Beta-blockers: liiska daawooyinka, calaamado muujinaya in loo isticmaalo

Daawooyinka la saamaynta ku daweynta weyn hubkaas ayaa loo isticmaalaa by takhasus. Waxay waxaa loo isticmaalaa daawaynta cudurada wadnaha, taas oo ah kuwa ugu dhex heley kale soo noqnoqda. Cuduradan waxay u badan tahay in ay keento dhimasho bukaanka. Daawooyinka waxaa loo baahan yahay in ay daaweeyaan cudurada kuwaas, waa beta-blockers. List fasalka daroogada, oo ka kooban 4 qaybood, oo ay kala soocidda hoos lagu soo bandhigay.

Qoondaynta oo ah beta-blockers

Qaab dhismeedka kiimikada ah ee fasalka daroogada non-uniform iyo saamaynta caafimaad madaxbannaan yihiin. Wax badan ayaa muhiim ah in la qoondeeyo gaar ah si receptor gaar ah iyo xidhiidh buuna isaga for. The sare cayimayo ee beta-1 receptors, dhibaatooyinka yar ee daroogada. Marka tan la eego, liiska daawooyinka beta-xanibaha soo bandhigay sida qumman.

Jiilkii ugu horeeyay ee wax soo saarka:

• non-xushay beta-receptor 1 iyo nooc 2, "Propranolol" iyo "Sotalol", "timolol" iyo "oxprenolol", "nadolol," "Penbutamol".

Jiilkii labaad:

• beta xushay receptor type 1, "bisoprolol" iyo "Metoprolol", "acebutolol" iyo "Atenolol", "Esmolol."

qarnigooda saddexaad:

• beta ee Doorashada 1 blockers leh guryaha pharmacological dheeraad ah: "Nebivolol" iyo "Betaksalol", "talinolol" iyo "celiprolol".
• Nelektivnye beta-1 iyo beta-blockers 2 la guryaha pharmacological dheeraad ah: "Carvedilol" iyo "carteolol," "Labetalol" iyo "bucindolol".

Kuwani beta-blockers (eeg liiska daawooyinka. Kor) waqtiyo kala duwan ay ahaayeen kooxda ugu weyn ee daroogada loo isticmaalay iyo waxa ay hadda loo isticmaalo cudurada marinnada dhiigga iyo wadnaha. Qaar badan oo iyaga ka mid ah, inta badan wakiillo ka ab ka labaad iyo saddexaad, waxaa loo isticmaalaa maanta. Sababo la xiriira saamaynta ay pharmacological maareeyo si loo xakameeyo garaaca wadnaha oo haysta laxanka ectopic in intraventricular ah, si loo yareeyo inta jeer ee weeraro angina ah angina.

Key soocidda

The daroogada horrayn waa xubno ka mid ah jiilka ugu horeeyay, taas oo ah, non-xushay beta-blockers. Liiska daawooyinka iyo diyaarinta waxaa sare lagaa siin. Daawooyinkan waxaa awood u hortaagaan receptors oo ka mid ah 1-dii iyo nooca 2aad, siinta labada saamaynta ku daweynta iyo kooxdiisa, taas oo lagu qeexay bronchospasm. Maxaa yeelay, iyagu yihiin in bukaanka qaba COPD, neefta bronki. Ugu muhiimsan ee ka mid ah daawooyinka jiilka kowaad waa "Propranolol", "Sotalol", "timolol".

Waxaa ka mid ah wakiilo ka jiilka labaad ee liiska daawooyinka beta-blockers, hab ay of action ah oo la xidhiidha aasaasiga ah hortaagaan receptors nooca ugu horeysay. Waxay waxaa lagu gartaa buuna daciif ah nooca receptor 2, maxaa yeelay, marar dhif ah keeni bronchospasm in bukaanka qaba neef iyo COPD. Diyaargarowga ugu muhiimsan ee jiilka 2aad yihiin "bisoprolol" iyo "Metoprolol", "Atenolol".

Jiilkii saddexaad ee beta-blockers

Wakiilada qarnigii saddexaad - waa blockers beta ugu dambeeyay. Liiska daawooyinka ka mid ah "Nebivolol", "carvedilol", "Labetalol", "bucindolol", "celiprolol" iyo kuwa kale (eeg. Kor). Ugu muhiimsan ee ka soo dhibic caafimaad ee view yihiin kuwa soo socda: "Nebivolol" iyo "Carvedilol". Asal advantageously hor istaagay beta-1 receptors iyo dareen la sii daayo NO. Tani waxaa sababa ballaarinta marinnada dhiigga iyo in la yareeyo halista ah ee dabar atherosclerotic.

Waxaa la rumeysan yahay in beta-blockers - daawooyinka loo isticmaalo hypertension iyo cudurka wadnaha, halka "Nebivolol" - daroogada generic in uu yahay haboon labada ujeedo. Si kastaba ha ahaatee, ay kharashka waa wax yar ka sarreeya qiimihii kuwa kale. Similar in guryaha laakiin wax yar ka qaalisan, waa "Carvedilol". Waxay isku daraa ee guryaha ka mid ah beta-1 iyo Alfa-xanibaha caawiya si loo yareeyo inta jeer iyo ciidanka ee foosha wadnaha, iyo sidoo kale in ay ballaariso maqnaadaan, oo weelasha oo.

saamaynta waxay u ogolaadaan inaad si loo xakameeyo chronic wadnaha iyo dhiig-karka. Iyo in ay dhacdo wadnaha, "Carvedilol" - daroogada ah ee doorashada, maxaa yeelay, weli waa poesie ah. Sababtoo ah qalab ka hortagtaa xaalad xumeyd ee dabar atherosclerotic.

Kooxda daroogada Tilmaamayaasha

All muujinaya isticmaalka beta-blockers waxay ku xiran tahay sifooyinka gaarka ah ee group gaar ah daroogada. In blockers aan la xushay tilmaamo waa cidhiidhi, halka la xushay ammaan iyo si ka sii ballaaran oo lagu dabaqi karo. Guud ahaan, tilmaamo waa wax caadi ah, in kasta oo ay xadiday adagtahay ee isticmaalka daroogada ee bukaanada qaar ka mid ah. Waayo, daawooyinka aan la xushay socda tilmaamo:

• Wadnaxanuun myocardial oo dhan muddo, angina, nasasho, angina deganayn ,
• Wadne normoforma iyo tahiforma;
• tachyarrhythmia sanka la waday on leh ama aan lahayn isaga intraventricular;
• wadnaha (chronic);
• hypertension ,
• tayroodh, tayroodh, leh ama aan lahayn dhibaatada waxaa ka mid ah;
• pheochromocytoma ka xiisadda ka mid ah therapy aasaasiga ah ama cudur preoperatively;
• xanuunka dhanjafka,
• Dissecting aneurysm aortic;
• daroogada ama khamriga syndrome.

Sababo la xiriira ammaanka kooxo badan oo ka mid ah daroogada, gaar ahaan jiilka labaad iyo saddexaad, liiska daawooyinka beta-blockers, inta badan u muuqataa in diiwaanka daaweynta wadnaha iyo cudurrada vascular. Sida laga soo xigtay inta jeer ee codsiga, waxay ku dhow yihiin isku leh celiyeyaasha ACE, kuwaas oo loo isticmaalo daweynta of wadnaha iyo dhiig-karka la dheefshiidka syndrome iyo waxa iyada oo aan. Wada jir ah ula diuretics, labadan kooxood ee daroogada awoodaan in ay kor u cimri in failure wadnaha chronic.

sababo

Beta-blockers, iyo sidoo kale daawooyinka kale, waxay leeyihiin sababo qaar ka mid ah. Iyo sababta oo ah daroogo u dhaqmaan on receptors, waxay ammaan badan celiyeyaasha ACE yihiin. sababo Guud:

• neefta, COPD;
• bradyarrhythmia, sanka buka syndrome,
• block atrioventricular II degree,
• hypotension astaamaha;
• uurka, ilmahaaga;
• decompensated wadnaha - wadnaha oo shaqadiisa gaba II B-III.

Sidoo kale u dhaqmo sida cadaanyo contra xasaasiyad jawaab u aqbaliddoodii xanibaha. Haddii xasaasiyad daroogo kasta uu yeesho, daroogada bedelka si kale u furfuraya dhibaatada.

Saamaynta isticmaalka caafimaad ee daroogada

Marka daroogada angina yareyn inta jeer weeraro angina iyo xooggooda, loo yareeyo suurtagalnimada dhacdooyinka coronary ba'an. In daaweynta CHF la beta-blockers la celiyeyaasha ACE iyo diuretics laba korodhka Filashada nolosha. Daawooyinka waxa ay yihiin wax ku ool ah tachyarrhythmias xakamaynta iyo dulmin garaaca ectopic soo noqnoqda ee ventricle ah. Guud ahaan, lacagaha si ay u caawiyaan xakameeyo astaamaha mid ka mid ah cudurka wadnaha.

Gabagabadii ku saabsan beta-blockers

"Carvedilol" iyo "Nebivolol" - waa beta-blockers ugu fiican. Liiska daawooyinka ay muujiyaan waxqabad ahaaneed ee beta-receptors, dhameystirta liiska dawooyinka ugu weyn ee daaweeyn muhiim ah. Maxaa yeelay, in bukaan eegida waa in la isticmaalaa ama qarnigii saddexaad, kuwaas oo "Carvedilol" ama "Nebivolol" ama inta badan la xushay ee beta-1 daroogada receptor, "bisoprolol", "metoprolol". Xataa maanta, codsigooda kuu ogolaanayaa inaad si loo xakameeyo hypertension iyo in lagu daaweeyo cudurrada wadnaha.