Anti-TPO - baaritaan xasaasi ah lagu ogaado Graves, shalalka

Oo ay la socdaan cudurada nidaamka wadnaha socdo xanuunada koritaanka iyo hormoonada jidhka - macaanka iyo thyroid lesions noocyo kala duwan ah.

Ka mid ah dambe ee degan hypothyroidism ah meel gaar ah, tan iyo markii ay muuqaalka ee carruurnimada sababa la'aan ba'an oo horumarka maskaxda iyo jirka ilmaha. Inta badan, waxa loogu yeero Graves, shalalka ama Hashimoto ee. In cudurkan ku dhici kara saddexda nooc kiliinikada. hypertrophic Tani, taas oo ah magdhawga kelyaha qanjirka thyroid ka, Atrophic, horumarinta marxaladda labaad ee cudurka oo waxa lagu gartaa badalka qaab dhismeedka unugyo caadi ah, iyo alopecia at kaas oo nabar daboolayaa kaliya hal jirka share.

falanqaynta muhiimadda

Inta badan, caddaynta kaliya ee saxda ah ee uu cudurku waa la ogaado dhiigga anti-TPO, i.e. unugyada perodoxida thyroid - enzyme hoose triiodothyronine formation iyo tyroksiini.

Sababta oo ah hawl waxaa carqaladeeyey iodination of thyroglobulin, protein dhismaha thyroid in blocks marxaladaha Avv dheeraad ah hormoonada ay. Tan iyo markii ay tani waa imtixaan ugu xasaasiga ah ee cudurka of goiter Hashimoto ee, ka dibna dhakhtarka tuhunsan yahay inuu cudurka loo xilsaaray baaritaanka dhiigga hormoon. Anti-TPO in ay dhacdo natiijo fiican la kordhin doonaa, oo markaas cudurka waxaa gebi ahaanba ku tijaabiyey. Kaliya kiiskan, dhakhtarka xaq u yeelan doontaa in ay ku taliyaan daaweynta ku haboon iyo in la siiyo saadaal wanaagsan ee bukaan socodka. Gaar ahaan muhiim u tahay baaritaanka loogu talagalay haweenka uurka leh, t. Si aad., Haddii ay kor u muujiyaan anti-TPO, waxaa ku hadla ee ku saabsan halista khatarta ah ee soo koraya Graves dhalmada iyo saamaynta kalliftey of cudurka on uurjiifka. Heerka antibodies, kuwaas oo sida caadiga ah waa 0-5,6 IU per mililitir ee serum, iyo hoos u dhac laga dheehan karo in dad caafimaad qaba oo ka yar da'da 50 sano. Laakiin positive (anti-TPO kor caadiga ah) Baaritaankaan waxaa laga yaabaa in cudurrada kale ee qanjirka thyroid, sidaas cudurka of heley waa in la sameeyo khasab adag, wada jir ah ula falanqayn on T3, T4 iyo TSH.

cilmi-adag

cudurka Hashimoto ee waxay dhacdaa marka failure ah habka difaaca jirka, kuwaas oo, marka ay tahay wax ka qabashada xad-dhaaf ah ama yareynta dhaqdhaqaaqa T-suppressor ah. Sidaa darteed (oo ay la socdaan anti-TPO) dhiigga bukaanka waxaa laga helaa unugyada kale: Qaabkadhismeedka sida thyroid (jajab microsomal thyroglobulin) iyo xubnaha kale gebi ahaanba. Taas ayaa ka dhigaysa ku daraan kale, ma hormoonada jidhka, heley ka soo jeedo, shalalka. Waxa intaa dheer in imtixaanka anti-TPO iyo hormoonnada, lagama maarmaan goiter xaqiijin qalab Hashimoto. Sidaas darteed, inta lagu guda jiro baaritaan ultrasound ah qanjirka thyroid ah muujin kartaa heterogeneity ay qaab-dhismeedka, hypoechogenicity qaybaha qaar ka mid ah, joogitaanka kalshum iyo dhagid kaabsolka. saadaal More daran noqdo xaaladaha uu xubin ka noqon doonaa qanjidhada sida qiyaastii 5% ee kiisaska ay ozlokachestvlyayutsya.