The daroogada "valparin": tilmaamaha loo isticmaalo, halabuurka, micne ah, u dhigma. Reviews of diyaarinta

Maxaan ugu baahanahay inaan daawo "valparin"? Tilmaamaha loogu isticmaalo, micne ah oo muujinaya daroogada this waxaa lagu qeexay in this article.

The qaab iyo halabuurka ka mid ah

Waa maxay foomka waa asalka ah ee daroogada "valparin"? Tablet - waxaa foomkan daroogada ee su'aasha waxa laga iibsan karaa farmashiyaha. Waxay muujiyaan tallaabo dheer, qaab biconvex wareegsan, iyo daahan a color white.

qayb ka mid ah daroogada "valparin"? Guide bixisaa in qalab ku jira acid valproic iyo valproate sodium. Waxaa kaloo ka mid ah excipients soo socda: glycerol, Silicon Kolloidol dioxide, evdragit E-100, hydroxypropylmethylcellulose, tones polyetylen 1500, ethylcellulose, saccharin sodium, hydrate Silicon dioxide, evdragit MA-30D, titanium dioxide iyo Rusheyn kartaa.

kiniiniyada iibso waxaa laga daawan karaa in strips of 10 xabbadood xidhmada kartoonada ah siday u kala horreeyaan.

daawooyinka

Sidee daroogada "valparin"? Tilmaamaha loogu isticmaalo (Halabuurka waxay ka dhigan tahay ayaa kor lagu sharaxay) sheegayaa in ay tahay daroogada ah anticonvulsant. Waxaa ku jira content a valproate sodium of qaadidda reer Gebacna ee maskaxda, taas oo ku kordhinaya midhihiisa ee neurons postsynaptic.

Waa in la sidoo kale in component ee su'aasha saamaysaa gaadiidka ee udhigo potassium ee guud ahaan xuubka neuronal xusay. Hawlgalkani waxa lagu cabudhibayo horumarinta iyo faafinta ee excitation suuxdin in fiiloyin dareemayaasha.

Waa in sidoo kale lagu sheegay in valproate sodium saamayn anticonvulsant ee noocyada kala duwan ee kansarka beerka.

Drug "valparin" ma hanti ku dejinaysaa iyo saamaynta hypnotic, iyo ma diiqadoodo xarunta neefta. Intaa waxaa dheer, in ay qayb firfircoon laha waxyeello ka soo gaartey garaaca wadnaha, heerkulka jirka bukaanka, uu cadaadiska dhiigga iyo shaqada kelyaha.

The guryaha ogeed daroogada

Maxay yihiin astaamaha pharmacokinetic daroogada uu leeyahay "valparin"? Guide ayaa sheegay in ka dib markii qaadashada kaniiniga gudaha saamaxaad gacanta oo ah walaxda firfircoon isla markiiba bilaabmaa, iyo 2-8 saacadood ka dib, gaadho heer plasma ugu badnaan.

hab bioavailability tixgeliyaa 100%.

Saamaynta daweynta ee daroogada ayaa u muuqda oo kaliya ka dib markii lagu gaarey fiirsashada valproic acid in dhiig, loo siman yahay 45-100 mg / l. Waxaa la qadariyo, in falalkii daweynta iyo pharmacological of habka ay gacanta qayb muhiimka ah in la sii daayo ma had iyo jeer ku xiran tahay uruureen plasma ah.

Isgaarsiinta tixgeliyo daroogada borotiinka plasma waa qiyaastii 85-90%. Waxaa la metabolized beerka iyo waa wax soo saarka si wadajir ah ula kaadida. In this-pass ugu horeysay-shiid ayaa lagu arkay.

Half-nolosha ee wakiilka ku saabsan tahay 9-20 saacadood. In carruurta, muddo this waa la dhimay.

Tilmaamayaasha gelitaanka

Under xaaladaha waxa daroogada ugu fiican u dhaqmo "valparin"? Tilmaamaha loogu isticmaalo, dhabta ah warbixin khibrad iyo xirfad yidhi medicament waxaa si gaar ah soo saaray lagu daaweyn jiray suuxdin guud, oo ay ku jiraan noocyada soo socda weerarro:

• myoclonic;
• maqnaansho;
• atonic;
• tonic-clonic.

Sidoo kale, daroogada taas waxaa loo qoray, waayo, suuxdin qayb, iyo in ka badan si gaar ah, at:

• qalal guud sare;
• marka la isku daro ama qalal fudud.

Intaa waxaa dheer, kiniinno badan daawadaan isticmaalaa marka a syndromes gaar ah (Lennox-Gastaut syndrome, West).

Oo mamnuucday isticmaalka kiniiniyada

Waxay leedahay wax kasta oo sababo daroogada "valparin"? Sida laga soo xigtay tilmaamaha ka qalab, waxaa jira xayiraad badan isticmaalka:

• inta aad uurka leedahay,
• xanuunada daran ee beeryarada,
• Torombositobiiniya;
• hepatitis daran ama joogtada;
• porfyri;
• Xaaladaha hepatitis firfircoon (Bilowgii daroogada);
• naas-nuujinta,
• da'da carruurta ilaa saddex sannadood ah,
• diidmo in daroogada, oo ay ku jiraan in valproic acid.

Anticonvulsant "valparin": tilmaamaha loo isticmaalo

qiyaasta of daroogada la doortay si gaar ah, taas oo ku xidhan miisaanka jidhka iyo da'da bukaanka.

Sida caadiga ah, ee dadka waaweyn, dose hore ee daroogada of 600 mg maalintii. In ka socda tirada this kordhay 200 mg (saddex maalmood oo kasta si loo gaaro natiijada la rabay).

aqbaliddoodii badnaanta ka dhigan tahay hoos tixgelin waa 1-2 jeer maalintii. qiyaasta ugu badan ee lagu talinayaa waa 1-2 g of daroogada ah maalin kasta.

Kiniiniga "valparin", tilmaamaha loo isticmaalo kaas oo waxaa loo arkaa in warqad this in la wada liqo oo dhan, cabbi qadar yar oo ah biyo diiran.

In dadka waayeelka ah mudada kacmaha qalab this la mid tahay mudada kacmaha in bukaanada qaangaarka ah, laakiin loo doortay shakhsiga ku saleysan.

Waayo, carruurta oo miisaankeedu yahay 20 kg dose hore ee medicament waa 400mg maalintii. Waxaa lagama maarmaan ah in la kordhiyo xaddiga si tartiib tartiib ah si loo gaaro natiijada la rabay (oo ku saabsan 20-30 mg / kg maalintii, in 1-2 qaadasho).

Child oo miisaankeedu yahay ilaa 20 kg u yeelaan daawo anticonvulsant waa ka mamnuuc.

Waxqabadka by-qof

Waa maxay dhibaatooyinka soo raaca sababta "valparin" kiniin? Tilmaamaha loogu isticmaalo la socodsiinayaa in qaadashada daroogada this ee bukaanka aadanaha la kulmi karaan Waxyeellooyin:

• cadaanyo: Stevens-Johnson syndrome, finan maqaarka ah, multiforme erythema, pruritus, maqaarka, photosensitivity.
• nidaamka dheefshiidka: lallabo, hepatitis, matag, calool, shuban, pankreatit.
• nidaamka Taranka: sare, caadada joogto ahayn amenorrhea.
• Habdhiska: kooma, gariir, ataxia, miyir oo yaraada.
• nidaamka hemopoietic: dhiig la'aan, Iscelin xulkii dhiig xinjirowga, Torombositobiiniya, leukopenia, neutropenia, hoos u fibrinogen.
• Kale: miisaanka oo kordha, timaha, kariyaatiniin serum, hyperammonemia.

anticonvulsant badinta

Waa maxay astaamaha uu dhici karaa marka la qaato dhoos sare oo daroogada ah "valparin"? Tilmaamaha loogu isticmaalo (kiniiniga laga iibsan karaa farmashiyaha kasta on qoro) doodaysaa in taariikhda ah qiyaasta xad dhaafka ula kac ah ama shil ah ee daroogada ka yar tixgelin waxaa dhif sheegay. Sida caadiga ah, xad gudub ku ah kacmaha ee daroogada ku kordhinaya muuqashada lallabo, wareer, matag, shuban, niyad-jabka neefsashada, kooma, iyo hyporeflexia.

Si aad u baabi'iyo xaaladaha sida bukaanka loo qoray lavage gastric iyo dhuxusha firfircoonaan. Haddii loo baahdo, daaweynta bukaanka waxaa lagu fuliyaa qaab therapy astaamaha iyo kelyaha.

Dhexgalka daroogooyinka kale

Haddii galay is dhexgalka daroogooyinka kale daawada "valparin"? Tilmaamaha loogu isticmaalo wargelinaysaa bukaanka in valproate sodium si xoojin saamaynta jirada dhimirka, murugada iyo daroogada antiepileptic.

Si ka duwan kale anticonvulsants , ma daroogada loo arkaa kor u induction enzyme cagaarshowga, oo sidaas daraaddeed ma yareeyo waxtarka piller.

In soo dhaweynta isku midka ah "warfarin" iyo valproate sodium hoos boqolleyda qabanaya borotiinka plasma ugu horeysay.

The walax daroogada firfircoon waxaa loo arkaa inay awoodaan in la beddelo uruureen plasma of lamotrigin, iyo phenytoin. Marka la isku daro la taagayo daawada xinjirowga lidka acetylsalicylic acid iyo saamaynta antiplatelet waa wanaajiyey.

Iyada oo la isticmaalo isku mar "valparin" ka ethanol iyo daawooyinka kale ee ku tuuji habdhiska xiran (tus, MAO waa murugada tricyclic, daawooyinka ee waallida dajiya) waxaa laga yaabaa in kor loo niyad-jabka habdhiska dhimirka.

Khamriga iyo daroogada kale hepatotoxic kordhiyaan halista waxyeellada beerka.

dejinta viewed kordhiyaa badhkiis nolosha "lamotrigin" iyo caanuhu ay shiid iyo cabudhibayo ensaymes cagaarshowga. In xidhiidh la leh this nus-nolosha ee daroogada kor lagu kordhin karaa ilaa 70 saacadood in bukaanada qaangaarka ah iyo ilaa 45 saacadood - carruurta.

"Valparin" waa inay awoodaan inay yareeyaan ansixin "zidovudin" by saabsan 40%. Waxaa intaa dheer, in ay bar-nolosha aysan waxba ka beddelin.

MAO Inhibitors murugada, tricyclic iyo daawooyinka ee waallida dajiya (neuroleptics), iyo sidoo kale daawooyinka kale ee hoose marinka qabashada, la taaban karo u yareeyaan waxtarka medicament u tixgeliyo.

Naas-nuujinta iyo uurka

Sida laga soo xigtay khubaro, isticmaalka "valparin" daroogada inta lagu guda jiro uurka waa keliya haddii faa'iidooyinka loogu talagalay in hooyooyinka mustaqbalka si weyn u badan tahay halista ka iman karta ilmaha.

Marka la helo daawada inta ay uurka leedahay, hubi loo sameeyo korjoogteynta gaar ah dhalmada ee ilmaha caloosha ku.

Isticmaalka daroogada lagu jiro nuujinta laguma talinayo.

macluumaad gaar ah

Inta aanad bilaabin daaweynta lacag ah, hubi inaad la tashato dhakhtarkaaga.

In geeddi-socodka ah ee qaata daawooyinka anticonvulsant u baahan tahay la socodka joogtada ah ee bilirubin ee dhiigga, amylases iyo platelets, iyo sidoo kale transaminases beerka (3 biloodba mar).

Sida laga soo xigtay khubaro, valproic acid waa awood u anada xulkii dhiig xinjirowga. Tani waxay si weyn u kordhiyaa khatarta ah kor u kacay waqti xinjirowga dhiigga dhiig. Waxaa lagama maarmaan ah inay tixgeliyaan suurtagalnimada of dhibaatooyin kuwaas oo la xiriira dhiig muddada postoperative, in dadka qaata valproate sodium.

Haddii daaweyn muddada-dheer ee daroogada this in bukaanka laga yaabaa in dhiig isxilqaamay iyo hematoma sameeyay. Xaaladdan oo kale, kaniiniyada waa in isla markiiba la joojin.

Sida kor ku xusan, valproate sodium, daroogada oo inta badan sababa ganaca, iyo sidoo kale kor u carqalad ah beerka (sida caadiga ah in 6 bilood ee ugu horreeya ee daaweynta). Marka tan la eego, bilowga ah ee daaweynta loo baahan yahay si ay ula socdaan xaaladda bukaanka kansarka ganaca, iyo sidoo kale in si joogto ah loola socdo baaritaano beerka, iyo heerka prothrombin.

Xanuunka of beerka iyo failure cagaarshowga in bukaanlayda qaadato valproate sodium oo laga dheehan karo in carruurta la qalalka ee cudurada dheefshiidka iyo side, dhimaal maskaxeed iyo organic cudurada unugyada maskaxda.

In daawashada ka mid ah Calaamooyinkiisa sida feejignaan xumo, tabar calaamadeeyay, barar, iyo matag, joonis, waa in si degdeg ah u joojiso isticmaalka medicament ah.

In daaweynta "valparin" bukaanka waa in ay ahaataa mid aad u taxaddar marka la mashiinno khatar ah ka shaqeeya. Tan waxa u sabab xaqiiqada ah in medicament firfircoon yahay oo awood u leh yaraynta-fiirsashada.

Shuruudaha iyo xaaladaha kaydinta

kaniiniyada Anticonvulsant "valparin" siiyey farmasiyada oo kaliya on warqad dhakhtar ee. Waa in ay lagu kaydiyaa meel carruurtu aanay gaarin iyo in laga ilaaliyo qoyaanka iyo heerkulka a aan ka badnayn 30 digrii.

Nolosha shelf ee daroogada ka yar tixgelin waa saddex sano (oo ka bilaabmaysa maalinta la sameeyay).

Medicament "valparin": analogues, micne ah

daroogada ee su'aasha waxaa lagu beddeli karaa? Micne ah iyo analogues in qalab this, waxaa jira dad badan. Kuwaas waxaa ka mid ah daawooyinka hoos ku qoran: "Apilepsin" "Depakine," "Atsediprol" "Depakine Enterik" "Depakine Chronosphere" "Depakine Chrono", "Dipromal", "Konvulsofin", "Konvuleks", "Orphir" "Enkorat", "Everiden", "Enkorat Chrono".

Sida kiiska la "valparin", lacagtaas waa in la sameeyaa oo keliya dhakhtarka amar, in qaadashada talinayaa adag.

opinion ee macaamiisha iyo xirfadlayaasha

Maxaa dhakhaatiirta yidhaahdo oo ku saabsan dawadan, sida "valparin"? khubaro Guest ayaa tilmaamaya in daroogada waa mid aad u wax ku ool ah oo hufan, gaar ahaan suuxdin guud oo qayb ahaan.

Sida macaamiisha, intooda badan oo ka mid ah raacsan tahay fikrad ah ee dhakhtarka. Bukaan-socodka ku doodaya in aqbaliddoodii taasi ka dhigan tahay fududeeyaa horumarka degdeg ah iyo faafin xakamaynayaan excitation (suuxdin) by neurons. Si kastaba ha ahaatee, waxaa la ogaadaa in isticmaalka daawada waxa ay inta badan sababa waxyeelo. Sida laga soo xigtay war celin macaamiisha, ee inta badan ka dhaca dhibaato kala yihiin: Xasaasiyadda maqaarka, lalabo, dhiig, iyo miisaanka oo kordha. Haddii aad isku aragto calaamadahan waa in isla markiiba la xiriir dhakhtar.