Fangaska khamiirka-sida ee panulirus ah Candida

Sidaas dunida in qof kasta oo inaga mid ah waxaa ku hareereysan kun oo xayawaan cqaadir. Annagu waxaannu nahay iyaga ma uu arki karin isha oo qaawan, laakiin aad taabato iyaga la daqiiqad kasta. Qaar ka mid ah "aan la arki karin" naga caawiyaan, qaar kalena waa la dilay, iyo qaar kale oo keeni karo, iyo dhib iyo lacagta. fangaska khamiirka-sida ee panulirus ah Candida waa uun microbes sida aan looga hortago noo farxad ku noolaan abid ka dib, laakiin xaaladaha qaarkood ay bilaabaan inay gardarro u dhaqmaan, taasoo keenta candidiasis cudur ama cabeeb. Maxaa yeelay noolaha, kuwaas oo had iyo jeer ma aan dhib lahayn, waxaa loo yaqaannaa fursad. Total helay 186 nooc oo fangaska ee panulirus Candida ah, laakiin khatarta ah ee kaliya laba darsin noocyada. iyaga On laga wada hadli doonaa in this article.

The panulirus Candida fangaska: sifooyinka

Candida khamiir tirsan panulirus ah. Inta badan noocyada ay yihiin gebi ahaanba aan dhib lahayn oo ku nool jirka ka mid ah fangaska shaaha ee yogurt, alaabooyinka kale ee caanaha laga sameeyo, iyo sidoo kale in mareenka caloosha iyo mindhicirka nin, oo muujinaya qayb ka mid ah a flora xiidmaha caafimaad. Fungi of panulirus ah Candida tahay laylinta, ie, nolosha firfircoon joogitaanka oxygen. Waxay jiri karaan in laba nooc - khamiir iyo micellar. In khamiir fangaska waa wareeg ah ama gadood blastospores gaysashada iyo tarmeen. Foomka micellar unugyada fangas elongate, bedalayo pseudomycelia. Si ka duwan run, waxaa jira maqaal qoruhu ma, laakiin waxaa jira Cidhiidh ah. Waxay ku yaalaan blastospores, iyo ballaadhinta terminal hlamidiospory double-qiireysan. Foomka micellar fangaska ay awoodaan in ay ka qaba.

xayawaan kale ee fangaska dimorphic of panulirus ah Candida way kala duwan yihiin in ay noqon kartaa in jirka ah ee sayidkiisa in labo ka mid ah qaabkeeda, laakiin ma aha in ay iyaga u beddeli ku xiran tahay heerkulka daarmayaay'e ah.

hanti muhiim ah Candida - waxay awoodi karaan inay ferment maltose iyo glucose yihiin.

cudurka Candidiasis, sida uu sheegay baaritaano dhawaan, sababta oo ah oo ku saabsan 20 nooc oo fangaska, oo waa C.Albicans ugu khatarta badan (60%) iyo C.Tropicalis (20%). The haray 18 noocyada waxaa si weyn loo qaybiyey oo saameyn yar ku ool ah oo ku saabsan dhacdooyinka candidiasis aadan haysan.

SHARAXA KOOBAN noocyada pathogenic

The fangaska inta badan kala kulantay of panulirus ah Candida, loo yaqaan C.Albicans. sidayaal waa qiyaastii 8 ka mid ah 10. Inta badan fangaska kuwaasi waxay gali jidhka ilmaha markay dhashaan oo ku nool oo aan fiicnayn, in afka saabka, hunguriga iyo mindhicirrada. In haweenka, waxay sidoo kale ay qayb ka yihiin microflora siilka. Waa noocan oo kale ah Candida inta badan mas'uul ka dhacdo ee Candidiasis.

Nooca labaad waxa loo yaqaan khatar C.Tropicalis ah. fangaska Kuwani waa inay awoodaan in ay dhex gasho dhiiga oo ay u isticmaalan in dad xubnaha durugsan. Baaritaanadii u danbeeyay ayaa shaaca ka qaaday feature a shaqada Candida C.Tropicalis tusmo marcescens Serratia iyo coli Escherichia, iyo sababta cudurka Crohn.

Ma aha mid caadi ah, laakiin waxaa loo arkaa in ay ka fangaska ugu khatarta badan ee panulirus noocyada khamiir Candida C.Krusei. Waxay yihiin adkaysi u daroogada "fluconazole", loo isticmaalo in lagu daaweeyo cudurada boqoshaa, sidaas darteed waxaa muhiim ah in la kala nooca fungus pathogenic dhadhansiiyey bukaanka.

Fungi Candida noocyada C.Glabrata tixgeliyo non-pathogenic. Waxay ka jirin oo keliya qaab khamiirka iyo dhalid gaysashada kaliya. Xaaladaha intooda badan, Candida Glabrata ogaado on tuubooyin kaadida, halkaas oo u yeela biofilm khafiif ah. fungus Taasina waxay keentaa in candidiasis Fistula.

Candida noocyada C.Parapsilosis inta badan waxay noqotaa sabab ka mid ah sepsis. Waa awood u ah cudurka nabarka, gaar ahaan haddii walxaha shisheeye u galaan.

Nooc oo fangaska iyo C.Rugosa C.Lusitaniae iyo kuwa kale ee panulirus Candida waa mid aad u dhif ah. Tusaale ahaan, C.Lusitaniae in muddada u dhaxaysa 1979 ilaa 1990, waxaa la heli karaa oo keliya 30 bukaan.

Siyaabaha cudurka

Keeneysa la - fangaska khamiir pathogenic of panulirus ah Candida ee koorsada of horumar yeelatay habab ka caawiya iyaga in ay u horseedi jiritaanka a Dulin. Waxay ka adkaan karin keydsho muddada-dheer iyo qallajinta awoodaan. Ku qor jidhka bini'aadamka, waxay noqon karaan cunto wasakh ah iyo si liidata baaraandegi leh gacmaha wasakhda iyo walxaha kale, sida likaha qaadsiin C.Parapsilosis boogaha la dhexgalka ee walxaha shisheeye, oo ay ku jiraan oo aan jeermis alaabtii caafimaad iyo likaha C.Glabrata la kaadida ama kateetarka xididka. Inta badan qaadsiiyay by fangaska noocyada C.Albicans, iyo daqiiqo ee hore ee nolosha ilmaha. Tani waxay dhacdaa xilliga dhalmada, haddii hooyooyinka siilka waxaa ku nool la jeermiga. Sidoo kale waxaa jira warar sheegayay in C.Albicans galo jirka ilmaha weli waa in marxaladda embriyaha, maxaa yeelay, likaha ayaa dhowr jeer lagu helay in dheecaanka amniotic. Haddii naag foolanaysa oo kale oo qayb ka ah boqolkiiba yar oo dad ah kuwaas oo aan sidayaal likaha waa, ilmaheeda inta lagu guda jiro sano ee hore ee nolosha iyaga ka heli kartaa iyada oo ibta naaska, alaabta lagu ciyaaro iyo wixii la mid ah. Argagaxa sababtoo ah tani ma aha lagama maarmaan, maxaa yeelay, Candida, mar jirka ah ee ay martida u, aamusnaan ah u dhaqmaan, xataa caawin isagii, xakameeyo koritaanka wareer kale.

Marka cudurka fangaska Candida uu noqdo cudur

Qofka noqon karo side jeermiska nolosha halka gebi ahaanba caafimaad qaba. Fungi of panulirus ah Candida noqon pathogenic kaliya marka ay soo batay waxaa gacanta ka baxa. sababaha:

- uurka;

- cudurada kala duwan;

- daridda cudurada raaga,

- hypothyroidism ama vitamin deficiency;

- daaweyn muddo dheer oo la isticmaalayo antibiyootiko,

- corticosteroids;

- cudurada hormoon.

Sababta ugu weyn ee sababa candidiasis, difaac yar yahay. Xaaladani waxay dhici kartaa xaalado badan, oo ay ku jiraan nafaqo xumo, xaaladaha nololeed ee liita, stress joogto ah.

Intaa waxaa dheer, koritaanka degdeg ah fangaska Candida wuxuu dhacaa marka cudurada saameen soo socda:

- AIDS (ama caabuqa HIV);

- diabetes;

- qaaxada;

- cudurada caloosha,

- cudurada of nidaamka genitourinary;

- hypothyroidism,

- cudurada dhiiga Qaar ka mid ah;

- Vaginosis.

arrimaha pathogenicity

Cabirka of panulirus fungus Candida waa microns kaliya 2-5, si ay u la oran karo waa microscope ah oo kaliya ka yar. Kuwa plenochki caddaan ama hurdi-ciiro in koraan on Haagaar ama huurada in la arki karo oo ku saabsan meelaha ay saameeyeen ee jirka - taasi waa deegaanada oo dhan fangaska, tirintii boqolaal kun oo sheyga shaqsi. Marka u shaqeeyo ciidanka, dhaqanka oo ka mid ah fangaska ee panulirus ah Candida? Microbiologists daraasadda muujisay in likaha walba ku dadaaleysaa in ay horumariyaan Amda, in uu yahay, meel u dhow yihiin in, mid la odhan kara, koraan galay unugyada aadanaha. Waxaa microbes maareeyo fudud hoose waxay leeyihiin xasaanad la mid ah dhibanayaasha ay ka, iyo sare cudurada hormoonada jidhka iyada. qaybta ugu firfircoon ee ku xajin likaha noocyada C.Albicans. Marka on the xub-axaleedka, waxaa dhaqmayso in 100% ee kiisaska. Inta badan noocyada likaha dadban C.Krusei. Wuxuu laga yaabaa in aan la hagaajin, ka dibna waxaa jira ma jirin cudur. Caawinta fangaska gelin borotiinada dusha iyo borotiinada dusha, taagoo qaar ka mid ah, tus, polysaccharides iyo glycoproteins, oo u taagoo ee candhuufta afka. Guud ahaan, Candida waa glikogenofilami (glycogen sida), inta badan colonizes unugyada meesha waxa ku jira dad badan, tus, xabka siilka iyo saabka afka. Haddii ay dhacdo in fangaska khamiir of panulirus ah Candida in smear ah laga soo qaatay xubnaha kuwaas oo shaaca ka qaaday itimaalka sare oo awood cudurka baadi-free.

Marka marxaladdan hore ee fangaska Amda yihiin foomka khamiir, laakiin si dhakhso ah habeyn, sameynta filaments dheer (hyphae), kuwaas oo si fudud loo geli galay unugyada ciidanka u burburay iyo phagocytosis of leukocytes nugul yar.

Adkaynta iyo odayga, dulin inta ay nolosha ku shaqeeyo ciidanka go'doonsan sunta kala duwan:

- kandidotoksin (falalka protein on basophils iyo unugyada waaweyn oo keenaya dacayadeed-jawaab);

- 6 nooc oo miisaan ku yar sunta kelli (permeability vascular kordhay, cadaadis dhiig oo hooseeya);

- sunta la egyahay (Diintiisa leukocyte reactions maxalliga ah iyo mid horseeda in muuqaalka kore ee unugyada granulation).

Candidiasis carruurta

Sida kor ku xusan, dhallaanka qaba Candida midkood uurka ama dhalmada inta lagu guda jiro marinka ee marinka dhalmada. In mustaqbalka, fungus ka heli kartaa ilmaha afka la mujuruqa liidata loola dhaqmo, gilgilay, la caaggaas hooyadeed cudurka. Calaamadaha in ilmahaaga uu qandaraas cabeebka, kuwa soo socda:

- caddaan, aqalada daahan cheese-sida on carrabka, on desenok dusha hoose iyo dhabanada,

- moodiness;

- diidmada oo cunto ah.

Haddii aan la daweyn, fungus sii si ay u degaan iyo ugu dhakhsaha badan u muuqataa on bushimaha ilmaha.

Fungi of panulirus ah Candida mindhicirka dysbiosis calaamado cad sida:

- shuban;

- feejignaan xumo;

- heerkulka,

- khasaare ah oo miisaankeedu yahay.

Shuban carruurta waa khatar, sababtoo ah waxaa ay keenaysaa in fuuq-bax degdeg ah, sidaas darteed ilmo buka in lagu isbitaal. Kaliya ee isbitaalka isaga siin karaan daaweynta lagama maarmaanka ah (faleebo) si looga hortago khasaaro dheecaanka.

Waxa intaa dheer in mareenka caloosha iyo mindhicirka iyo saabka afka, cabeebka ee ilmaha ayaa laga yaabaa inuu maqaarka. Xaaladdan oo kale, waxaa jira ma cad yihiin, iyo baro casaan ah sida finanka xafaayadda. Ilmuhu wuxuu noqonayaa mid aad u cadho sida wax erosions taabashada isaga qaba. Inta badan, candidiasis cutaneous in dhallaanka u muuqataa in laalaabka on lugaha, barida iyo gumaarka. Hormarey finanka xafaayadda ka, isagoo xafaayad aad u dheer, nadaafad xumo iyo aan habboonayn (dardaro, aad u dhagan) dharka.

Daaweynta candidiasis carruurta

Haddii fangaska ee panulirus Candida habka pathogenic bilaabay afka ilmaha, daaweynta waxaa sida caadiga ah ku qaadeen degaanka. Waxay ka kooban tahay in howsha meelaha ay jirto film cad, diyaarinta gaar ah. Markii hore, dhakhaatiirta loo aaneeyey inay u dufan afka ilmaha la rinjiga cagaaran. Daawadan waa mid aad u wanaagsan, laakiin qalalan-axaleedka. Haddaba isticmaalaan "Akriderm", "Fukortsin" Xalka of borax in glycerine ah.

Sida ka hortaga waxaa lagama maarmaan ah in bilood ee ugu horreeya ee nolosha karkariyo grudnichka ibta iyo dhalooyinka, ku dhaq gilgilashada. Hooyo waa in ay la tacaalaan ka hor inta ibta quudinta daroogada antifungal.

Marka calaamadaha saxarada pass dysbiosis grudnichka on bakposev. Waxaa la rumeysan yahay in fangaska ah panulirus Candida ee saxarada carruurta da'doodu ka yar tahay 12 bilood la joogo in tiro aan ka badnayn 103KOE / g laga yaabaa in, iyo in ka badan 12 bilood ee qadarka 104KOE / g. Haddii qiimaha la dhaafo, daawo in loo soo celiyo flora iyo xoojinta habka difaaca jirka.

nystatin, levorinovoy - Marka maqaarka candidiasis goobaha saliidda antifungal lahu saameeyeen. Aad u faa'iido badan inay ku maydhato ilmaha biyihii ku dhex leh waxaa dheer ee isku xigta maraq, marigold, chamomile. All maryaha iyo xafaayad u baahan tahay inaad bir ah, iyo in la beddelo xafaayadda badanaa ku filan, ma sugayaan iyaga si ay u buuxiyaan buuxintii.

Haddii daawooyinkaan kuma caawin, ilmahaagu qaataan baaritaan dheeraad ah iyo qori therapy antifungal.

Candidiasis in ragga iyo dumarka

In dadka waaweyn, fangaska Candida karaan, sida carruurta, si ay u qaadsiin afka, maqaarka iyo mindhicirrada. Candidiasis lagu muujiyey afka xiriiri caseous ah, carrabka xiiso leh, ciridka, dhanxanegga, dhabannada, iyo dhinaca hoose oo ay la socdaan dareenka daran. Mararka qaarkood dilaaco-axaleedka. Candidiasis maqaarka lagu gartaa baro casaan ah meelo ka mid ah hordhaca ah ee fangaska (kilkilooyinka, naasaha dumarka ka yar, qanjidhka, ugu yaraan hoos jilbaha). dhibco Kuwani cuncun iyo diirka, halka xoqidda-dilaaco. Laakiin inta badan dadka waaweyn oo dhan ku silco oo ka xubnaha kaadida candida. Haweenka fangaska ku hoydaan siilka iyo siilka, si cudurka waxaa la yiraahdaa vulvovaginitis. calaamadaha ay ku jira marxaladaha bilowga ah sida soo socota:

- cad (sida caanaha dhanaan) Dheecaan siilka;

- cuncun, ma marayay, laakiin on lid ku ah, ka dib markii lagu nadiifiyo koraya iyo subaxdii;

- nigis ur xun;

- Xanuun xilliga galmada.

The calaamad ugu sheegistii - fangaska ee panulirus ah Candida in smear ah laga qaaday xubinta taranka.

Haddii aan la daweyn, calaamado ka xun yihiin. , Xanuun ma aha oo kaliya inta lagu jiro galmada, laakiin sidoo kale ee kaadi kasta, bararto xabka siilka, dilaaco, dheecaan ayaa noqonaya sii dhumuc weyn.

In ragga, cudurka waxaa la yiraahdaa balanoposthitis Candida. calaamadaha:

- qoondaynta of nooca cheesy ee xubnaha galmada,

- cuncun, xanuun marka la kaadinayo,

- galmo daran.

Waxa intaa dheer in nidaamka genitourinary, fangaska Candida waa dulin on meydadka sare ee dadka. cudurka dhidib loo yaqaan "galbanum" iyo rullaluistemadka prinogtevogo - "paronychia". Sababaha cudurada u noqon karaan hangnail ah, fulinteeda ah alaabtii lugaha in cudurka.

Falanqaynta on the fangaska ee panulirus ah Candida

Candidiasis ayaa qarka u saaran ku salaysan natiijooyinka daraasaadka kuwan:

- smear ka saabka afka ama siilka;

- beeridda,

- ELISA,

- PCR.

Intaa waxaa dheer, waxaa laga yaabaa in uu dhakhtarku kugu amro baaritaan kaadida iyo dhiiga.

Haddii aad qorsheyneysid inaad qaado suuf ka siilka iyo / ama kaadi mareenka, looma oggola inaad ku maydhaa, laakiin kaadi karaa oo kaliya 2 saacadood ka hor qaadashada smear ah, aan ka dambayn. Haddii aad qorsheyneysid inaad qaado suuf afka ka, waxaa mamnuuc ah in la nadiifiyo ilkaha.

Waayo, beero isticmaalka saxarada, candhuufta, kaadida, xago ka aagaga dhibaateysan ee maqaarka iyo xub-axaleedka. Saddex maalmood dabadeed, hesho jawaab, haa ama maya ee wax ka mid ah fangaska ee panulirus ah Candida. Norm - waa negative. Haddii baaritaan xaqiijiyo joogitaanka of fungus ka, loo ogaado in ay yihiin nooca iyo dareen in daawooyinka.

Falanqaynta ELISA waxaa lagu magacaabaa immunoassay enzyme. Waxay ka caawisaa si ay u aqoonsadaan antibodies in fungus iyo track, dhaq-geedi socodka. cilmi Waxyaabaha for EIA waa dhiig ka xididka. Guud ahaan, waxaa la fuliyay in lala bakposeve.

Waxaa loo arkaa falanqaynta PCR ugu sax ah waxa ay ka dhigan tahay in ay dareen-celin polymer-silsilad ah u taagoo DNA of fungus ka. Waxaa lagu ogaadaa joogitaanka pathogene xitaa bilowga hore ee cudurka. Qoraalkani wuxuu ku for PCR waa Digo xaako, dhiig.

daaweynta

Haddii bukaanka waxaa laga helaa fangaska ee panulirus Candida ah, daaweynta waa daawo. qorayaan Inside:

- "fluconazole".

- "Nizoral".

- "Diflucan".

Oo dibadda loo isticmaalo cadar:

- "clotrimazole".

- "Sertokanazol".

- "Miconazole".

- Shumacyada leh pumafitsinom iyo siyaabo kale oo la xakameeyo koritaanka of fungus. Waxay waxaa lagu qori karaa oo cadar antiinflammatory.

Daaweynta haweenka uurka leh waa la fuliyay oo keliya macnaha dibadda. Kaliya in a kiisas yar loo qoondeeyey "Pumafitsin" afka.

Marka mareenka Fistula candidiasis waa daaweynta ee labada lamaane galmo.

Waxa intaa dheer in daawooyinka antifungal jira vitamins qoray iyo siyaabo kale oo, u taageeraan nidaamka difaaca jirka.