Daawada "Leykostim": tilmaamaha loo isticmaalo, dhigooda dhabta ah

Waa maxay daawada "Leykostim"? Tilmaamaha, foomka sii daayo, tilmaamo iyo sababo in daroogada taas waxaa loo hoos ku qeexan doonaa. Waxa kale oo aanu kuu sheegi ku saabsan waxa analogs ayaa diyaar u ah qalab this waxaa ka mid ah in ay ka kooban, iyo wixii la mid ah.

Qaabka uu leeyahay, baakadaha, qayb ka mid ah daroogada

Waa maxay foomka ma daroogada "Leykostim"? Tilmaamaha loogu isticmaalo ayaa sheegay in medicament firfircoon waxaa soo saaray in ay xal u ah maamulka subcutaneous ama xididka.

qayb firfircoon ee wakiilka waa filgrastim. Waa arrin recombinant granulocyte gumeysi-madadaalo. 1 ml of xal daroogada ku jiri kara 300 mg (30 million. IU), 600 mg (60 million. IU) ama 150 micrograms (15 million. I.U.) filgrastim.

Sida excipients ah, ka dibna ay u isticmaalaan sida mannitol, sodium copolymer trihydrate, dextran, acetic acid, polysorbate, iyo biyo la isku duro.

In xal baakadaha la iibiyey "Leykostim"? Tilmaamaha loogu isticmaalo gundhig in kartoon ah oo si wadajir ah ula mid ama shan fijaan ee daroogada.

The sifooyinka daroogada

Waa maxay hab ay of tallaabo daroogada ee "Leykostim"? Tilmaamaha loogu isticmaalo, dib u eegista dhakhaatiirta waxa ay sheegayaan in a-immunomodulator daroogada. Waa protein a non-glycosylated heer sare ah la safeeyey in uu saamayn sharciyeed ku saabsan horumarinta iyo dhaqdhaqaaqa (ka dhuuxa lafta dhiiga) neutrophils functional.

Ka dib markii hordhaca ah ee daroogada si weyn u kordhiyaa tirada neutrophils ee dhiigga iyo wax yar oo kaliya - monocytes. Tani waxay dhacdaa 24 saacadood gudahood.

Kororka neutrophils dhiigga waa qiyaas ku tiirsan. Generation of protein bayoloji firfircoon, i.e. filgrastim, oo normalizes ku soo batay iyo kala unugyada qaadeen by nooc oo ka mid ah bakteeriyada coli Escherichia. Waana mid ka, dambaysta ah, sababo la xiriira awoodaha of injineernimada hidde casriga ah, dhammaystirayaa gumeysi granulocyte hiddo madadaalo factor aadanaha.

Sida laga soo xigtay in uu mabda 'ah saamaynta on jidhka daroogada la mid tahay isir granulocyte gumeysi-madadaalo, taas oo asal ahaan dabiiciga ah. Faraqa kaliya ee waa xaqiiqooyinka ay "Leykostim" (xal) aan glycosylated, oo uu leeyahay N-terminal ka hadhay amino acid of methionine.

Features of daroogada

Waa maxay astaamaha uu leeyahay daawada "Leykostim"? Tilmaamaha Isticmaalka sheegayaa in ay tahay in loo isticmaalo in cudurka of neutropenia in dadka mari chemotherapy. Sidoo kale, daroogada waa mid aad waxtar u leh neutropenia chronic. Tan waxa u sabab xaqiiqda ah in uu awoodo in la soo celiyo tirada isitcmaalo neutrophils ee jirka aadanaha.

Isticmaalka dejinta ee ka hortagga, bukaanka si weyn hoos ugu dhigi kartaa dhacdooyinka neutropenia, iyo sidoo kale yareeyo dhibka ka mid ah socodka iyo wakhtiga muddada cudurka ka. gaadhista noocan oo kale ah ka hortagtaa dhibaatooyinka faafa, dhererka bukaanka ah ee isbitaalka la dhimay, ogolaanaya chemotherapy aan ka fogaadaan erayada in la aasaasay nidaamka guud ee daaweynta.

Sida jidhka bini'aadamka u dhaqmo "Leykostim"? Tilmaamaha loogu isticmaalo muujinaysaa in isticmaalka daroogada kordhinayaan in jihada in unugyada dhiigga durugsan hematopoiesis ka hor, kaas oo lagu soo ururiyay by cytapheresis (i.e., kala dhiig galay qayb gacanta la saarayo wuxuu xushay) loona maamulay si ay bukaan ka dib markii koorso of-dose sare chemotherapy.

Taa baddalkeeda, unugyada isku duro (stem) isagoo shaqo hematopoietic, hoos habka difaaca iyo hematopoietic, iyo sidoo kale in la yareeyo khatarta iyo adkaanta dhibaatooyin faafa iyo dhiigbaxa.

ammaanka daawo

Waa ammaan ah daroogada aadanaha "Leykostim"? dalalka Buugga in daroogada taas waxaa loo isticmaali karaa carruurta iyo dadka waaweyn labadaba. Waxaa si siman ammaan u ah dadka oo dhan helo chemotherapy cytotoxic.

Bukaanka qaba xal codsiga fayraska dila difaaca jidhka bixisaa heerka mug leh neutrophils iyo siinayaa fursad ay ku soo raaci oo dhan qaadashada taliyay therapy antiretroviral ama myelosuppressive.

Marka la isticmaalayo alaabta this of taranka HIV ayaa lagu arkay.

Pharmacokinetics

Waa maxay daawada pharmacokinetic leeyahay "Leykostim"? Waxbarashada waxay muujinaysaa in fiirsashada of qayb firfircoon ee wakiilka tani waa si toos ah ay ku xidhan tahay qiyaasta ay maamusho.

Ka dib markii maamulka subcutaneous, qadarka weyn ee daroogada ee dhiigga ku arkay ka dib markii qiyaastii 8-15 saacadood.

bar-nolosha "Leykostima" Qoraalkani wuxuu ku firfircoon yahay saddex ilaa afar saacadood. Filgrastim metabolized in peptides. About 1% ka mid ah qayb firfircoon u muuqataa beddelin kaadida.

raasamaal Filgrastim ee jidhka bini'aadamka ma dhici karto xitaa isticmaalka daba dheeraaday ee daroogada (marka therapy ka badan bil) ka dib. In muddo this ay bar-nolosha waa isku mid.

Tilmaamayaasha

"Leykostim" Dawada waxa laguu qoray ee ujeeddooyinka soo socda:

• lagu yareeyo mudada socodka neutropenia tallaabooyinka 2-4, iyo sidoo kale in la yareeyo dhacdooyinka neutropenia xummada in aadanuhu kasoobaxyo nemieloproliferativnymi ka dib markii chemotherapy la wakiilada cytostatic;
• si loo yareeyo daliilka dhibaatooyin ka kici markii neutropenia, iyo sidoo kale yaraynta dabcan markii ugu of cudurka aadanaha lagu chemotherapy myeloablative la dhuuxa lafta lagama maarmaan badalida,
• Meelaha gacanta horaysa hematopoiesis in dhiigga durugsan ujeeddo ah kala iyo iyaga transplanting ka dib markii chemotherapy myelosuppressive;
• oo lagu daweeyo neutropenia in dadka qaba cudurka HIV (oo ay ku jiraan kuwa heerka ugu sareeya) si loo yareeyo khatarta cudurada faafa ee asal ahaan bakteeriyada,
• oo lagu daweeyo neutropenia chronic;
• meelaha cell hematopoiesis ka hor, in dhiigga durugsan ee deeq caafimaad in la transplanted oo u kala sooci buka.

sababo

Waa maxay daawada sababo leeyahay "Leykostim"? xirfadlayaasha Reviews sheegay in laga reebay soo socda:

• kordhay dareenka shakhsi ahaaneed ee bukaanka in la sinji iyo kuwa kale ee halabuurka ah ee daroogada;
• neutropenia lagu dhasho, iyo Wabiyadan socota daran ee xanuunada cytogenetic (Kostmann syndrome);
• muddo dhalaanka (gaar ahaan bishii kowaad ee nolosha).

Drug "Leykostim": waxbarida iyo codsiga

daawo viewed loo qaadan karaa laba siyaabood:

• intravenously;
• subcutant.

Qiyaasta iyo habka maamulka "Leykostima" waa in la go'aamiyey by khubaro, ku xiran tahay xaaladda caafimaad, sifooyinka gaarka ah ee bukaan-socodka iyo cudurka. Si kastaba ha ahaatee, waa in la ogaadaa in waxa dhaqanka caafimaad waxaa la doorbiday maamulka subcutaneous of daroogada.

Waayo, medicament firfircoon xididka waa laga saaray weelka by saliingaha, ka dibna waxaa lagu daray weel 5% dextrose. Xalka ugu taasoo keentay in la maamulo bukaanka ah nus-saac.

Sida loo codsado "Leykostim"? Tilmaamaha (analogues of dawadan la hoos looga hadli doonaa) dhigayaa in daroogada waa in la isticmaalaa aan ka horeyn ka badan maalin ka dib dhamaadka chemotherapy.

xal daroogada ayaa waxaa la maamulo ku xiran tahay miisaanka bukaanka. dose safafka of 5-12 mg halkii miisaanka 1 kg. Cirbadaha lagu sameeyaa maalin kasta la soo noqnoqoshada ah hal mar maalintii.

Therapy waxaa loo arkaa daroogada Waa in la fuliyo ilaa iyo inta tirada neutrophils dhiigga ku aadan gaaraan heerarka caadiga ah. Sida caadiga ah, muddada daawaynta waa laba toddobaad.

Inta lagu jiro maamulka ku takhasusay waxaa looga baahan yahay in si joogto ah loo ogaado tirada leukocytes ee dhiigga. Haddii tirada waa ka weyn yahay 50,000 / microliter, daroogada rogay.

Inta lagu jiro daaweynta, bukaanka waxaa laga yaabaa in la horumariyo Torombositobiiniya. In kiiska ku assays soo noqnoqda qiimaha dhiig xinjirowga count waa la hayaa hoos 100,000 / microliter, ka dibna baarayaa la joojiyo ku meel gaar ah ee daroogada ama dhimista ay qiyaasta.

waxyeellooyin

Sida laga soo xigtay tirakoob, daroogada "Leykostim" dhif keena dhibaato. Si kastaba ha ahaatee, weli ka gaysan karaan in ay soo bixitaanka of saamaynta sida:

• gubta,
• xanuun lafaha ama murqaha;
• alopecia;
• hepatomegaly, splenomegaly;
• hypotension (transient);
• heerka sii kordhaya ee acid uric iyo phosphatase xumadoodu;
• daciifnimo, madax xanuun iyo daal,
• dareen diidmo oo xasaasiyadeed ee bilowga ah ee daaweynta, taas oo inta badan ka dhacaan ka dib markii maamulka xididka of daroogada.

Sidoo kale waa in la ogaadaa in marka cirbad aan sax ahayn ku dhibin laga yaabaa raaxo bukaanka goobta la duray.

isdhexgalka daroogada

Ka hor inta la isticmaalayo daroogada this, waa in aad ogaato sidaad si ay ula falgalaan daawooyin kale "Leykostim". Tilmaamaha (INN daawada u muuqataa sidii "filgrastim") waxaa ku qoran warar dhamaystiran iyada oo loo marayo:

• Medicament "5-Fu" xoojisaa neutropenia.
• Maxaa yeelay, sii kordhaya unugyada myeloid waa mid aad u xasaasi u ah wakiilada cytotoxic, in uu magacaabo "Leykostim" waa in ay maalin ka hor ama ka dib isticmaalka daawooyinkan.
• medicament viewed leheyn chloride sodium.
• Marka la isticmaalayo xal u ah jihada of unugyada progenitor socda chemotherapy loo tixgeliyo in kartida hoos marka codsiga abaabulka waajib "carmustine" ee "Melphalan" iyo "carboplatin".

talooyin gaar ah

Waxaa laguma talinayo in ay u yeelaan dadka qaba beerka si daciif ah iyo kelyaha "Leykostim", sida ammaanka filgrastim iyo oggolyahay in bukaanka kuwaas oo aan la bartay.

Bukaanka qaba osteoporosis iyo cudurada kale ee lafaha, isticmaala daroogada si joogto ah muddo lix bilood ah, waa in aad samayn gacanta ugu cufnaanta lafaha.

Saamayntii daroogada ee dadka qaba qadar yar oo ah unugyada progenitor myeloid aan la bartay. Si kastaba ha ahaatee, khubarada ku doodaya in bukaanka sida heerka uu kordhay tirada neutrophils noqon kartaa si weyn u hooseeya.

Oggolyahay iyo ammaanka "Leykostima" in dadka qaba kansarka dhiigga myeloid chronic iyo myelodysplastic syndrome aan la aasaasay. In xiriir this, in cudurada sida aan la tusay.

Monotherapy fikiray daroogada ka hortagtaa anemia iyo Torombositobiiniya, taas waxaa keena chemotherapy myelosuppressive. Waxaa loo baahan yahay si loo ogaado tirada platelets iyo hiimotokiriit. taxaddar gaar ah waa in loogu dhaqmaa marka la isticmaalayo hal-qayb ama isku darka daawada kiimikada, lagu yaqaan in ay awood u keeni Torombositobiiniya daran.

Ka hor inta aadan bilaabin daawaynta, "Leykostimom" loo baahan yahay si loo sameeyo falanqayn faahfaahsan oo dhiig leh xaddi gaar ah oo dhiig xinjirowga sameeya oo leukocyte dacwadood, oo baadhaan karyotype iyo lafta sawirka dhuuxa.

Inta lagu jiro muddada daawaynta loo baahan yahay in si joogto ah loola socdo ee kaadida iyo size of caajisnimo ah.

Drug "Leykostim": analogs iyo qiimaha

daroogada analogues waxaa loo tixgeliyaa in dawooyinka soo socda: "Filergim", "Grasalva", "Granogen", "Neupogen," "leucite", "Neypomaks", "Mielastra", "Neyrostim".

Sida qiimaha, ka dibna "Leykostima" waa mid aad u sarreeya. daroogada this farmasiyada iibso ee Moscow iyo magaalooyin kale Ruush noqon kartaa of 2500-4500 rubles. Qiimaha dawadan waxay ku xiran tahay inta uu le'eg yahay iyo tirada ampoules halkii pack.

Reviews daawo

Nasiib darro, dib u eegista bukaanada qaata this daroogada, aad u yar. Sida xaqiiqada ah in ay jiraan, daawada inta badan loogu nidaamka difaaca jirka, iyo sidoo kale neutropenia xilliile ah ee carruurta. Saamaynta daroogada in cudurro halis ah sida gaaban tahay.

Sidoo kale waa in la ogaadaa in ay jiraan Kurtumm bukaanka ku saabsan isticmaalka caafimaad ee "Leykostima" ee caruurta iyo dadka waaweyn ee la xiriira neutropenia chemotherapy kansarka. Dhallaanka Diyaarinta loo xilsaaray in qiyaasta a of 5 mg / kg maalintii, halkii ay si fiican loo dulqaatay.

Bukaanjiifka qaar xiiso su'aasha ku saabsan nooca xal waa ka wanaagsan yahay: "Leykostim" ama "Neupogen". Sidaas darteed of tijaabo in la fuliyey si loo garto tolerability iyo Diidmada ay of wakiilada kuwan, gabagabadii soo socda ayaa lagu gaarey, waqtiyada iyo hagaajinta ee neutropenia ka dib markii la isticmaalayo daawooyinka ku xusan ma aha Sharaf. Waxaa intaa dheer, waxa ay leeyihiin si dhab ah tilmaamayaasha la mid ah waxtarka iyo tolerability.