"Celecoxib": tilmaamaha loo isticmaalo, dib u eegista. analogues daroogada

Daaweynta cudurada la xiriira dhaawac nidaamka muruqyada, dalabaadka suuqa dawooyinka la abuuro daroogo cusub oo waxyeelo ka yar iyo wax ku-oolnimada weyn. Seynisyahanno ku helay oo ku dhexsameeysmo jiil cusub oo non-steroidal anti-bararka ku saleysan celecoxib. Daawooyinkan waxaa ku hoos sumoobo iyo si fiican loo dulqaatay by jidhka.

Description of "Celecoxib" daroogada

celecoxib Maandooriyaha uu leeyahay midab cirro leh huruud ah iyo waxa loola jeedaa coxibs group oo muujiyaan Iscelin xushay nooca labaad cyclooxygenase ah. Medicaments ku salaysan xeryahooda Xasilay hantiyi kaga hadlay guryaha anti-bararka iyo xanuunka. daroogada asalka ku saleysan celecoxib waxaa loo arkaa in la horumariyo by shirkadda American "Pfizer" daroogada "Celebrex". waxay ahayd bartay iyo baaritaan sifooyinka pharmacodynamic sumoobo in jidhka bini'aadamka.

The medicaments kale ku jiraan celecoxib walaxda firfircoon yihiin generic, oo ay ku jiraan daroogada "celecoxib".

foomamka qiyaasta

daroogada Available in kaabsoosha gelatin adag ee qiyaasta ah ee firfircoon, 100 mg oo 200 mg. Si ka duwan wakiilada kale ee aan steroid anti-bararka, waxay leedahay qaab qiyaasta lahayn sida cadar, gel, xal isku duro ama ganaax. Iyada oo qaar ka mid ah bukaanka si qalad ah loo yaqaan foomka sii daayo "Celecoxib" daroogada - kiniin, inkastoo aan ka hadlayno kaabsulka ah.

Qaab-dhismeedka

Walaxda firfircoon waa shay celecoxib qadarkuu of 100 mg oo 200 mg. Halabuurka The of kaabsoosha ka mid ah qaybaha kaabayaal ah in ay bixiyaan buuxinta meel bannaan, flowability iyo xasiloonida of ey isku granulated. Kuwaas waxaa ka mid lactose, sodium lauryl sulfate, polyvinylpyrrolidone (K30), croscarmellose sodium, milmahayn magnesium.

Ku lifaaqan buugan daroogada "celecoxib" edbinta ka kooban yahay ee Halabuurka iyo muuqaalka caan ku qolof kaabsal gelatin a. Sida uu sharaxaad ka, waxa ay u muuqataa ugu maqlaan, waxay leeyihiin dhow cad ee midabka iyo calaamooyin "100" ama "200" calaamadeeyay, yaal guutadii buluug ama jaalle ah, siday u kala horreeyaan. Tani waxay u ogolaaneysaa in la kala saaro kaabsoosha la qaadashada kala duwan. Qaab dhismeedka of Daac jaalaha ah, iyo buluug ayaa sidoo kale rinji faahfaahsan oo muujinaysa formaldehyde aan dhib lahayn si ay u shaqeeyo.

daawooyinka la mid ah

wax soo saarka dawo "Celecoxib", analogues ah kaas oo sidoo kale ku jira celecoxib walaxda firfircoon, muujiyaan karo saameyn la mid ah daweynta on osteoarthritis of lafaha aadanaha.

daroogada asalka ah "Celebrex" iyo generic "Celecoxib", "Artoksib", "Zitsel", "Revmoksib", "Ranseleks" waxaa loo tixgeliyaa Daawooyinka. Si kastaba ha ahaatee, qaybta qiimaha asalka ah ku kici doonaa amar of magnitude ka qaalisan dhigooda.

In diyaarinta "Celebrex" waxaa ku jira celecoxib ee qiyaasta ah 100 iyo 200 mg sida a medicament "celecoxib". qaybaha darran oo ka mid ah kaabsal iyo bashqad labadoodaba laga yaabaa inay ku kala duwan yihiin ka kooban oo tayo iyo tiroba in wax saameyn ah kuma xoolahooda. Ku saabsan qaab la sii daayo "Celecoxib" analogues daroogada generic waxaa la soo saaray oo kaliya in kaabsoosha gelatin adag si loogu isticmaalo gudaha.

Waxaa jira non-steroidal anti-bararka wakiilada, cyclooxygenase si siman ay khuseyso in nooca labaad, laakiin kala duwan isagoo ka kooban ee ka kooban firfircoon, pharmacokinetic iyo sifooyinka pharmacodynamic. Kuwaas waxaa ka mid nimesulide xarunta sulfonamide taas oo in qiyaasta maalin kasta of 200 mg wax ku ool ah oo daawaynaya calaamadaha osteoarthritis iyo rheumatoid arthritis. Daawooyinka oo ku salaysan ay saamayn anti-bararka iyo xanuunka by anada cyclooxygenase labaad iyo ilaa xad yar - oo ah nooca ugu horeysay, saamayn ku noocyo kala duwan oo dhexdhexaadiyayaal ka ah xanuun iyo barar.

Sida nimesulide, celecoxib waa wakiilka fasalka sulfonamide walxaha, iyo sidoo kale in qiyaasta maalin kasta of 200 mg tiraa calaamadaha osteoarthritis. Waxa aanu la xakameeyo nooca cyclooxygenase hore iyo falalka on tiro yar oo dhexdhexaadiyayaal ka ah xanuun iyo barar.

An coxibs dawayno kale maamulka afka jira noocyo mudo oo NSAIDs. Mid ka mid ah faa'iidooyinka ugu weyn ee "Celecoxib" wax soo saarka - qiimaha. Cirbadaha (ampoules la isku duro) daroogo kale non-steroidal anti-bararka ku kici qaalisan, laakiin oolnimada duro sida waa ka fog ka xoogbadan, in natiijada ka soo isticmaalka daroogada foomamka adag.

hab of action

Drug "Celecoxib" - daroogada ka dhigan jiil cusub oo wakiilada magnyl anti-bararka, anti-bararka, xanuunka, hawl qandhada. Its qaab hawleed waxa uu la xidhiidhaa ka xanibeen formation of prostaglandins bararka by yareynta hawlaha ee Cox-2.

hawomareenka keeni induction ee nooca labaad cyclooxygenase, oo iyana dedejisaa raasamaal ee Avv prostaglandin iyo walxaha in kor loogu qaado caabuq. State yeesho barar iyo xanuun.

nooca ugu horeysay Cyclooxygenase waxba uma dhimeyso dose "celecoxib" diyaarinta daweynta. Tilmaamaha loogu isticmaalo qeexayaa tiiro ee daroogada si ixtiraam leh in enzyme this la xidhiidha hawlaha geedi socodka nafsaaniga ah ee ka dhaca unugyada ka mid ah dhismayaashii iyo mindhicirka mareenka iyo dhiig xinjirowga ay.

Sidoo kale, tilmaamaha la siiyay xog ku saabsan saamaynta daroogada on kelyaha. Under tallaabada ee celecoxib uu ka yar yahay soo bandhigay in prostaglandin Halabuurka kaadida E2 iyo F1 of 6-Keto-prostaglandin, laakiin aysan waxba ka beddelin qoondaynta of B2 11-dehydro-thromboxane, taasoo muujinaysa in daawada saamayn la xushay.

Isticmaalka daroogada "Celecoxib" uusan noqonin mid horseeda in hoos u dhac in heerka sifeynta ee glomeruli kelyaha dadka waayeelka ah iyo in bukaanka qaba la'aan kelyaha.

Tilmaamayaasha loo isticmaalo

Sida laga soo xigtay sifooyinka pharmacodynamic diyaarinta "celecoxib" codsiga waxa ay noqon doontaa wax ku ool ah oo lagu daweeyo arthritis rheumatoid iyo psoriatic, caabuq chronic xanuunka dhabarta iyo sacroiliac xubnaha iyo osteoarthritis.

Sababo la xiriira hantida xanuunka loo isticmaalo xaalad daran xanuun muruqyada ka dib markii qalliinka daaweynta, dysmenorrhea, kaas oo la Ulasocto caadada xanuun badan. The saamayn anti-bararka ah ee daroogada la golleeyahay in lagu yareeyo outgrowths iyo polyps in walamadka iyo malawadka ee cudurka of "polyposis adenomatous".

Sida loo qaato

Qaado daawada tilmaamaha "Celecoxib" si loogu isticmaalo gudaha ku talinaysaa in aan ku xirmaya isticmaalka cuntada. kaabsoosha The ha furin oo aan calalin, oo wuxuu liqay oo dhan by cabo biyo fara badan.

Lacagta ugu badan ee celecoxib, kaas oo waxaa laga yaabaa in maalin kasta waa 0.4 g diyaarinta waxaa loo isticmaalaa in ka badan oo kaliya xaalado dhif ah.

dhibaatooyin wadnaha keeni kartaa qaadasho sare iyo daaweynta dheer daroogada "Celecoxib" ah. Hagaha waxaa ku jira macluumaad ku saabsan qaadashada yar oo lagu daweeyo calaamadaha of reading kasta. Waxay bixisaa talooyin ku saabsan isticmaalka gaaban.

Si aad u baabi'iyo calaamadaha la xiriira osteoarthritis, iyo spondylitis ankylosing, maalin walba mid ama laba jeer la 200 mg ah ee daawada.

Si aad u baabi'iyo calaamadaha rheumatoid arthritis isticmaalaya dose maalinle ah 200 ama 400 mg, kaas oo loo qaaday sidii laba jeer.

Xanuun iyo dysmenorrhea aasaasiga ah waxaa lagu daaweeyaa maalinteedii kowaad dhoos sare oo 400 mg, iyadoo soo dhaweynta suurto galka ah ee dheeraad ah 200 mg, maalin kasta oo isticmaalaya 200 mg 2 jeer maalintii.

Dadka waayeelka ah, iyo dadka bukaanka ah isagoo degree fudud beerka ku filnayn ama khafiif ama dhexdhexaad la'aan kelyaha, u xisaabin lahayn dose waa la fuliyay.

miisaanka Low (in ka yar 50 kg), darnaanta celcelis ahaan beerka - qaybaha xogta bukaanka lagu daweeyaa qaadasho yar yahay ee daawo loo qoray.

Sida caadiga ah, waayo, daaweynta ee geedi socodka bararka jira laabatooyinka isticmaalo hababka daaweynta ku salaysan isticmaalka daroogada dhowr foomamka qiyaasta kala duwan. Isku "celecoxib" kaabsal, cadar, ama kululaaneysa nooca-gel "Apizatrona" ama "finalgon. isticmaalka jirka la mariyo ee sababa saamayn ku meel gaadh ah, si ay u la wada isticmaalo daroogada ee qaabilaadda indoor.

Wuxu joojinayaa isticmaalka

oo dhan bukaanka qaba cudurada kalagoysyada ma, waxaad qaadan kartaa "Celecoxib" daroogada. Tilmaamaha loogu isticmaalo waxaa ku qoran liiska cudurrada iyo xaaladaha taas oo qalab dheeraad ah oo ku yeeli doona badan oo wanaagsan. Kuwaas waxaa ka mid ah:

• finan, neefta, xaalad xasaasiyad by tallaabada ee aspirin iyo daawooyin kale magnyl anti-bararka,
• hawlgalka soo kabashada la xidhiidha halbowlaha wadnaha Grafting isku tallaalidda ;
• sii daridda ah boog ulcer,
• caloosha iyo xiidmaha dhiig;
• caabuq xabka ee mindhicirrada ah;
• wadnaha,
• cudurada ischaemic ee muruqa wadnaha,
• luminta xididdada durugsan iyo weelashii cerebral la socodka dhiigga maskaxda oo yaraada;
• qaabka nedostatochnosttyazheloy cagaarshowga;
• kelyaha ee daran;
• dhalmada;
• naas nuujinta ilmaha;
• da'doodu ka yar tahay siddeed iyo toban sannadood;
• diidmo in excipients;
• kor u nuglaato qayb sulfonamide ah.

Iyada oo la isticmaalo si taxadir ah "Celecoxib" daroogada waa in dadka qaba cudurada of mareenka caloosha iyo mindhicirka la xiriira dhiig boog ulcer ee la soo dhaafay, cudurka oo ka mid ah bakteeriyada-axaleedka of panulirus Helicobacter Pylori ah.

haynta biyaha ee bararka jirka iyo unugyada jilicsan ka, xanuunada ku dhaca beerka cudurada sare stage, wadnaha iyo xididdada dhiigga, ee jirka, kuna waari dhexdeeda korodhka heerka kolestaroolka in plasma dhiigga arkay-shiid la egyahay, diabetes, sonkorta, cudurrada degaaankaaga, in aad u daran iyo sabab ah ugu badnaan isticmaalka taxadir daroogada "celecoxib" ee iyada oo ay kormeerayaan dhakhtar.

waxyeellooyin

Inkastoo guulaha cusub ee abuurka ah ee jiil cusub oo coxibs, kuwaas oo walxaha iyo daroogada ku saleysan iyaga ma yihiin wax garad waxyeelo.

Socda daroogada tilmaamaha "Celecoxib" loo isticmaalo, Kurtumm bukaanka iyo khabiiro - ilo ku jiro war ku saabsan saamaynta gurracan ee suurogalka ah waxa dhici kara in in xubnaha muhiimka ah.

Saamaynta ay suurtagal tahay negative on nidaamka dheefshiidka lagu gartaa NSAID-gastropathy, xanuun caloosha, yaqyaqsi, matag, laab ah, hoos u baahida loo qabo in cunto qaadashada iyo shuban. Isticmaalka muddada dheer ee qaadasho sare waxay keeni kartaa ulceration iyo dhiig in xuub-axaleedka of caloosha iyo mindhicirrada, dhiig-ciridka, dardargelinta-dhaafka ah ee beerka transferase ah.

xanuunada habdhiska waxaa muujiyey farax, madax-xanuun, wareer, somnolence, hurdo la'aan, dalalka niyad.

Saameynta nidaamka wadnaha ay sabab u tahay cadaadiska kordhay halbowleyaasha, iyo tachycardia.

Diyaarinta "celecoxib" yaraynaysaa caabiga cudurada faafa ee qaabka neefsashada, kaas oo lagu sheegi karaa in horumarinta hogaga, rhinitt, pharyngitis, xanuun sanka iyo cunaha, qufac, dyspnea, bronchospasm.

Saamaynta daroogada on dareenka keena hoos u dhac ku aragtida maqalka iyo muuqaalka kore ee tinnitus.

On habka kaadida saamayn ku daroogada "Celecoxib" si aad u qaadataan wixii renal failure horumarinta bararka syndrome.

Iyadoo la tixgelinayo xubnaha dhiig-sameynta ee, daroogada waxay keeni kartaa muujinta Agranulocytosis, dhiig yari, leucopenia, Torombositobiiniya.

finan maqaarka yaabaa inay ku dhacaan muuqaalka kore ee pruritus xasaasiyad, urtikaria, photosensitivity, anjioedema ee gobolka wajiga, jirka, xubnaha taranka.

Features soo dhaweynta

Drug "Celecoxib" khasaaro soo jireenka ah ee la xidhiidha halis kordhaysa oo ah waxyeello ka soo gaartey oo ku saabsan nidaamka wadnaha taasoo keentay in thrombosis, Wadnaxanuun of myocardial cajiib ah murqaha iyo stroke. Gaar ahaan korodhka halista intii uu jiray maamulkii chronic daawada by bukaanka kan waxaa jira cudurrada wadnaha.

Si loo yareeyo halista dhibaatooyin sida in bukaanka qaadanaya "Celecoxib" daroogada qoro qiyaasta ugu hooseeya ee ugu muddada gaaban ee daaweynta. Bukaanka waa la tashato dhakhtarkaaga calaamadaha suurto galka ah ee cudurka iyo si aad u hesho talo ku saabsan sida in ay ka jawaabaan marka ay dhacaan.

isticmaalaan iskujir ah acetylsalicylic acid ee qaadasho yar in ay daroogada "celecoxib" Si loo yareeyo calaamadaha wadnaha. Reviews dhakhtarro tilmaamaya saamayn antiplatelet ah ee aspirin si khafiif ah dhiigga marka la qaadanayo coxibs, kuwaas oo aan lahayn guryaha anti-thrombotic sida. Sida caadiga ah, isku darka noocan oo kale ah lagu muujiyay in bukaanada waayeelka qaba cudurada nidaamka muruqyada iyo nidaamka wadnaha, caloosha iyo mindhicirka sumoobo u korodho marka aan la xushay non-steroidal anti-bararka. Laakiin isticmaalka celecoxib walax la NSAIDs kale laguma talinayo.

Bukaanka qaba dhiig kar sare, la socodka joogtada ah ee u dhimaya nabadgelyada this marka la helo "Celecoxib" daroogada.

fiiro gaar ah waa in la siiyaa la socodka xaaladda shaqeeyo isku dhafan oo xinjirowga (warfarin) iyo walxaha antiplatelet (acetylsalicylic acid, clopidogrel) isticmaalaya inhibitors xushay (Citalopram, sertraline), anada reuptake inhibitors serotonin of isozyme CYP2C9, foomamka kiniin glucocorticosteroids.

The daroogada "celecoxib" kor u wax soo saarka ee walxaha prostaglandin, kaas oo dhex faafiyo dareeraha ee jirka oo kor u qaado horumarka of bararka. Feejignaadaa in daaweynta daawooyinka waxay u baahan yihiin in ay dadka ay dhibaatadu ka muruqa wadnaha iyo cadaadiska dhiigga ee sareeya. waa in ay joojiyaan qaadashada "Celecoxib" daroogada haddii ay jiraan calaamadaha barar unugyada.

Bukaanka qaba coxibs daaweynta cudurada kelyaha waa in uu la socdaa kormeer joogta ah tilmaamayaasha muhiimka ah.

Marka fuuq qaadashada daroogada ayaa suuragal ah keliya ka dib markii rehydration Dabcan fuuqcelinta ah.

Reception "celecoxib" daroogada qandhada ay sabab u tahay tallaabo keenaysaa in dhibaato ah index ogaanshaha, sida heerkulka kacsantahay inta lagu guda jiro horumarinta xaaladaha faafa.

tallaabo ee daroogada waxay keeni kartaa caadi ahayn ee beerka, gaar ahaan dadka qaba pre-jira xanuunada beerka. calaamadaha daran ee la xiriira hepatitis fulminant, nekrozomtkaney beerka. Xaaladaha noocan oo kale ah isla markiiba dhacaan, laakiin kaliya ka dib 30 maalmood ka dib markii codsiga "celecoxib" diyaarinta. Markaas aad rabto si ay ula socdaan waxqabadka ee daaweynta ee beerka xarunta this, iyo in ay dhacdo guuldarro culus waa in aad si degdeg ah u joojiso balanta.

Reviews lagu daaweyn jiray "Celecoxib"

daawooyinka anti-bararka magnyl waa la fuliyay oo kaliya on qoro. Natiijada isticmaalka "Celecoxib" dib u eegista daroogada ay tallaabo waa isku dhafan. Mid ka mid ah daawooyinka ka caawisaa si ay ula qabsadaan geedi socodka bararka ee laabatooyinka, kuwa kale waa natiijo la'aan iyo sababa tiro ka mid ah dhacdooyinkan gurracan.

Sida bukaanka more qiimeeyo daroogada "Celecoxib"? Reviews ayaa tilmaamaya tiro ka mid ah dhibaatooyinka: xanuun caloosha, kelyaha, xanuunada caadada. dhakhtar bukaan noocan oo kale sameeyaa medicament joojiyo wareejiyaa daaweyn kale.

Iyada oo ku saleysan aragtida dadka bukaanka ah ee ku saabsan saamaynta maandooriyayaasha ku xunbo barar, waxaa lagu soo gabagabeeyey karaa in ay tahay wax ku ool ah ee dagaalka ka dhanka ah arthritis. Si aad u baabi'iyo calaamadaha xanuunka, barar unugyada in meesha ay dhibaatadu saameysey ee dabiiciga ah ee joogtada ah, bukaanka ku jira dayrta iyo guga heerka of therapy daroogada "Celecoxib" ah. Waxaa loo isticmaalaa by ciyaartoyda in dhaawacyada iyo kala goysyada.

Gaar ahaan medicament u dhaqmo si waxtar leh isku dhafan oo dabka kulaalaya cadar iyo jel codsiga la mariyo. Si kastaba ha ahaatee, sida uu sheegay talooyin ku jira tilmaamaha loo isticmaalo siiyey NSAID isticmaali koorsooyin gaagaaban, si looga fogaado stress on kelyaha, beerka, wadnaha iyo caloosha. Haddii aan si looga fogaado in fashilaad in shaqada hay'adaha kuwan.