Inhibitors anhydrase Carbonic: qaab hawleed ee indhaha lagu dhibciyo gulukooma

inhibitors anhydrase Carbonic waa diuretics, kuwaas oo aan la isticmaalin sida diuretics ama mochegonki. Tilmaan daroogo waa gulukooma. Ha ka fikiro si aynu si faahfaahsan kuwa ugu caansan.

Acetazolamide (Acetazolamide)

Waxa uu ku durayo. Istaago anhydrase carbonic tubules proximal kelyaha yaraynaysaa nuugay ee K, Na iyo biyaha (diuresis sababa kordhay), waxa ay keenaysaa in hoos u dhac in ku BCC iyo aysiidh dheefshiidka. anhydrase Carbonic depresses jirka ciliary ah iyo keenaysaa in a cayimay cadaadiska intraocular, iyo sidoo kale hoos u dhigtaa dheecaanka ee kaftan aqueous maskaxda ku keentaa waxqabadka antiepileptic. Waxay leedahay nuugista wanaagsan ka mareenka caloosha iyo mindhicirka ee, Cmax ee dhiigga ee laba saacadood. Saamaynta socon kartaa ilaa 12 saacadood. 40-60% hoos u Rettigheter iyo yaraynaysaa wax soo saarka ee dareeraha intraocular.

Tilmaamayaasha & Qiyaasta

Ififaalaha waaweyn: hypertension indhaha ah, gulukooma. In glaucoma, gudaha qaadan on 0.125-0.25 g 1-3 jeer maalintii, maalin walba muddo 5 maalmood ah, ka dib markii taas oo u baahan nasasho laba maalmood ah.

Dhibaatooyinka ay keento: lallabo, rabitaanka cuntada oo luma, shuban, xasaasiyad, dareen oo yaraada ee taabto, paraesthesia, tinnitus, dawakhsanaan. All this keeni kara inhibitors anhydrase carbonic. Diyaargaraw ayaa sidoo kale sababo. dareen Tani xad-dhaafka ah (in sulfonamides oo ay ku jirto), cudurka Addison ee, qabatinka si aysiidh, cudurka beerka ba'an iyo cudurka kelyaha, uurka, mellitus diabetes, uremia.

xayiraad Isticmaalka: lungemboli, emphysema pulmonary (suurto gal kordhaya aysiidh).

The daroogada: Kiniinka soo saaray Poland Polpharma "Diakarb" in ay 0.5 g

Dorzolamide (dorzolamide)

Gudhiyay anhydrase carbonic isoenzyme II Activity (Bilaabay reaction fuuq karo ee carbon dioxide iyo carbonic acid dehydration) jirka ciliary isha. Dheecaan qoyaan intraocular waa la dhimay by 50%, caanuhu formation of udhigo bicarbonate, oo qayb ahaan ay yaraynaysaa gaadiidka biyaha iyo sodium. Dhimay 38% wax soo saarka ah ee dareeraha intraocular in wax saameyn ah kuma dheecaanka. Waxaa guskiisa galay bu'da badan iyada oo loo marayo addinka, wilka ama sclera. Qayb nuugo galay sariirta systemic vascular ee xuubka Eye ah (yaabo inay ka dhacaan durayo iyo saamaynta kale sulfonamides caadiga ah). Ka dib markii maalkii ayaa dhiiga, si degdeg ah guskiisa galay unugyada dhiigga cas, oo ku jira xaddi badan oo anhydrase carbonic II. Dorzolamide 33% xidhxidhan u borotiinada plasma. The saamayn hypotensive badnaan teedu ka dib ku keento ka dhex 2 saac ah oo u dukaamada 12 saacadood. Marka backfilling ilaa 2 jeer at 9-21% maalin kasta hoos u cadaadiska intraocular markii Ruhbaaniyad sida 3 jeer maalintii - in 14-24%. Dhimista cadaadis intraocular adigoo isticmaalaya xal 2% ka dhigi kartaa ugu badnaan 4,5-6,1 mm Hg. Xalka of 3% noqon lahaa wax ku ool ah ka yar, sababtoo ah waxaa si deg deg ah ku maydheen doonaa of saabka conjunctival sida uu keeno inuu dillaaco xoog leh. In lala timolol ballanta leedahay saamayn fahmayaan dheeraad ah ka 13 ilaa 21%. saamaynta ugu yar ee cadaadiska dhiigga iyo garaaca wadnaha leeyihiin inhibitors anhydrase carbonic. Diuretics kooxdan aan la isticmaalo ay ujeedada loogu tala galay. On this ka dib.

Tilmaamayaasha & Qiyaasta

Tilmaamayaasha: hoose iyo sare glaucoma furan-xagal, hypertension indhaha ah. Daawada waxaa ka muuqata 1 dhibic 2-3 jeer maalintii.

Dhibaatooyinka ay keento: paresthesia, miisaanka oo yaraada, murugada, finan maqaarka, aplasticheskayaanemiya, Agranulocytosis, daal, madax xanuun, necrolysis epidermal sun ah, dhadhan qadhaadh oo afka, lalabo, korodhka dhumucda wilka, iridocyclitis, blepharitis, keratitis, conjunctivitis, photophobia, aragti cawlan, cuncun iyo jidhidhico dareen indhaha, raaxo, Stevens - Johnson syndrome, gubasho, indhaha-biyood.

The inhibitor anhydrase carbonic (dhibco lagu shubo indhaha) ayaa sababo socda: dareen xad-dhaaf ah (oo ay ku jiraan in sulfonamides), carruurnimada, cudurka beerka ba'an iyo cudurka kelyaha, uurka iyo nuujinta.

Diyaarinta: gulucdooda "Trusopt" oo ka kooban 1 ml of 20 mg xal hydrochloride dorzolamide. fijaan - 5 ml. Waxaa la soo saaray dalka Holland by Merck Sharp & Dohme.

inhibitors anhydrase Carbonic: Brinzolamide (brinzolamide)

xanibaha cusub oo anhydrase carbonic isagoo awood u leh marka laga dhayayo codsatay in ay hoos u muhiim ah oo Rettigheter gacanta. Brinzolamide leeyahay selectivity sare ee anhydrase carbonic II, iyo guryaha jirka ugu haboon si wax ku ool dhex gelin galay isha. Marka la barbar dhigo dorzolamide iyo atsetozolamidom helnay brinzolamide in - kooxda walax ugu qatarsan ee inhibitors anhydrase carbonic. Waxaa jira cadaymo muujinaya in maamulka la mariyo ama xididka of brinzolamide keenta in horumar ee disk ee optic. Oo waxay hoos u dhigtaa celcelis ahaan ah 20% Rettigheter. Waxaa uma shaqeeyo oo dhan inhibitors anhydrase carbonic. hab ay of tallaabo gaar ah ka brinzolamide.

Tilmaamayaasha iyo qiyaasta

Tilmaamayaasha: hypertension indhaha ah, glaucoma-xagal furan. Isticmaal 2 jeer maalintii for dhibic.

Dhibaatooyinka ay keento: qasnaan dhadhanka, dareenka jirka shisheeye, aragga indhaha oo isku darsamay dul keento (waqti) iyo dareen gubasho ah. Wareejiyo degaanka ka khayr badan dorzolamide.

Sababo: dareen xad-dhaaf ah si ay daroogada (in sulfonamides oo ay ku jirto), da'da, uurka carruurta iyo naas-nuujinta.

Diyaarinta: gulucdooda "Azopt" oo ka kooban 1 ml of ganaax ah 10 mg brinzolamide. fijaan Capacity of 5 ml. Soo saaray ee USA by Alcon.

Maxaa kale waa inhibitors anhydrase carbonic?

taagayo prostaglandin

Latanoprost (latanoprost) - receptor prostaglandin agonist la xushay. Kordhay dheecaanka of dheecaan intraocular dhex uvea ah, taas oo horseedaysa a hoos cadaadis intraocular. Saameynta wax soo saarka ee kaftan aqueous ma kaa caawin doona. ka beddeli karaa baaxadda ardayga, laakiin wax yar oo kaliya. Marka backfilling irbadu qaab ether isopropyl dhex wilka iyo waxaa hydrolyzed gobolka of acid ah bayoloji firfircoon, taas oo lagu qeexi karaa in 4 saacadood ee ugu horeeya ee dareeraha intraocular iyo plasma ee saacaddii ugu horeysay. 0,16l / kg - mugga of qaybinta. Laba saacadood ka dib waxaa dheer gaari tirada ugu badan ee kaftan ah aqueous, ka dib markii taas waxaa loo qaybiyey bilowgii qeybta hore, i.e. xirribaha iyo conjunctiva ah, ka dibna galo qeybta dambe ee (xaddi yar). foomka firfircoon ee unugyada isha waxaa ficil ahaan ma metabolized, inta badan ee biotransformation beerka. Advantageously, metabolites waxaa raaca kaadida. Bal aynu eegno qaar ka mid ah inhibitors anhydrase carbonic.

Unoprostone (unoprostone)

unoprostone Isopropyl waa derivative ah docosanoid ah si degdeg ah la yareeyo cadaadiska intraocular (Rettigheter) oo isticmaalaya farsamo ugu dambeeyay pharmacologic. Haddii aan la beddelo wax soo saarka waqtiga dheecaanka intraocular ah, fududeeyaa ay soo qaxeen. Daraasado ayaa muujiyey in, iyadoo 0.5% marka la barbar dhigo maleate timolol, unoprostone isopropyl ayaa hawl la mid ah ama ka sii fiican in la yareeyo Rettigheter. Daawada uusan saamayn ku lahayn hoy iyo ma keeno hoos u socodka dhiigga ee indhaha ah unugyada, miosis ama mydriasis; dib u dhac cusboonaysiinta corneal sidoo kale lama dareemo. Ka dib markii la mariyo unoprostone isotropy beddelin lama ogaan karo in plasma.

inhibitors anhydrase carbonic gulukooma waa in lagu qoro oo kaliya dhakhtar, is-daawo lama oggola.