maqaarka ama dalalka xumad.

Ka mid ah waxyeelo kale waa in la ogaadaa horumarinta geedi socodka faafa sare ee jirka, muuqaalka kore ee xanuun dhanka muruqa ah oo si wadajir ah, yaridu functional kelyaha ba'an. Xaaladaha daran qaar ka mid ah, daroogada analogues "azathioprine" la walax isku mid ah oo firfircoon waxay keeni kartaa dhiig yari hemolytic, siinta calaamadaha ka habka dhexe ee neerfayaasha. Azathioprine sida pharmaceutically walax firfircoon ah, qayb ka mid ah daroogada magac isku mid ah iyo analogues ay, uu saamayn fahmayaan on uurjiifka (saamaynta teratogenic iyo mutagenic) oo awood u xanaajin muuqaalka kore ee geedi socodka buro iyo kansar ku xiga. Sidaas darteed, waxaa lagama maarmaan ah in la baaro magacaabidda daroogada "azathioprine" (kiniiniyo) ah ayaa eegaya, sharaxaada, analogues daroogada iyo dooran xeeladaha midig. Raadinta ka hor, waxaan la soco in sida azathioprine ka qayb firfircoon fulyo faa'iido on koorsada cudurka, sida ay ku muujinaya. Tan waxaa lagu tilmaamay dhakhaatiirta ma aha oo kaliya, laakiin sidoo kale isu bukaanka.

"Azathioprine" - micne ah, analogs

Azathioprine - gaar ah in ay hab gaar ah walax isagoo ficil jirka. In view of suuqa dawooyinka ee ma aha mid aad diyaarinta si fiican wakiil ka kooban azathioprine. Analogs "azathioprine" loo soo bandhigi karaa daroogada noocan oo kale ah, sida a "azathioprine".

daroogada waxaa laga heli karaa kiniin la azathioprine content la mid ah. midka kaliya ee waa kharashka "azathioprine" daroogada, kaas oo awoodo in 4-5 jeer kharashka "azathioprine" wax soo saarka Ruush.

Sunta iyo badinta

badinta daroogada "azathioprine" iyo dhiggiisa "azathioprine" muujiyey cudurada of mareenka caloosha iyo mindhicirka, xakamaynta of function dhuuxa lafta, iyo sidoo kale kor u kacay baaritaano beerka. daaweynta lagu sumoobo, sida daroogada laftiisa iyo analogues ay waa astaamaha, loogu talagalay in lagu reebay degdegga ah ee daroogada jidhka ka. No daawo gaar ah. Hababka naanin Dialysis waa wax ku ool ah oo qayb ka sababtoo ah walaxda firfircoon iyaga si buuxda ma raaca.

ganaaxyada

The daroogada iyo analogs ay lama talinayo in la isticmaalo muddada-dheer. Bilowga ee daawaynta ay u baahan tahay la socodka joogtada ah ee unugyada dhiigga durugsan, iyo sidoo kale la socodka falgalka beerka.

In mustaqbalka, ay gacanta maalin fasaxa, qabashada waxbarashada socodka bishiiba hal mar ama laba jeer.

gunaanad

The daroogada iyo analogs ay u xil karaa oo keliya ku takhasusay khibrad leh. Ka hor inta aysan hab loo baahan yahay in baaritaan buuxa oo suurto gal ah u qabtaan therapy dayactirka. Wixii macluumaad dheeraad ah, u saamaxaaya magacaabidda "azathioprine" tilmaamaha diyaarinta loogu isticmaalo. Price, analogues qalab this oo qayb ka ah la ruxruxo ahaan dadka bukaanka ah. Sidaas darteed, qiimaha ugu yar ee 50 kiniiniyada waa in meesha of 250-300 rubles, oo ku saabsan analogues kor ku xusan. Ka hor inta qaadashada waa in aad miisaantaan ah "pros" iyo "khasaaraha" oo uu bilaabo daaweynta.