Kiniinka "Nimesulide". Tilmaamaha loogu isticmaalo, dhigooda dhabta ah

Xanuun - waa nooc ka mid ah isku day oo jidhka ah si loo soo jiito dareenka qofka, wac caawimo. Sidaas qalad in ay wax "boqortooyada deenishka", iyo khayraadka ee jirka kuma filna si uu u xaliyo dhibaatada, waxaan u baahan nahay taageero ka baxsan.

Consumer suuqa dawooyinka ee Federation Ruush soo bandhigay boqolaal daawooyin si loo caawiyo dadka ay ula qabsadaan xanuunka. Dhamaan daawooyinka ka kooban oo kala duwan, baaxadda iyo hab wax raadeeya. Mid ka mid ah kuwa ugu waxtarka badan yihiin daawooyinka ka tirsan ee daawooyinka ka hortaga bararka non-steroidal. iyaga ka mid ah waa ganaax iyo kiniiniyada "Nimesulide".

Qaab dhismeedka iyo Curiska

kiniiniyada Round leeyihiin qaab a lenticular. In color laga yaabaa in midab jaalle midab huruud ah ama si fudud. The qayb weyn ee firfircoon - walax Nimesulide ku jirta kiniin kasta - 100 mg. Laga soo bilaabo tiro la odhan karaa waa cellulose dheeraad ah mikrokristallin, istaarijka (gallayda), sodium glycolate noqde, Kolloidol Silicon dioxide.

Intaa waxaa dheer, daroogada waxaa la siiyaa macaamiisha ee foomka of budo la joojiyo "Nimesulide." Curiska waa isku mid sida in ka mid ah kiniin, 100 mg guntin kasta qayb weyn ee firfircoon.

pharmacodynamics

Nimesulide eegista hakiyo cyclooxygenase-2, cyclooxygenase-1, saamaynteeda waa ilaa xad aad uga hooseeya. Marka tan la eego, Iscelin of prostaglandins Avv arkay xanaajiyeen reaction bararka. Si kastaba ha ahaatee, formation of nooca-prostaglandin nimesulide sharciyeed fulyo saamayn kali ah la geran karo, taasoo keentay in daliilka rahaamad yar ee nidaamka dheefshiidka.

Intaa waxaa dheer, tallaabada ku ool ah oo nimesulide muujiyey in Iscelin of formation of xagjirka lacag la'aan. Si kastaba ha ahaatee, habka of hemostasis iyo phagocytosis uusan u oggolaan saamaynta walax this. farsamo ee medicament saamayn anti-bararka iyo cunfiga degan meel badan oo ay awoodda si loo xakameeyo sii daayo myeloperoxidase (in cuduro badan oo bararka waxay keeni kartaa dhaawac jirka, waa mid ka mid ah sifooyinka ugu sax ah ogaanshaha muujinaysaa khatarta ka iman karta wadno ama stroke).

Tilmaamayaasha loo isticmaalo

Wide baaxadda ku filan oo ah daawada "Nimesulide". On waxa ay ka dhigeysaa daroogada this? Maxaa yeelay, daroogada ayaa saamayn adag aadanaha - antioxidant, xanuunka, qandhada iyo anti - ka dibna waxaa loo xilsaaray la tiro ka mid ah cudurada bararka. daroogada ku ool ah oo ay goobjoog ka ahaayeen osteoarthritis (cudur si wadajir ah chronic in meesha ugu horeysa waa la wada baabbi'iyey carjawda articular), soo kacay (caabuq seed iyo xumaanshaha tissue), bursitis (caabuq of bacaha-axaleedka, ahaaday ee laabatooyinka).

natiijo wanaagsan ayaa muujinaya "nimesulide" ee daaweynta ee rheumatoid arthritis, cudurada rheumatic dheeri ah articular. Si guul ah dagaalka ka dhanka ah cudurada faafa in ay la socdaan geedi socodka bararka. Marar badan, "Nimesulide" kiniin loo isticmaalo cudurada, daaweynta dhaawacyo kala duwan ka soo jeedo. Bukaan-socodka odhan tirtiridda ku ool ah oo xanuun inta lagu jiro baxnaaninta postoperative.

Sababo "nimesulide"

Tan iyo medicament ah loola jeedaa koox shirka Square National casriga ah, waxa ay leedahay xad liiska dheer ee sababo. "Nimesulide" (waxa ka caawisaa daawada - hore ayaa looga hadlay) waa in aanay qaadan dadka qaba diidmo qayb kasta ee ay ka kooban. No daroogada ay maamusho in bukaanka qaba taariikh kuwa muuqan reactions hepatotoxic iyo jawaab diidmo sida rhinitt, bronchospasm, urtikaria (la aspirin ama wakiillo kale NSAIDs kooxda).

Sababo isticmaalka medicament waa in la qabto wax lesions erosive-qoon leh ee nidaamka dheefshiidka, u janjeera in ay horumariyaan dhiig kasta oo asal ahaan (t. Isbadalka E. dhaxgalka ee xinjirta dhiigga).

Daawo "Nimesulide" edbinta mamnuucayaa bukaanka qaba kelyaha, cagaarshowga, kaafi wadnaha. Bukaanka qaba "aspirin" asthma, khamriga iyo ku tiirsanaanta maandooriyaha iyo ha qaadan daroogada.

Ha qoro dawooyinka xaaladaha kuwa, haddii bukaanku u korodho heerkulka jidhka ama calaamado kale hargabka oo kale ayaa la arkay. Intaa waxaa dheer, waxa aan la aqbali karin in ay qaataan caruurta "Nimesulide", uurka leh iyo dumarka nuujinaya.

reactions dhinaca macquulka ah "nimesulide"

Codsiga of medicament waxay keeni kartaa dhowr ah oo waxyeelo ka soo xubnaha qabadyo iyo habab ee jirka aadanaha.

Badanaa falcelisyada ugu badan laga diiwaangeliyey by ee habka dheef shiidka, iyo waxay muujiyey by lallabo, matag, shuban, yaaqyaaqsi, iyo horumarinta gastritis. In ka yar inta badan ka dhacaan dhiig iyo mindhicirka, boogaha ilaa daloolin. Mararka qaarkood waxaad maqli karo oo ku saabsan dyspepsia, stomatitis, calool xanuun.

waxay keeni kartaa "nimesulide" tallaabo dhinaca by nidaamka hepatobiliary, inta badan muujiyey kor u kacay heerka enzyme beerka, ugu yaraan - horumarinta hepatitis (oo ay ku jiraan fulminant ..), joonis Cholestatic.

On dareen-celinta nidaamka wadnaha dhihi karaa, haddii ay jirto kor u joogto in cadaadiska dhiigga, waa dhif in bukaanku ka walwalsan wadno, hemorrhage, bafinayo, cadaadiska dhiigga ka bootin.

nidaamka Urinary jawaabi karaan muuqaalka kore ee barar (ma aha inta badan), dhif - kaadi haynta, hematuria, gubta. Aad u dhif ah waxaa laga yaabaa in kelyaha, kelyo xanuun interstitial, oliguria.

reactions suurtogalka ah ee yimaada habdhiska dhimirka waxaa inta badan ku muujiyey by wareer, qidmeyntiibulshada, asthenia. In ka yar inta badan waa la maqli karaa oo ku saabsan madax xanuun, horumarinta somnolence (la mid ah hypnotic hurdada), Reye ee syndrome (encephalopathy), hypothermia (jidhka oo hoos u heer-kulka ka hooseysa heerka loo baahan yahay si ay u ilaaliyaan shiid caadi ah). Mararka qaarkood waxaad maqli karo oo ku saabsan falcelinta sida "Nimesulide", sida isku yaacsanaan, walaaca, qarow.

Iyadoo la tixgelinayo nidaamka durey iyo nidaamka hematopoietic ah, "Nimesulide" (Instruction, gargaarka degdegga ah dib u eegista xaqiijiyo macluumaadkan) waxaa laga yaabaa in marar dhif ah ka cadhaysiinina anemia, eosinophilia, weli yar tahay in ay horumariyaan pantsitopenicheskaya purpura Torombositobiiniya.

Marar dhif ah, laakiin waxa aad maqli kartaa oo ku saabsan rabshooyin dheefshiidka (hyperkalemia), habka difaaca (elerji, anaphylaxis), xubnaha muujinta (Aragga oo isku darsamay, aleelka of beeraha), neefsashada, mediastinum (weeraro dyspnea, bronchospasm, asthma). Waxaa jiray dareen diidmo oo ka mid ah maqaarka iyo unugyada subcutaneous (dhidid, cuncun, dermatitis, urtikaria, erythema, aad u dhif ah - sun necrolysis epidermal, Stevens-Johnson syndrome).

kacmaha iyo circuit codsiga mode

kiniiniyada Adult bukaanka "nimesulide" lagula talinayaa in ay qaataan hal mar (100 mg) laba jeer maalintii. Waxaa la doorbidaa in sidaas la sameeyo cuntada ka dib, oo wax cab biyo fara badan, waayo, daawo ah. Haddii ay tahay budada ah ganaax, ka dibna ka kooban hal bacda waxaa la badhxay in 100 ml oo biyo ah. Caruurta qaangaarka ahi in ka badan 12 sano jir ma jirto baahi loo qabo in la beddelo qiyaasta, iyo kids daroogada this si ay u helaan mamnuuc. In the case of daaweynta bukaanada waayeelka dose saxayo lama sameeyo.

Waayo, dadka ka cabanaya la'aan, cagaarshowga, ansixin creatine kala duwan ee 30-80 ml / min., Qiyaasta ma tahay mid sax ah. Haddii tilmaanta loo dhigi (30 ml / min ama ka yar.) - Reebay inaad hesho medicament.

Kuwanu waa talooyinka ugu weyn ee soo dhaweynta ah ee daroogada "Nimesulide". qiyaasta ayaa la doortay yar wax ku ool ah, oo muddo ugu gaaban suurogal, taas oo yaraynaysa khatarta ah waxyeello ka soo gaartey. Dabcan ugu badan ee therapy iyadoo la isticmaalayo "Nimesulide" kama badnaan 15 maalmood.

qiyaasta xad dhaafka ah: Astaamaha, Daaweynta

Qaadashada kiniinka "Nimesulide", waxaa lagama maarmaan ah in ay u hoggaansamaan qiyaasood oo lagu taliyey in tilmaamaha ama loo soo xushay uu dhakhtarka xaadirka ah. Is-maamulka medicament iyo (ama) isticmaalkeeda la xakamayn waxay keeni kartaa in badinta. Inta badan la arkay calaamadaha soo socda: lallabbo, matag, dhiigbaxa, mareenka caloosha iyo mindhicirka, hurdo, feejignaan xumo, hypertension (cadaadis dhiig oo sareeya), Iscelin of shaqo ee neefsashada, kelyaha ba'an.

Daaweynta ay dhacdo astaamaha badinta, waxaa taageeraya qof. nimesulide fiqiira ayaa hadda la la'yahay. Haddii tan iyo overdosing ama dose sare ah medicament aan maray in ka badan 4 saacadood, bukaanka waa isbitaalka lavage gastric dhaweynta talinayaa dhuuqda (tus, carbon firfircoonaan in xaddiga 60-100 mg dadka waaweyn ah) ah iyo noocyo ka mid ah daroogada calool jilciye osmotic.

Inta lagu jiro muddada dhan ee daaweynta waa in si taxadir leh loo socdo by xirfadlayaasha caafimaadka beerka iyo kelyaha oo shaqo. Warbixin ku saabsan suurtagalnimada of saarista nimesulide jidhka ka by kelyaha aan la heli karin. Sababta oo ah heerka sare ee daroogada ku qabanaya borotiinka diuresis qasbay ma aha wax ku ool ah.

tilmaamaha gaarka ah

"Nimesulide" si ay u bartaan qoro farmasiiyada oo aan waxaa looga baahan yahay, si kastaba ha ahaatee, waa in la qaato si taxadir leh. Iska ilaali inaad codsiga isku midka ah ee medicament iyo wax wakiilada kale ee non-steroidal anti-bararka, midiidinka analgesics. Iyadoo horumarinta calaamadaha bukaanka, dhaawaca beerka sifo (yalaalugo, matag, anorexia, kaadi madow) ama la kordhiyo heerka transaminases cagaarshowga codsiga "nimesulide" waa in la dayacay. Haddii ay jiraan qandho ama calaamado hargab oo kale ah, daaweynta waa in isla markiiba la joojiyo.

Digtoon bukaan ahaan waa in ay barbar socdaan ee "Nimesulide" daawooyinka qaadato in ay kordhiyaan halista boogaha caloosha iyo mindhicirka iyo dhiig. Taxadarka qoray daawada loogu talagalay dadka ay dhibaatadu ka ulcerös kolit ama cudurka Crohn, boogaha leh taariikh ah bukaanada waayeelka ah.

Dadka iyagu u baahan in ay qaataan "Nimesulide" oo ay la socdaan aspirin ku qaadasho wadnaha waa in loo xilsaaray therapy isku dhafan oo gastroprotectives.

Isticmaalka "Nimesulide" (ama wax kasta oo kale oo NSAID) ee u tiro badan oo muddo dheer keenaysaa in yar kordhiso halista ah ee shilalka thromboembolic (stroke, Wadnaxanuun myocardial, iyo N. sidaas on.).

Bukaanka qaba dhibaatooyin wadnaha iyo nidaamka kala duwan "Nimesulide" waxaa laga yaabaa in loo magacaabo oo keliya haddii lacagta la filayo badato khatarta waxyeellooyinka.

medicament waxa uu leeyahay saamayn ku degree hawsha xinjirowga. Macluumaadkan waxaa muhiim u ah bukaanada qaba ka diathesis hemorrhagic. lesions daran ee maqaarka inta badan loo horumariyo inta lagu guda jiro muddo dheer isticmaalka "nimesulide". Marka finanka maqaarka muuqan, uu noqonayaa dhaawac appreciable si xub-axaleedka ama wax kale daliilka go'an oo dulqaad, therapy daawada waa in la joojiyo.

Isticmaalka "Nimesulide" haweenka uurka leh waxay keeni kartaa dhow koollo halbowlaha ka hor inta loo baahan yahay, yaraynta mugga dheecaanka amniotic. khatarta laga yaabo in ay kor u ah dhiig intrauterine, itaal darro shaqada, muuqaalka kore ee barar. Sababahan awgood, hooyooyinka uurka leh inta lagu guda jiro ugu horeeyay oo trimester labaad ee soo dhaweynta uurka "Nimesulide" laguma talinayo.

Waa jawaabta su'aashan ah in aanu qaadan kartaa "Nimesulide" mar iyo khamriga, waxaa iska cad: darka noocan oo kale ah lama oggola!

analogs

Under analogs "nimesulide" waxa loola jeedaa daroogada ka soo jeeda kooxaha NSAID ay ku jiraan sida nimesulide weyn firfircoon qayb (qiimaha waayo, waxaa iyaga lagu baayici doonaa qiyaas ahaan kala duwan oo la mid ah, laakiin wax yar waxaa hoos). The analogs shaqaalaha caafimaadka ugu yaqaan oo caadi qoray waxaa ka mid ah daroogada "Naiz" (gel, kiniin, ganaax), "Nimesil" (budo) "Niemiec" (kiniin) ' "(gel, kiniin, kiniin ganaax jaqaan) nimulid .

All analogs hantidaan hufnaan ku filan oo loo xilsaaray in ay la kala duwan ee cudurrada, qof sita bararka ka qabtaan.

kala duwan oo qiimaha

Qiimaha qudhiisa for "Nimesulide" iyo analogs ay yihiin ku dhowaad isku mid ah, inkastoo aan tixgeliyo qiimaha daroogada ka badan ay heli karaan tiro balaadhan oo ah iibsada. Kiniiniga "Nimesulide" (20 kumbiyuutarada. In pack a) ku kici doona 85-90 rubles halkii pack. tiro la mid ah kiniin "Naiza" kici doonto 110-140 rubles, "Niemiec" (oo sidoo kale 20 kumbiyuutarada.) - ee 115-134 rubles. Baako "nimulid" 30 kaniiniga kharash 180-220 rubles. content The mugga of qayb weyn ee firfircoon (Nimesulide) oo dhan analogs isku mid ah - 100 mg.

Halkii xabbo oo kiniin "Nimesulide" (qiimaha ugu hooseeya) waxaa laga heli karaa, tusaale ahaan, slurry a "Naiz" kharashka 200-300 rubles 60 ml ama "nimulid" - 75-105 rubles lacagta la mid ah daroogada. Sidoo kale diyaar u ah tiro balaadhan oo ah macaamiisha lozenges "nimulid": 20 saamiyada at a qiimaha 130-155 rubles halkii pack.

Waxaa laga yaabaa in qaab ugu qaalisan ee loo sii daayo of daroogada la nimesulide sida qayb weyn - budo 'Nimesil ". 30 bacaha (package) kici doonto macaamiisha in xaddiga ka 560 si ay u 645 rubles.

Waayo, codsi la mariyo yihiin jel wax ku ool ah oo la nimesulide. Sidaas darteed, "Naiz" kici doonto 120-145 rubles for tube ka mid ah 20 g ama 215-275 rubles (50 g). Gel "nimulid" wax yar oo jaban: 115-150 rubles halkii mugga tube of '30

Gebogebadii waxaan jeclaan lahaa in la yidhaahdo soo socda. Go'aanka ah in la isticmaalo "nimesulide", analoogga kasta ama wax kasta oo NSAIDs kale waa in la qaato uu dhakhtarka xaadirka ah. xirfadle caafimaad oo keliya si fiican qiimayn kartaa darnaanta caafimaadka bukaanka ay, si ay u eegaan cudurada la xiriira oo dhan, dooran qiyaasta daawada in ay doortaan iyo horumarinta qorshaha daaweynta ah si loo yareeyo suurtagalnimada waxyeellooyinka iyo si aad u hesho natiijooyinka ugu fiican.