Prokinetics - maxay tahay? Prokinetics ee jiilka cusub: liiska

Prokinetics - maxay tahay? Meelaha dalalka CIS-yada ma jiro fikrad caadi ah oo ku saabsan waxa mukhaadaraadka lagu daro kooxdan, sidaa daraadeed qof kasta oo ka shaqeynaya gastroenterist ayaa go'aaminaya waxa ku jira liistadaan iyo waxa aan ahayn. Prokinetics - maxay tahay? Tani waxaan isku dayi doonaa inaan ogaano.

Qeexitaan iyo sharaxaad kooban

Prokinetics - waa maxay? Tani group of daroogada in kicin motility ee tube dheefshiidka iyo ka hortagtaa hirarka anastaltic.

Cudurada mareenka caloosha iyo mindhicirrada waxaa inta badan la socda gudbinta chyme ee qaybaha hoose ee tuubada mindhicirka ilaa kuwa ka sarreeya, xadgudubka marinnada burqada cuntada ama istaagida qaybta xiidmaha. Dhamaan muuqaaladani waxa ay la xiriiraan xad-gudub ku yimaada horumarka chyme ee tuubada dheef-shiidka, taas oo macnaheedu yahay in calaamadaha la saari karo iyadoo saameeya murqaha muruqyada siman ee derbiyada. Si arrintan loo sameeyo, waxaa loo baahan yahay garsoor. Waxtarkooda daaweynta waxay la xiriirtaa joojinta habka gaadiidka ion (dopamine, 5-HT4 reseptors, oo la isku daray) ama saameyn ku leh metabolism of acetylcholine. Hirgelinta saamaynta kiliinikada waxay sabab u tahay kororka qadarka acetylcholine ee isku-dhafka isdhexgalka, ama kororka wax soo saarka ee cholinesterase, taas oo kordhiya hoos u dhigista ACS, hoos u dhaca soo saarista ACH ee leh dareenka dareenka.

Dhaqan ahaan, saameynta qaadashada daawooyinka waxaa lagu muujiyaa kor u kaca ku yimaada codka wadnaha ee wadnaha, daadgureynta caloosha, udhexgalka u dhaxeeya antrum iyo duodenum, xajiin xiidmeed oo wax soo saar leh.

Kooxda koowaad ee daroogada

Prokinetics waa daroogooyinka xayiraya D2-dopamine reseptors, taas oo kicinaysa waxqabadka murqaha muruqyada ee mareenka caloosha iyo u bixinta saameyn antiemetic ah. Daawooyinkaan waxaa ka mid ah: "Metoclopramide" (jiilka hore, wakiilada - "Tserukal" iyo "Reglan"), "Bromopride", "Domperidon" (jiilka labaad), "Dimetpramid", Itopride.

Daawooyinka Prokinetics waxaa loo isticmaalaa daaweynta xanuunka 'gastroesophageal reflux disease' (GERD), YaZhDPK, xakameyn maskaxeed, xajmiga hunguriga ka dib dhaawacyada iyo natiijada horumarinta adhesions, is barbar-dhigista ka-hortagga maqaarka ee caloosha caloosha, ku xadgudubka xajmiga xayawaanka, wax soo saarka gaaska oo kordhay.

Sidoo kale prokinetics waa daroogo loo isticmaalo lallabbo iyo matagid ay keento sunta ama cunista cunista, cudurada fayruska ama bakteeriyadu, uurka ee saddexda bilood ee ugu horeeya, ficil la'aanta jidhka, shoogga madaxa, suuxdinta, shucaaca iyo kemotherabi. Waxtarka leh ee matagidda asalka udubdhexaadka ah, maadaama ayan wax saameyn ah ku lahayn dhegta dhexe iyo medulla oblongata.

Neuroleptics oo caawinaya matag

"Sulpiride" iyo "Levosulpiride", oo ah neuroleptics oo leh habdhaqan la mid ah ficil ahaan, waxay sidoo kale leeyihiin saameyn wanaagsan oo liddi ku ah antiemetic, sidaas darteed waxaa loo isticmaali karaa dhaqdhaqaaqa gaasta.

"Metoclopramide" (prokinetics): tilmaamaha isticmaalka

"Metoclopramide" waa mid si toos ah u kiciya murqaha jilicsan wuxuuna leeyahay dhammaan waxyaabaha lagama maarmaanka u ah helitaanka natiijooyinka rugta caafimaad ee muhiimka ah, hase yeeshee waxaa sabab u ah xannibaadaha xannibaadaha hematohistological waa in loo isticmaalaa taxadar. waxyeelooyinka suurogalka ah sida dabac ah muruqyada wejiga, calaamad ah "cagaha diiqu ee", protrusion jiibta carrabka, xanuunada bulbar, muruqyada dubaaxin ekrtraokulyarnyh, surkoo spasmodic, midab-dhaafka ah ee muruqyada extensor ah, Parkinson ee syndrome, somnolence, daciifnimo, tinnitus, madax xanuun, Walaaca, maqnaanshaha maskaxda.

Goorma ayay tahay mid aan loo baahnayn in la qaato prokinetics? Tilmaamaha isticmaalka sheegay in isticmaalka aan loo baahnayn in xaaladood oo diidmo in daroogada, buro of kiliyaha adrenal, xirma xiidmaha, daloolin mindhicirka oo waxaan iyaga dhiig, burooyinka prolaktinozavisimoy, qalalka iyo cudurada extrapyramidal, hoos ilaa 16 toddobaad oo uur ah ee ilmaha, inta lagu guda jiro nuujinta, carruurta 5 sano. Taxadarka waa in la qoray at ansixin la dhimay oo ah kariyaatiniin, kordhay cadaadiska dhiigga, neefta, da'doodu tahay ilaa 14 sano.

Daawada waxaa la liqaa nus saac ka hor cuntada, kaniiniga 9:00, 12:00, 15:00 iyo 18:00. Muddada daaweynta - laga bilaabo afar ilaa lix asbuuc, mararka qaarkood waa la kordhin karaa ilaa lix bilood.

Haddii foomka sii daayo uu yahay dareere, kadibna wuxuu ku duray intramuscularly ama intravenous. Dadka waaweyn iyo carruurta ka weyn 14 sano - 10 mg. Ugu badnaan hal mar - 20 mg, maalin walba - 60 mg. Waxyaabaha ku jira dhalada waxaa lagu qasi karaa xalalka isotonic ama 5% glucose.

Domperidon: tilmaamaha isticmaalka

"Domperidone" waa xayiraad badan oo ka mid ah xayawaanka dopamine, marka laga reebo ma gashto BBB, marka marka la qaado, saameynta daawada kor lagu sharxay ma horumarin. Laakiin, kordhinta dheecaanka prolactin, waxay ka dhalataa ginecomastia, galactorrhea iyo maqnaanshaha caadada. Waxaa intaa dheer, bukaannada ayaa xusay finan maqaarka, afka qalalan, shuban iyo madax xanuun.

Laguma talin dadka qaba xasaasiyadaha xasaasiyadda ee qaybaha daroogada, dhiig-baxa ka yimaada habka dheef-shiidka, xakameynta mindhicirka, prolactinoma, inta lagu jiro naas-nuujinta, illaa 5 sano jir ama ilaa 20 kg. Si taxadar leh u qaado muddada uurka, kelyaha iyo / ama beerka.

Cab labaatan daqiiqo ka hor cunto kasta 10 mg, haddii loo baahdo, waad cabi kartaa inta aadan sariirta aadin. Qiyaasta ugu sareysa ee maalintii waa 80 mg. Haddii la joogo ee daaweynta ee laabjeexa, yaraynta dheecaan ah ee casiir gastric, waxay ahaan waa ka domperidone la cabbo goonida, quud la wadaagto cunaya.

"Isticmaal": tilmaamaha isticmaalka

"Iskudhid" wuxuu isku daraa sifooyinka dopamine antagonist iyo astaamilkolinesterase blocker. Wuxuu saameeyaa nidaamka hypothalamic-pituitary-adrenal, oo kordhiya xaddiga somatostatin iyo hoos u dhaca hormoonka adrenocorticotropic. Ficil xun ayaa lagu muujiyey leukopenia, trombocytopenia, dareen-celin aan fiicneyn, hyperprolactinemia, lallabo, tremor, cagaarshow. Inta lagu jiro soo dhaweynta, waxaa lagama maarmaan ah in la kormeero xaalada dhiigga dillaacsan iyo hubi in aysan jirin wax saameyn ah.

Laguma talin in la qaado dadka qaba ciriiri degdeg ah ama gaabis ah, xiniinyaha mindhicirrada ee taariikhda, diidmada mindhicirka mindhicirka ee jirka shisheeye ama ay ka soo gaabiso dibadda, illaa lix iyo toban sano, xilliga uurka, nuujinta.

Daawada waa in la qaadaa ilaa 50 mg saddex jeer maalintii.

Argaggixisada "Acetylcholine"

Kooxdani waxaa ka mid ah:

• "Acekledin" (M-holinomimetik);
• "Physiostigmine", "Galantamine", "Tegaserod", "Prukalopride" (celiyeyaasha celiya ee cholinesterase)

Daawooyinkaan waxaa qayb ahaan loogu talagalay qafiska qafiifka ah sababtoo ah dhibaatooyinkooda daawada: saameynta isbeddelka tamarta potassium, iyo natiijada, kordhinta QT-da, taas oo keenta qalqal wadnaha wadnaha ah. Qaar ka mid ah daawooyinka ayaa laga saaray suuq-geynta farmasiyada sababtoo ah.

"Acekledin": tilmaamaha isticmaalka

Prokinetics - maxay tahay, sidee iyo xaaladahee u codsanayaan? Xaalad waliba, la-talin dhakhtarku waa qasab iyo soo bandhigid taxadar leh tilmaamaha isticmaalka.

"Aceclydine" waxaa loo isticmaalaa si loo baabi'iyo luminta laf-dhabarka mareenka caloosha iyo mindhicirka ka dib qaliinka, waxay yareyneysaa cadaadiska indhaha, sidaas darteed waxaa loo isticmaali karaa dhakhtarka indhaha. Foomka siideynta - xalka loogu talagalay cirbadeynta, ayaa lagu duraa subageynin ilaa 1-2 ml oo xal ah 0.2%. Qiyaasta ugu badan ee hal qol soo dhaweyntu waa 0.004 g, maalin aan ka badnayn 0.012 g. Dhibaatooyinka kale waa feejignaan, dhidid, shuban.

Xanuunka khatarta ah ee loo isticmaalo waa cudur wadnaha ischemic ah, kor u kaca HDL, neefta neefta, hyperkinesia iyo parkinsonisms kale, uurka, dhiigbaxa ka yimaada caloosha.

"Fiziostigmin" ugu horayn waxa loo isticmaalaa in ku dhaqanka indhaha, laakiin mararka qaarkood u isticmaali kartaa in gastroenterology at paresis xiidmaha. Daawada waxaa lagu duraa maqaarka illaa 0.5-1 ml oo ah 0.1% xal. Xaddiga ugu badan ee daroogada maalintiiba waa in aan ka badnayn 0.001 g.

Dhibaatooyinka kale ee soo noqnoqda ayaa sii kordhaaya saliid, bronchospasm, isgoysyada muruqyada mindhicirka, isbeddellada garaaca wadnaha, qalal.

Contraindications: Xinjirowga angina, suuxdinta, neefta neefta, xakameynta mindhicirka farsamada, peritonitis, sepsis, uur.

"Galantamine": tilmaamaha isticmaalka

"Galantamine" ee xaaladaha gaarka ah waxaa loo isticmaalaa sidii antagonist loogu talagalay nasinta muruqyada ee xilliga postoperative iyada oo hoos u dhac ku yimaada muruqyada murqaha mindhicirka iyo kaadiheysta. Xanuunka khatarta ah ee loo isticmaalo waa xanuun badan, suuxdin, neefta neefta, cadaadiska dhiigga ee ka sarreeya 139/99 mm Hg, COPD, xakameynta farsamooyinka mindhicirka mindhicirka, hoos u dhaca shaqada kelyaha, da'da illaa 9 sano. Xaddidaadda ujeedada uurka ee xaaladahaas oo ah meesha dhibaatada iman karta ay ka badan tahay faa'iidada. Inta lagu jiro nuujinta waxaa loo gudbin karaa ilmaha iyada oo loo marayo caanaha.

Dhibaatooyinka kale: hoos u dhaca wadnaha, TTP, AV blockade, extrasstole, lallabo, matag, shuban, dyspepsia, muruqyada muruqyada, ceshad la'aanta, hematuria, tremor.

Waxaa loo maamuli karaa subcutanously, intramuscularly, xididdo, si joogto ah, hadal ahaan. Qaadashada waxaa loo xushay si gooni ah, oo ku salaysan anamnesis ee cudurka, waana in uu saxo dhakhtarka ka qaybgalaya. Celcelis ahaan, qaadashada maalin kasta ee dadka waaweyn waa 10 ilaa 40 mg oo loo qaybiyey laba ama afar qiyaasood.

Prokinetics ee jiilka cusub

Natiijada natiijada, daawooyinka sida "Ganaton", "Itomed", "Pramer" ayaa maanta la soo saaray. Mid ka mid ah kuwa cusub ee ugu wax ku oolka badan waa prokinetics ee jiil cusub, sida "Isuduwidda" iyo "Diyaarso". Inkastoo ay saameyn xun ku yeelan karaan shaqada wadnaha.

Kuwa ugu caansan ee ka shaqeeya gastroenterists ayaa weli "Motilium" (walaxda firfircoon - domperidone), oo isku daraya tayada metoclopramide, laakiin ma laha cawaaqib xun.

Maxay yihiin naadiyada ugu fiican? Liiska daroogooyinka ee maanta jira waxaa ka mid ah:

1. "Calaamadaha firfircoon" - "Ganaton", "Ismaandhaaf", "Primer" (magacyada ganacsiga).
2. "Metoclopramide" - "Reglan", "Cerucal".
3. "Cisapride" - "Isuduwid", "Prepulsid."
4. "Domperidon" - "Motilium", "Motilak", "Motinorm", "Passage".

Hadda waxaan ognahay nuxurka rasmiga ah. Liiska iyaga, sida aad arki karto, waa mid aad u ballaaran. Laakiin xusuusnow, ka hor intaadan isticmaalin wax daawo ah waxaad u baahan tahay inaad la tashato dhakhtar! Caafimaadkaagu ha ahaado!