"Finoptinum": tilmaamaha loo isticmaalo, halabuurka, dhigooda dhabta ah

Laga soo bilaabo wadnaha iyo cudurka dhuumaha ugu saameeya dad badan. Waxaa intaa dheer, da'da, khatarta ah in dalalka cudurka sida waxa si wayn u kordhay. Si loo yareeyo khatarta ka mid ah geedi socodka daran ee jirka ku jira, dhakhaatiirta ku talinaynaa isticmaalka qalab gaar ah. iyaga ka mid ah ayaa si gaar ah caan yihiin blockers channel calcium. Waa koox Nuurre Aw daroogada. Waxa ay qaab hawleed waxa uu la xidhiidhaa awood u leh inay la xakameeyo wax lays ee udhigo calcium ka bannaan ee extracellular in unugyada iyo xididdada dhiigga ee wadnaha. Yaraynta fiirsashada ah ah walxahaasi, medicament ku fulyo tallaabo vasodilating.

Daawada ugu waxtarka badan leh guryaha oo kale waa "finoptinum". Tilmaamaha loogu isticmaalo ee halabuurka ah, analogs, tilmaamo loogu isticmaalo daroogada iyo saameynta dhinaca ay halkan ku tilmaamay.

Form, halabuurka

Waa maxay qaab caan ku yahay daroogada "finoptinum"? Tilmaamaha on codsiga ayaa sheegay in waxa laga iibsan karaa sida irbad iyo kiniiniga.

Sida qayb firfircoon ee wakiilka this dhaqmo hydrochloride verapamil. Sidoo kale in diyaarinta waxaa ka mid ah isku xirnaanta kaabayaal kala duwan (ku xiran tahay noocyada sii daayo).

saamaynta pharmacological

Waa maxay astaamaha yihiin asalka ah ee daroogada "finoptinum"? Tilmaamaha loogu isticmaalo, dib u eegista sheegan waa xanibaha calcium channel ah (xulashada) heerka koowaad. Waa difenilalkilamina a derivative iyo muujinayaa antianginal, antihypertensive iyo ficil antiarrhythmic.

saamayn Antianginal daroogada this la xiriira awooddiisa ah inuu saameyn ku myocardium iyo hemodynamics durugsan. In si kale loo dhigo, daroogada yaraynaysaa midab ee halbowlayaasha. Intaa waxaa dheer, waxa ay yaraynaysaa tamarta ATP transformatsiiyu in ku jira xiriirka-tamar sare shaqo farsamo iyo yaraynaysaa contractility myocardial.

Sidoo kale waa in Waxaan la soco in isticmaalka daroogada this si weyn u yaraynaysaa myocardial O2 oo uu leeyahay chronotropic negative ah, inotropic iyo saamaynta vasodilatory.

sifooyinka daroogada

Sababtoo ah halka ay ka kooban, medicament "finoptinum" ah, analogues ah kuwaas oo hoos ku qoran, cabudhibayo automaticity ee Guntin Dalqada wadnaha yaraynaysaa AV-tabinta iyo kordhiyaa mudada madax adkaadeen.

Kordhinta jeer nasashada ventricle diastolic (bidix), daroogada this yaraynaysaa derbiga tonus myocardial ah, i.e. waa hab kaabayaal lagu daweeyo cardiomyopathy hypertrophic obstructive.

Sidoo kale waa in la ogaadaa in daawo loo arkaa muujinaysaa guryaha anti-arrhythmic la garaaca supraventricular.

The kinetics daroogada

Diyaarinta "finoptinum" barashada taas oo hoos ku qeexan, waxaa lagu nuugo ka soo mareenka dheefshiidka (ku dhowaad 90% qiyaasta). Its ururka la protein ah waa 90%.

Daawada waxaa metabolized ee marinka (hore) iyada oo beerka. Tani foomamka derivative noocan oo kale ah sida norverapamil in waa hawl hypotensive ka yar verapamil unmodified.

Markii ugu bar-nolosha ee daroogada Marka la helo hal qiyaasta waa 3-8 saacadood. At isticmaalka qiyaasood oo soo noqnoqda ee medicament, tiradaasi kala duwan (5-12 saacadood).

Dheefay daroogada iyada oo mindhicirrada iyo kelyaha.

maragga

Xaaladaha qaarkood, qoro dawooyinka "finoptinum"? Tilmaamaha loogu isticmaalo (kiniin iyo xal isku duro waxay leeyihiin isku showy) dhigayaa in qalab this waxaa loo isticmaali karaa tachycardia supraventricular (oo ay ku jiraan paroxysmal, syndrome Lown-Ganong-Levine iyo WPW-syndrome), stroke (danab, deggan oo aan vasoconstriction, vasospastic deggan), tachycardia sanka, flutter wadne, tachyarrhythmia wadne, arrhythmia wadne, dhibaatooyinka hypertensive (maamulka gale), hypertension, hypertension lagama maarmaan ah in hvs yar in wareegga, cardiomyopathy obstructive hypertrophic.

sababo

Marka aan si loo maamulo "finoptinum"? Tilmaamaha loogu isticmaalo (irbado iyo kiniinno leeyihiin sababo la mid ah) waxay muujinaysaa in qalab this waa mamnuuc in loo isticmaalo in hypotension daran, sinoatrial sanka buka syndrome (marka laga reebo in bukaanka qaba pacemaker a), AV-Go'doominta ah syndrome saddexaad iyo labaad-degree Launa hareereeyey iyo -Ganonga-Levin iyo-WPW syndrome isku dhafan oo wadne ama flutter wadne, uurka, diidmo in verapamil, naas-nuujinta (dadka buka la pacemaker ah marka laga reebo).

Drug "finoptinum": tilmaamaha loo isticmaalo

qiyaasta of daroogada waxaa loo xisaabiyaa dhakhtar gaar ah.

bukaanka kiniin Adult waxaa maamula afka ee dose hore ee 40-80 mg saddex jeer maalintii. Waayo, foomamka qiyaasta hal qiyaasta a sii daayo joogto ah waa in la kordhiyaa, iyo inta jeer ee maamulka - hoose.

Kids da'doodu tahay 6-14 sano, dawadan waxaa lagu talinayaa in ay qaataan in xaddiga 80-360 mg maalintii, iyo ilaa 6 sano - at dose oo ah 40-60 mg maalintii. Inta jeer ee maamulka daroogada waa afar jeer maalintii.

Haddii loo baahdo, daroogada in su'aal la intravenously (si tartiib ah) duri karo. Sayidka waxaa lagama maarmaan ah in lala socdo ECG, cadaadiska dhiigga iyo garaaca wadnaha ee bukaanka ah.

qiyaasta xal la tuuro aadanaha ee dadka waaweyn waa 5.10 mg. Haddii saamaynta ku daweynta maqan yahay, markaa ka dib 20 daqiiqo of diyaarinta la dib-u-gelin karaa (at dose oo isku mid).

qiyaasta hal foom A mudo oo daroogada ah ee carruurta 6-14 sano jir waa 2.5-3.5 mg ee caruurta 1-5 sano - 2-3 mg, iyo ilmaha ilaa hal sano - 0.75-2 mg.

Bukaanka qaba beerka daran dose maalin walba waa in aan ka badnayn 120 mg.

qiyaasta ugu badan ee diyaarinta afka ah maalin kasta waa 480 mg.

waxyeellooyin

Diyaarinta "finoptinum" cadhaysiinina kartaa soo socda reactions dhinaca:

• miisaanka oo kordha, bradycardia, Agranulocytosis, ama sii xumaanaysa wadnaha, hyperprolactinemia, tachycardia, khasaaraha transient aragtida, barar durugsan;
• hoos u calaamadeysan dhiig karka, gynecomastia, galactorrhea, arthritis, angina, arrhythmia, barar sambabada, AV-block of heerka saddexaad, asystole, Torombositobiiniya astaamo, burburkii;
• lalabo, qallafsanaan gacmaha ama lugaha, kelyaha ciridka, suuxid, daal, korodhsan xumo, walwal, korodhsan transaminases beerka;
• finan maqaarka ah, dawakhaad, calool engeg ama shuban, madax xanuun, niyad-jabka, suuxin, xanuunada extrapyramidal, daal, bafinayo ee maqaarka, ka hurdo, multiforme erythema exudative, pruritus.

isdhexgalka daroogada

waxaa suurtagal ah in lagu biiriyo daawooyinka daawo kale "finoptinum"? Tilmaamaha on codsiga sheegayaa in isku darka oo ka mid ah wakiilada la daroogada antihypertensive wadajir xoojineysaa ay saamayn antihypertensive.

By maamulka xididka of verapamil dadka dhawaan helay qiyaas beta-blockers, waxaa jira halis sare oo hypotension (halbowlayaasha) iyo asystole.

Marka co-maamula "finoptinum" daroogada la beta-blockers, daawada suuxinta neefsasho iyo daroogada antiarrhythmic kordhisaa halista wadnaha, bradycardia, hypotension daran iyo AV-go'doominta.

Wada jir ah ula gelitaanka "Amiodarone" ayuu bradycardia maqalka, saamayn inotropic negative, AV-block iyo rabshooyin tabinta.

Maxaa yeelay, verapamil hakiyo CYP3A4 isozyme, ku lug-shiid ee dawo, lovastatin iyo atorvastatin laga yaabaa in daliilka dhexgalka qaar ka mid ah in waxa sababa kordhaya uruureen of statins ee dhiigga. xaaladood oo rhabdomyolysis kale oo ay leeyihiin.

guryaha antianginal "finoptinum" maqalka marka la isku daro Nitrate.

Wada jir ah ula gelitaanka ee acetylsalicylic acid waxaa kordhay waqtiga dhiig ay sabab u tahay tallaabo antiplatelet daro.

Ma qaadan karaa "Dizopiramid" si wadajir ah ula daroogada "finoptinum"? Tilmaamaha loogu isticmaalo ayaa sheegay in isku darka this keeni karta in hypotension daran iyo burburkii, gaar ahaan dadka qaba wadnaha decompensated ama cardiomyopathy.

Marka la isticmaalayo labada looxyadii iyo xal kordhisaa-fiirsashada ee dhiigga leh "imipramine", ku dheehan halista ah ee isbedel la rabin on ECG. Sidoo kale waa in la ogaadaa in verapamil kordhiyaa bioavailability ee "Imipramine", yaraynta ay ansixin.

Iyada oo isku dhafan ee daroogada la "carbamazepine" tallaabo sare ee dambaysta ah, iyo sidoo kale kordhisaa halista waxyeellooyinka ka yimaada habdhiska dhimirka.

Isla mar ahaantaana qaadashada daroogada la "clonidine" waxaa jira kiisas of wadnaha ee dadka qaba dhiig-karka.

Marka isku medicament la daliilka carbonate lithium ee isdhexgalka daroogada waa la saadaalin karin iyo isku qasan. Waxaa jira xaalado ah neurotoxicity, bradycardia daran, kor loogu qaado saamaynta lithium iyo yaraynta ee ay fiirsashada ee dhiigga.

Sida falimihiisii kale "Rifampicin" on daroogada "finoptinum"? dalalka Buugga in isku darka this xaadiriyaan ensaymes beerka, sare u shiid of verapamil. Tani waxay ugu dambeyntii keenta in hoos u dhac ku waxtarka caafimaad ee daawada hoos tixgelin.

talooyin gaar ah

Waxyaabaha aad ogaanaysid hor inta aadan isticmaalin daawada "finoptinum" (40 mg)? Guide ayaa sheegay in qalab this waxaa loo isticmaalaa si taxadir leh markii AV-Go'doominta oo ahaa darajadii ugu horeysay, stenosis aortic daran, bradycardia, Wadnaxanuun myocardial la joogitaanka ventricular bidix failure, gabsiiya wadnaha dabiiciga ah ee joogtada ah, hypotension dhexdhexaad ah ama sahlan, cagaarshowga ahaan ama kelyaha. Sidoo kale si taxadar leh dawadan waxaa lagu talinayaa in dadka waayeelka ah iyo caruurta yar yar.

In ba'an loo qaadan baahan baxay by therapy isku dhafan ee hypertension iyo angina by verapamil iyo beta-blockers. Laakiin waxaa lagama maarmaan ah si looga fogaado in maamulka xididka doonana.

Marka dhaweynta of taasi ka dhigan tahay waxaa laga yaabaa in bukaan-socodka horumarinta reactions sida shakhsiga ah sida hurdo ama dawakh, taas oo saamayn ku yeelan kara awooda qofka uu ku sameeyo shaqo halis ah.

Uurka iyo nuujinta

Haddii ay suurto gal ah hooyooyinka cusub mustaqbalka qoray daawada "finoptinum"? Tilmaamaha loogu isticmaalo inta ay uurka leedahay waxa uu leeyahay in ay tani ka dhigan tahay saamayn xun ku saabsan horumarinta uurjiifka. Waxa kale oo ay ag maraaba caanaha naaska. Sidaa darteed, hoos jira xaalad kuwaas oo daroogada si adag ahaan uu u.

Medicament "finoptinum": dhigooda iyo kharashka

Qiimaha qalab this waxaa laga yaabaa kala duwan. Sida caadiga ah, waxay ku xiran tahay qaab la sii daayo daroogada, oo ay tiro ama baaxadda. Celceliska qiimaha "finoptinum" waa 100-170 rubles.

Haddii loo arko daroogada aad yihiin, waxaa lagu beddeli karaa by mid ka mid ah hab soo socda: "Verapamil", "Verogalid" "Verapamil-OBL", "Kaveri", "Verapamil Sopharma", "Verapamil-kolay yar," "Verapamil-Verein" "verapamil-ratiopharm" "Isoptin", "verapamil-Escom," "Vero verapamil," "hydrochloride verapamil" "Lekoptin".

Reviews of dhakhaatiirta iyo macaamiisha

Khubarada ayaa sheegaya in kiniinada iyo xal "finoptinum" waa wax ku ool ah oo aan qaali ahayn hab, kuwaas oo loogu talagalay in lagu soo celiyo cadaadiska dhiigga, iyo in la wanaajiyo ladnaanta ee cudurrada kale ee wadnaha iyo xididada dhiiga.

Sida bukaanka, Badankoodna waa arrin ku qanacsanayn natiijada daaweynta wakiilka this. Kiniinka ama xal galiyey xididka fududeeyaa reebay deg deg ah ee calaamadaha hypertension iyo calaamadaha kale ee cudurka nidaamka wadnaha.

Sidoo kale waa in Waxaan la soco in oo ku saabsan daroogada oo waxay heleen warar xun. Waxay ku hadlaan mid ah tiro badan oo ah falcelin kooxda in si degdeg ah ay dhacaan ka dib markii la isticmaalayo daroogada. Sidoo kale, dadka isticmaala badan ka caban ku saabsan sababo badan.