"Capecitabine": tilmaamaha loo isticmaalo, dhigooda dhabta ah, foomka sii daayo, soo saaraha. "Capecitabine-TL": war

Capecitabine (. Latin Capecitabinum) - walax waa derivative a carbamate fluoropyrimidine. Waxaa iska leh kooxda ee antimetabolites - xeryahooda gaar ah ay awoodaan in ay la xakameeyo koritaanka of burooyinka halista ah. Xiisaha in walxaha sida asalkiisu ka soo jeedo ee 1960 g. natiijo wanaagsan oo kuwii hore ka helay waxbarashada ee jiirka. markii qaar ka mid ah ka dib, waxaa la ogaadey in ay ku oolnimada in daawaynta cudurada kansarka qaarkood in aadanuhu.

Maanta, dawooyin badan oo ay ku jiraan anticancer capecitabine walaxda firfircoon. Reviews bukaannada badan yidhaahdo oo ku saabsan guusha codsiga ah ee qalabka sida ee therapy anticancer.

Daaweynta iyo hantida

Formula capecitabine - 5'-deoxy-5-fluoro-N - [(pentyloxy) carbonyl] cytidine. Kooxda kiimikada Antimetabolites ka wakiil yahay tiro ka mid ah walxaha ku jira la mid ah ee dabiiciga ah si ay wax soo saarka shiid (Dheef) aadanaha. Waxay awoodi karaan inay galaan reactions dheefshiidka, iyo inay la qabsadaan hoos u dhigi qaar ka mid ah geedi socodka lagmamaarmaanna u yihiin. Haddaba waxaa jira cillad ah in unugyada burada muhiim ah iyo is-celin ka mid ah koritaanka marka la isticmaalayo diyaarinta ku salaysan capecitabine walax. Reviews dadka ka hadleynaa yareeyo size of burooyinka. Tani qaab hawleed waxaa lagu magacaabaa cytostatic.

guryaha waxay u ogolaadaan isticmaalka walxaha iyaga antimetabolitnyh in therapy anticancer. ay oggolyahay xaqiijiyay ka dhanka ah burooyinka halista ah ee mareenka caloosha iyo mindhicirka iyo qanjiro caanaha. Xaaladdan oo kale, natiijo fiican ku siinayaa labadaba monotherapy iyo isku darka la wakiilada kale. Si aad u taariikhda, ku salaysan anti-metabolites abuuray in ka badan 800 oo alaabta, laakiin weli sii wadaan in ay raadiso kooxaha cusub ee xeryahooda.

hab of action

Capecitabine shaqeyn dhacdaa unugyada burada, ka dib markii taas oo uu bilaabo inuu ku isticmaali saamaynteeda sun on unugyada (hab cytotoxic). walax Tan waxaa ku lug-shiid ee falcelinta iyo keenaysaa in xaqiiqda ah in ay caafimaad iyo unugyada burada ayaa la beddelay analogs cytotoxic. Haddaba waxaa jira walax dhalin xadgudub lagama maarmaanka u ah Avv DNA iyo, sidaas awgeed, habka qaybinta.

Tan iyo unugyada u joojiyaan in la kordhiyo tirada ay. In seenyo kale, waxaa jira a "bedelay" mid walax kale, ku dheehan Avv borotiinka waa wareersan marka la qaadanayo daawooyin ku salaysan xarunta capecitabine. Guide qeexayaa si faahfaahsan geedi socodka this.

hab ay of this Isbadal yaraynaysaa suurtagalnimada ee waxyeellada in unugyada caafimaadka qaba. Capecitabine waa u xoog badan in burada laftiisa, ka badan in unugyada ku wareegsan. feature a noocan oo kale ah waa in ka yar waxyeelada jidhka marka qofka la daweeyey daroogada ku saleysan capecitabine walaxda. Tilmaamaha loogu isticmaalo ku talinaysaa in la helo maal-qaadasho adag lagu qeexay in ay yihiin goostay uu dhakhtarka xaadirka ah.

Joog walax ee jirka

Marka la helo capecitabine waa ay nuugista degdeg ah ee mareenka caloosha iyo mindhicirka. Haddii aad cuni waqtigan, geedi socodka hoos u dhigi doono. Sidaa darteed, ku saleysan daroogada antimetabolite soo dhoweynta waa la fuliyay ka dib markii uu qofku cuno. Isbadal dheeraad ah dhacdaa in walax beerka, xaddi gaar ah oo capecitabine iyo metabolites ay ku xidhaan in borotiinada (tus, albumin). The heerka serum peak gaadhin kadib markii 1.5 -3 saacadood ka dib codsiga daroogada. Waxa uu ka hadlayaa in ay daroogada "Capecitabine" edbinta. Analogs leeyihiin pharmacokinetics la mid ah.

Inta badan oo ah walaxda waa raaca kaadida, hoose - saxarada ah. Waxaa intaa dheer, ma aha oo kaliya ka baxo capecitabine jidhka beddelin (3%), laakiin taagayo ay. Qaar ka mid ah iyaga ka mid ah waxaa metabolized in ay xeryahooda firfircoon ka yar. The joogitaanka iyo isbedelka of capecitabine ee jirka ku jira oo aan la saameeyeen jinsiga, da'da, jinsiyadda.

Marka ay maamusho?

Capecitabine galay daawooyinka kala duwan ee ay maamusho in bukaanka qaba kansarka naasaha, oo ay ku jiraan marxalad xadka-. Xaaladdan oo kale, waxyaabaha la isticmaalay qaabka keliya, ama marka la isku daro daawaynta sababo ama la'aanta oggolyahay ee chemotherapy. Inta badan, capecitabine weheliso docetaxel.

Waxaa sidoo kale qoray in bukaanka qaba kansarka mindhicirka, hunguriga, caloosha, xameetida, ee kansarka mindhicirka, labadaba faafinta hoose ee masraxa, iyo inta lagu jiro metastasis. In daaweynta kansarka mindhicirka waxaa sidoo kale loo qoondeeyey "capecitabine". Tilmaamaha loogu isticmaalo si taxadir leh u raac qiyaasta lagula taliyey iyo hoggaansamaan talo ah ee dhakhtarka xaadirka ah.

Dhexgalka daroogooyinka kale

Haddii chemotherapy cadaato natiijo la'aan, ku takhasusay cudurka kansarka ah kuu qori karaa daaweynta isku dhafan, taas oo loo isticmaali doono "capecitabine". Tilmaamaha loogu isticmaalo wuxuu bixiyaa liiska khayraadka, taas oo ay suurogal tahay in si guul ah isku daraan.

Tusaale ahaan, la "docetaxel" - daroogada cytotoxic nooca tallaabo isagoo asal qudaar ah. Waa inay awoodaan inay ku adkaystaan muddo dheer in unugyada ku uruureen sare. Si kastaba ha ahaatee, isku-dar ah wakiilada sida waa u siiyo dadka qaba tirada platelets iyo neutrophils 100,000 / ul iyo 1500 / l, siday u kala horreeyaan. Sidoo kale "Docetaxel" ma khuseeyo dadka qaba dheeraad ah heerka of bilirubin. Xaaladdan oo kale, cawaaqibka xun ee suuragalka ah. Haddii "Docetaxel" sabab qaar ka mid ah "dayrta" ee daawada ah, sii therapy "capecitabine", laakiin at qiyaasood oo hoos.

Haddii ay dhacdo in daaweyn reactions diidmo "capecitabine" iyo "docetaxel" stop iyo baabi'iyo calaamadaha uu keeno. dheeri Scheme weheliso yeesho farsamada xirfad Oncologist. Qorshahani waxaa laga beddelo haddii ay dhacdo waxyeello sun.

"Capecitabine" aan la magacaabay waqti isku mid ah "Sorivudinom" - Wakiilka fayruska. isku darka Tani waxay kordhin kartaa sumoobo daroogada ugu horeysay. Isticmaalka isku daro daroogada antiepileptic "phenytoin" kordhiyaa-fiirsashada ee dambe ee plasma dhiigga. Waxa kale oo cudurka dhiig suurto gal ah in isticmaalka daawada xinjirowga lidka ku coumarin iyo hab, halkaas oo qayb ka ugu weyn - capecitabine. Tilmaamaha loogu isticmaalo digo ka dhalan kara, sidaas darteed waa in aad marka hore adigu baro la.

Yaa waa u?

Sababta in waa u, ama ku eg tahay daroogada waxaa laga yaabaa:

• dareen sarreeya (reaction elerji).
• Joogitaanka kaafi kelyaha ama cagaarshowga daran.
• marxaladaha kala duwan ee uurka (daroogada saamayn ku midhihii), marka laga reebo kiisaska nolosha hooyada waxaa la dhigay mudnaanta;
• Quudinta quudinta dhashay.

Sidoo kale hesho xadka capecitabine loogu talagalay dadka qaba cudurka wadnaha (CHD), marka xaalad ka mid ah fiirsashada korodhka bilirubin in, cudurka beerka xadka- dhiig si xadgudub ku ah hawlaha ay aasaasiga ah ee. diyaarinta ma waxaa lagu talinayaa in caruurta iyo dadka waayeelka ah. Tani waxa ay xaqiijinaysaa daroogada "Capecitabine" edbinta. Kurtumm hadli ku saabsan noocyo kala duwan oo waxyeelo iyo saamaynta sun ah ee daaweynta. Sidaa darteed, daaweynta capecitabine qaadataa meel iyada oo ay kormeerayaan adag Oncologist takhasus u leh.

Ma jiraan waxyeelo kasta?

Ka dib markii qaadashada daroogada noqon kartaa madax xanuun, state of daal, feejignaan xumo, daciifnimo. Hurdo la'aan laga yaabaa inuu dhaco, ama qeybsanaan - hurdo. Marar dhif ah - luma isuduwidda iyo dheelitirka, wareer.

Dhibaatooyinka ay keento on nidaamka wadnaha waa dhiig yarida (anemia). Ilaa xad yar u keeni kartaa angina, ischemia myocardial, stroke, wadne joogsi iyo kuwa kale. Haddii geedi socodka ka mid ah xubnaha neefsashada ay ku lug leeyihiin, waxaa jiri kara neefta oo ku qabata, dhuun xanuun, qufac. Aad ayay u yar - lungemboli, dubaaxin sambabada.

Marka loo isticmaalo in kooban oo keliya ama ay weheliso daaweyn ay suurtagal tahay saamaynta xun ee nidaamka muruqyada. Waxaa muuqato in xanuunka ee addimaha iyo dhexda, kac muruqyada hypertonus (myalgia), xanuun wadajir ah (arthralgia).

Maqaarka ayaa sidoo kale laga yaabaa in ay saameeyeen. waxay keeni kartaa dermatitis, erythema, qallayl-dhaafka ah ee maqaarka, guduudasho, cun cun, kabuubyo, hoolmay, cuncun, midabka jirka oo kordhay, dhaawaca uu saamayn ku ciddiyaha. Marar dhif ah, waxaa jira dildilaaca maqaarka, diidmo in shucaaca, hoolmay iyo dabacsanaan ka kordhay ee taarikada cidiyaha.

Waxaa ka mid ah dhacdooyinka kale ee loo kasin dhici kara geedi socodka faafa ay sabab u tahay hoos u difaaca jidhka uu. Ka dib markii therapy daroogada sababa hoos u dhac in platelets dhiigga iyo unugyada dhiiga cad. daliilka noocan oo kale ah wuxuu qeexayaa medicament "Capecitabine" diiwaanka a. Analogues siin saamaynta isku.

daroogada

"Capecitabine" ku haboon oo keliya in loo isticmaalo gudaha. Sida caadiga ah waxaa hoos waxaa lagu maydhay biyo ka dib markii nus saac cuntada ka dib, laakiin aan ka dambayn. Qiyaasta maalin walba waxaa lagu go'aamiyaa Oncologist ka dhigata, taas oo ku xiran of burooyinka, marxaladda horumarinta, iyo aagga guud ee dusha jirka. Waa suurad wacan in khabiirku uu horey u lahaa xirfadaha si ay ula daroogada this shaqeeyaan. Inta badan la qoray laba jeer-maalin - aroor iyo galabba. Xaaladdan oo kale, dabcan oo dhan waxay qaadataa laba toddobaad, ka dibna - nasasho intii toddoba maalmood ah, waxaana ku xiga daweynta celis ah.

Waayo, bukaanka qaba la'aan kelyaha, ka qaadasho maalin kasta hoos. By yareynta tirada leukocytes (leucopenia) iyo neutrophils (neutropenia) ee dhiigga ku sii wado qaadashada daroogada. Sidaas talinaysaa hab ah "Capecitabine" diiwaanka. Micne ah ama analogues maamula at initiative ee dhakhtarka xaadirka ah.

sumoobo

Waxaa jira dhawr digrii, sida uu taas soo koraya waxyeello sun ah daroogada "capecitabine" ah (Tilmaamaha Isticmaalka). Reviews dad badan ayaa sheegaya in tani ay tahay geeddi-socodka u gaar ah.

Waxaa jira dhowr darajo sumoobo:

• 1 degree. Waxaa jira waxyeellooyin yar.
• 2 degree. shuban The daran (ilaa 4 jeer maalintii a) raacay by barar addinka, guduudasho, xanuun waxqabad, kor u kac wayn ee bilirubin. Marka marxaladdan, soo dhaweynta go'do capecitabine ilaa calaamadaha sumoobo of stage 1.
• 3 degree. Shuban kor u nooleeyaa in 9 jeer maalintii. Waxay dhacdaa nuugeynin (sprue). Marka ay tani ayaa lagu arkay maqaarka xoog hoolmay, casaan, finan iyo nabaro. Waxaa jira xanuun af jirka ah, hoos u qabadka. Bilirubin waxaa kordhay 3 jeer. Marka marxaladdan oo daaweyn ah la joojiyo, iyo muujinta sumoobo of 1 degree sii helo hab in dose hoose.
• 4 degree. shuban More soo noqnoqda - ilaa 10 jeer maalintii. Saxarada dhiig. Waxaa loo baahan yahay soo saarida daawooyin, Goldogob mareenka caloosha iyo mindhicirka. Haddii calaamadaha degree ah ee daaweynta waa in la joojiyo oo aan marnaba dib u bilaabay.

Waa maxay tallaabooyinka u baahan tahay si ay u dhawraan ammaanka?

koorsada daawada waa inay qaataan meel ka yar kormeer caafimaad dhow. takhasus leh waa in waqtiga lagu ogaado daliilka sun ah -. Haddii lallabo, shuban, iwm Marka la ogaado mid ah qaababka kuwan, daaweynta la beddelo. Haddii loo baahdo, la baabi'iyo calaamadaha, la yareeyo qiyaasta maalin kasta, ka dhigi nasasho. Daaweynta waa in lagu sii, haddii calaamadaha sumoobo ma ay khatar ku tahay nolosha.

Waayo, dadka ku takhasusay la-socoshada cudurada wadnaha waa in si gaar ah dhamaystiran. Xaaladdan oo kale, waxaad u baahan tahay waqti ay ku muujin Saameynta xun ee nidaamka wadnaha iyo wakhtiga uu sameeyo isuduwidda loo baahdo.

Khubarada ka fogaadaan isticmaalka walaxda ku dhaqanka carruurta. Saamayntii ay la isticmaalo oo aan la aasaasay ee carruurta. Haddii daawada la hoos geliyey in ay qof dumar ah oo ku jira da'da dhalmada, waa in ay kula taliyay on saamaynta capecitabine on uurjiifka. Inta lagu guda jiray therapy, waa in ay isticmaalaan uurka lagu kalsoonaan karo.

Diyaargaraw iyo analogues

Waxaa jira waxyaabaha dhowr ku saleysan capecitabine. In suuqa Ruush waxaa jira 7 magaca ganacsiga daroogada, soo saaray dhowr shirkadood oo gudaha iyo dibadda. Tusaale ahaan:

• "Capecitabine".
• "Capecitabine-TL".
• "Tutabin".
• "Xeloda".
• "Kabetsin".
• "Kapetsitover".
• "Kapametin FS".

Tan iyo aasaaskii hab oo dhan mid ka mid ah iyo qayb ka mid ah oo firfircoon - capecitabine, inaad iyaga bartid noqon doonaa midka ah. Sida caadiga ah waxaa muujinaysaa miis xisaabinta qiyaasta siiyo miisaanka jidhka iyo circuit daaweynta saxo marka calaamad u ah heerar kala duwan sumoobo.

Waxaa muhiim ah in la fahmo in waxa ugu horeeya ee waa in lala akhriyaa, markii uu magacaabay, tusaale ahaan, "Capecitabine TL" - edbinta. macluumaadka ku jira dhexdeeda ma ku haboon yahay qalab is-maamulka! Dhamaan xisaabaha la xidhiidha mudada dose iyo daaweynta, soo saarta dhakhtar - Oncologist la aqoon ku filan in arrintan. Is-maamulka wakiilada anticancer keeni karo dhib hagaajin karin jirka.

Ha ka fikiro si aynu qaar ka mid ah daawooyinka.

Description of diyaarinta

• "Capecitabine - TL" dhigaysa OOO Ruushka shirkadda "Technology ee daawooyinka." component muhiim ah - capecitabine. Tilmaamaha loogu isticmaalo, foomka la sii daayo oo xiiso in badan. Ka fiirso faahfaahinta. Tani kaniini, filim-dahaarka leh. content walax firfircoon - 150 ama 500 mg. qaybaha darran, cellulose, lactose, sodium croscarmellose, hypromellose, milmahayn magnesium. Mid ka mid ah xirmo waxaa laga yaabaa in 60 ama 120 kiniin, iyada oo ku xiran qiyaasta of daroogada "Capecitabine - TL". Tilmaamaha waa ku jira macluumaad faahfaahsan oo ku saabsan isticmaalka lacagaha.
• "Capecitabine" - saarka la qayb ka mid ah oo firfircoon. Uu sharaxaad ay la mid tahay hab kor ku xusan. foomka Release of daroogada "Capecitabine" - oo kiniin ah. Tilmaamaha loogu isticmaalo ayaa sidoo kale ku lifaaqan ee xirmadan.
• "Kabetsin" - Wakiilka anticancer ah soo saaridda Ruush ( "Company" Deco "). Product foomka - Kiniin dahaarka leh kula 150 ama 500 mg oo ah walaxda firfircoon. maaddooyinka Sare: cellulose mikrokristallin, crospovidone, istaarijka, ku milmahayn magnesium. Leave farmashiyaha oo keliya by qoro.
• "Kapetsitover" - wax soo saarka shirkadda Ruush OJSC "Veropharm". Wakiilka anticancer lagu helo loox oo 150 ama 500 mg 60 - 120 gogo '. capecitabine sokow, in diyaarinta ka mid ah lactose, cellulose, sodium croscarmellose, milmahayn sodium, iyo hypromellose.
• "Kapametin FS" - soo saaray shirkadda Ruush "Nativ" - qaybgale firfircoon barnaamijka of bedelay dejinta ee daroogada. "Kapametin FS" daayo qiyaasta ah 150 - Wakiilka firfircoon 500 mg - capecitabine. Tilmaamaha loogu isticmaalo (oo sidoo kale soo saare yeel waxa ku jira) ayaa kuu sheegi doona inta kiniin halkii pack - 60 ama 120.
• "Tutabin" - saarka shisheeye ku saleysan capecitabine. Waxay soo saartaa shirkad Argentine Laboratorio VARIFARMA SA, kaas oo sidoo kale wakiil u ah diiwaan. "Tutabin" waxaa la soo saaray qaab kiniin la content firfircoon of 500 mg. kartoon tilmaamaha bixisey - Baako.
• "Xeloda" - Wakiilka antitumor ah. Soo saaray in Switzerland by "by F. Hoffman La Roche" iyo kuwii shuraakada iyo xafiisyada wakiilka dalalka kale - Mexico iyo Maraykanka. In suuqa Ruush waxaa jira 5 daroogo magaca ganacsiga. foomka Product - kiniiniyada (150 - 500 mg) ee 60 ama 120 oo gogo '. in xirmo hal.

Reviews

Reviews shaqada ku saleysan noocyo kala duwan oo daroogo capecitabine. Intooda badan waa positive, laakiin waxaa jira dib u eegista xun. Si kastaba ha ahaatee, taasi ma sifaha lacagta sida xumaan iyo wanaag toona, maxaa yeelay, waa in aad had iyo jeer tixgeliyaan shaqsi ee jirka ka mid ah qof kasta. Helitaanka habka isku mid ah dad kala duwan marnaba siin natiijo isku mid ah. Of muhiimadda ugu weyn waa xaqiiqada ah kaas oo jidhka ka dhacay neoplasm iyo inta ay socotay.

Dadka qaatay daroogada, ayaa sheegay in a saamayn xoog sun ah dhowr maalmood ka dib markii gelitaanka. Si kastaba ha ahaatee, dad badan oo soo sheegaan horumar la taaban karo in xaaladooda iyo xataa galo dembidhaafka. xaalad muhiim ah in daawadu ay ka shaqeyn doonaan iyo sidoo kale suuragal ah in hal qof, Oncologist talinta iyo u hogaansanaanta adag tilmaamaha uu ku saabsan daaweynta.