"Dopamine" - waxa in? "Dopamine": waxbarida, codsiga, qiimaha

The daroogada "dopamine" u eg budada crystalline ah midab cad leh caraf dirqi la geran karo Aashito. Foomkan waxa uu leeyahay qaab hydrochloride. "Dopamine" - walax milma biyaha iyo khamriga. Waxaa la saameeyeen alkalis, wakiilada oksidheeyeyaal kala duwan iyo cusbada oo bir ah. Tilmaamayaasha iyo sababo isticmaalka daroogada "dopamine" ka, edbinta on isticmaalkeeda waxaa la geeyaa publications our.

Waxaa loola jeedaa saaray sidii shancosbitaal xal galiyey.

sifooyinka pharmacological

"Dopamine" - walax, neurotransmitter ah. On the guryaha dheefshiidka ee dopamine waa maamaan ah adrenaline iyo noradrenaliin. daroogada ayaa saamayn ku receptors u dhiganta, iyo in ay isugu soo urureen sare wanaajisaa α- shaqada iyo β-adrenoreceptors. "Dopamine" shaqada waxaa loogu talagalay:

• gol leeyahay iska caabin dhuumaha ugu sarreeya;
• kordhiyo cadaadiska dhiigga systolic;
• kicinta heerka garaaca wadnahaaga,
• korodhay wax soo saarka wadnaha;
• isbedel yar oo garaaca wadnaha,
• sahayda oxygen la taaban karo.

"Dopamine" ayaa sidoo kale kor u socodka dhiigga ee weelashii maskaxda, wadnaha, kelyaha iyo mindhicirrada ah. La kordhiyo heerka sifeynta glomerular iyo Digo sodium by kelyaha.

"Dopamine" - daroogada soon-simaha. 5-10 daqiiqo ka dib ka dib markii i / hawlgal v galiyey dhamaado. The bar-nolosha - qiyaastii laba daqiiqo. Half maalkii macaamila protein ah ee plasma dhiigga. Daawada maraa habka dheef degdeg ah plasma kelyaha, beerka iyo dhiigga sabab u tahay saameynta ay MAO iyo catechol-O-methyltransferase in xaalad ah metabolites aan firfircooneyn iyo si firfircoon soo saaray by kelyaha. Rubuc ka mid ah isticmaalka dose ah waxaa loo baddalaa norepinephrine ee sprouts dareemayaasha adrenergic. Sababo la tirtiridda firfircoon ma aha raasamaal ah ee daroogada ee jidhka bini'aadamka, xataa muddo dheer ka mid ah soo dhoweynta ka dib.

"Dopamine": codsiga

Tilmaamayaasha waayo, aqbaliddoodii:

• Noocyada kala duwan ee lama filaan ah, sida ku dhibaysa, cardiogenic, postoperative, hypovolemic, endotoxin.
• vascular Ba'an iyo wadnaha oo shaqadiisa gaba.
• saarka wadnaha Low.

"Dopamine" la shock cardiogenic baahida gaarka ah, u kordhiyaa function contractile myocardial.

Daawada waxaa maamula intravenously. 125 ama 400 ml oo ah shan xal boqolkiiba chloride sodium ama xal glucose loo baahan yahay 25 ama 200 mg siday u kala horreeyaan. Sayidka, 1 ml of xal u helay 200 ama 500 walax .mu.g. Haddii bukaan lama duri karo in tiro badan oo ah dheecaan oo la samayn karaa xal u xoog badan si ay 1 ml of 800 micrograms ahaa "dopamine". Si arrintan loo sameeyo, waxay qaadan 200 mg per 250 ml oo xal. Heerka sal-gaaro 1-4 ug / kg halkii daqiiqo si culayska jirka celcelis ahaan of 70 kg (2 ilaa 11 dhibcood oo xal 0.05% ama ka 1.5 ilaa 6 dhibcood oo xal 0.08%). qiyaasta daweynta - 5 ilaa 9 mg / kg 1 min. Qiyaasta "dopamine" 10-15 .mu.g / kg halkii daqiiqo waa mid waxtar leh in vasodilation iyo hypotension. Heerka Maamulka waa la kordhin karaa ilaa 18 .mu.g / kg halkii daqiiqo. galiyey qaadataa meel aan la dhexgelin oo ku aaddan tahay muddada ka 2-3 saacadood si ay 1-4 maalmood ama ka badan. Qiyaasta maalin kasta aan ka badnayn 800 mg. Iyadoo hordhaca ah ee "dopamine ayaa" waxaa la qabtaa la socodka ECG. Determination of qiyaasta iyo heerka maamul waa sida cadaadiska halbowlayaasha, garaaca wadnaha, wax soo saarka wadnaha, garaaca wadnaha iyo diuresis. Haddii hypotension ma kac, oo hoos u dhacay wax soo saarka kaadida, qiyaasta waa in la dhimay.

sababo

Daawada waa u dhacdo dhibaatooyinka sida:

• arrhythmia;
• pheochromocytoma;
• hypertrophy Prostatic;
• glaucoma xidho.

waxyeellooyin

hordhaca ah ee walaxda in qiyaasood oo waaweyn, heer sare ah "dopamine" keeni kartaa waxyeelo, oo ay ku jiraan:

• gariirka,
• tachycardia;
• vasospasm;
• arrhythmia;
• xad gudub ku ah laxanka neefsashada;
• anginal iyo madax-xanuun,
• cadhoodaan psychomotor ;
• daliilka kale tallaabo Adrenomimeticalkie.

Tan iyo tirtiridda "dopamine" waa firfircoon, calaamadaha kor ku baaba'aan haddii hoos u qiyaasta ama joojin maamulka of daroogada. Haddii laxanka waa la dumiyey, waxaa lagama maarmaan ah in la isticmaalo daroogada antiarrhythmic, oo ay ku jiraan "Verapamil", "lidocaine" iyo kuwa kale. xal Extravasation "dopamine" waxay keeni kartaa in galleeyda oo unug ka subcutaneous adipose iyo maqaarka.

ganaaxyada

"Dopamine" inta ay uurka leedahay waxaa laga yaabaa in ay ku soo rogeen kaliya marka daaweynta lama huraanka u ah hooyada, iyo saamaynta ay ku daweyn uu ka badan yahay khatarta in ilmaha caloosha ku.

xal Fresh waa in ay leeyihiin dareen taabasho ah oo hufan oo ka maqan cado Ngcuka.

daaweynta wadajira daawooyin kale

Daawada waxaa laga yaabaa in ay barbar socdaan ka glycosides wadnaha iyo diuretics (tus, furosemide oo kale). lama filaan ah Hypovolemic u baahan hordhaca ah ee "dopamine" oo ay la socdaan dhiig, plasma ama plasma bedel dhan.

Ha qaadan "dopamine" waqti isku mid ah leh "cyclopropane", MAO iyo wakiilada suuxinta la HALO ( "Halothane" iyo kuwo kale).

samaynta isku darka Madaafiic aan la aqbali karin xal cawaaqib xumadoodu waxay of daroogooyinka kale.

"Dopamine" - daawo ah oo loo isticmaalo oo kaliya on qoro. Its qiimaha ku xiran tahay qiyaasta iyo tirada ampoules in xirmo, laga bilaabo 80 ilaa 300 rubles halkii pack (5-10 ampoules).