"Montelukast": dib u eegista, tilmaamaha iyo analogues daroogada

"Montelukast" - oo ku saabsan dib u eegista daroogada si fudud waxaa laga heli karaa on forums online iyo goobaha u hurtaa sidii ay dhibaatada xiiqda - antagonist a classic of leukotriene 4 barbarro-receptor. Daawada waxaa si weyn loo isticmaalaa sida saldhig inta lagu jiro daaweynta iyo si looga hortago weerarrada caan cudurka. Halabuurka Balanced ogolaanaya isticmaalka daroogada ah si loogu daweeyo bukaannada ah ee ku dhawaad koox da 'kasta.

Form sii daayo

Sababaha "montelukast" inta badan heshay dib u eegista wanaagsan, wax badan. Si kastaba ha ahaatee, waxa ugu horeeya ee ah in dhaco ishaada - taasi waa, dabcan, noocyo kala duwan ah kiniin, iibin magaca ganacsiga ee xogta ku.

Waqtigan xaadirka ah geeddi-socodka waxaa ku badan saddex furta. Waxaa ku saabsan kiniiniga caadiga ah ay la socoto baqshad bireed a (1 unit ka kooban 10 mg oo ah walaxda firfircoon) iyo analogues ay qaadka (4 mg iyo 5 mg siday u kala horreeyaan of reagent) waa. salaysan Base labada kiis ee, u dhaqmo sodium montelukast, laakiin ka kooban dhowr qaybood oo kaabayaal ah oo kala duwan - Mannitol iyo aspartame joogaan in shaybaarka loogu talagalay qofku cuno degdeg ah inta lagu jiro isticmaalka.

In comments arrin inta badan waxa ay kor u booda su'aasha ah ee been abuurka ah, kuwaas oo hadda ka dibna u muuqdaan in silsilado farmashiyaha. Difaaco been-abuurka waxay noqon kartaa, haddii aan waqtiga mushaarka fiiro gaar ah u muuqaalka kore ee sheyga pharmacological.

Gaar ahaan, xanjo pill la 4 milligram ee firfircoon, waxa uu leeyahay qaab ah gadood iyo galyadeena pink (description u dhiganta kiniin la dhadhan cherry, iyadoo la isticmaalayo wax dhadhan kale kala duwan la ogolaan karo), iyo lambarada "4" hal dhinac calaamadeeyay. Analogs, taas oo qayb weyn ee firfircoon yahay 1 mg badan - wareegsanaa oo ku tilmaamay "shan". Kiniinka sidii qolof a geometrically eg leydi; Waxay beige iyo tiriyey "10" tirada.

tirsanaan koox pharmacological

"Montelukast" (tixraac ku tilmaamay xaalado ay reagent adag xanaajiyeen xasaasiyad waa naadir) - taasi waa wakiil caadiga ah ee daroogada kooxda antibronhokonstriktornyh. geynta wuxuu kuu ogol yahay falalkiisa ka hadlo a "Xiriirka dhow" la intermedianty / prostaglandins iyo thromboxanes.

Shaqada ugu muhiimsan ee daroogada - xanibeen cysteinyl leukotriene "dareemayaal" ee qaabka neefsashada. receptors Kuwani ilaaliyaan waxqabadka sare ee horumarinta neefta bronki iyo sidoo kale waxay kicin ereygu wuxuu ahaa ee dheecaanka oo markaas ururayaa iyo murug xabka.

qaadashada joogtada ah u keenaysaa in hoos u dhac weyn ee darnaanta calaamadaha ee asalka ah hoos u dhac guud ee tirada weerarada Xiiqda (sida uu u sheegay dad badan oo buka, isbedel wanaagsan oo ay horeba u arkay in maalmood ee ugu horreeya therapy).

Tilmaamo dheefshiidka

"Montelukast" (farmasiiyada dib u eegista soo jeedinaynaa in doorashada dhabta ah ee taagan-tago waa xadidan oo ay ku siyaasadda qiimaha farsameeya, ie qofka daroogada-micne ah, ku tilmaamayaa in ay ka kooban taagoo isku qaab-dhismeed waa qayb weyn ee, waxaa jira dhowr jeer ka qaalisan diyaarinta tilmaamay), gelaysa plasma ah dhiig, si fiican ayayna la borotiinada ay. Baaritaano, natiijada waxaa laga soo qoray at 99, 37%. Isla mar ahaantaana, ay bioavailability waa in saamiga si toos ah geeddi-socodka lagu soo saarista. Tusaale ahaan, waxyaabaha looxyadii 5-milligram kasteba si nuugista by 73%, halka analogues la dalaka xuub taas oo ay jirto 2 jeer Walxaha firfircooni dheeraad ah, - oo kaliya 64%.

Xaaladda A la mid ah la bar-nolosha ee reagent ah: Qaybaha cunista kiniinka, by lagu shiid, jidhka tagay 2 saacadood ka dib soo dhaweynta ka dib, laakiin waxyaalaha dastuurka kaniiniyada caadiga ah - 180-200 daqiiqo ka dib. In ansixin plasma this kala duwan 43-45 ml / daqiiqo. Iyo, si xiisa leh,% ee qiyaasta kaliya 0.2 waa gaadhsiiyey channels kaadida. Xiidmaha, by la barbardhigo, - in ka badan 85%.

From the comments maamulka ixtiraamo, waxaa soo socota in geeddi-socodka pharmacokinetic waa siman habsami leh ee bukaanka ah ee labada jinsiba, iyo in loo sameeyo qaar ka mid ah hagaajin halis ah da'da iyo cudurada kelyaha xisaabinta oo ka mid ah la cuno maalin kasta daawada loo baahan yahay. Laakiin fashilka beerka, gaar ahaan marka ay timaado cudur aad u daran, uu u qalmo in fiiro gaar ah diyaarinta jadwal-ku-daweyn.

Tilmaamayaasha waayo,

Marka xaq isticmaalka "montelukast" dib u eegista daroogada (caruurta dawada lagula talinayaa in qaab xanjo, kaniiniyada, dahaarka leh qolof xuub, waxaa lagu talinayaa in uu magacaabo oo keliya dadka waaweyn iyo dhalinyarada), ka tagay on forums, dabcan, ay nooga caawiyaan si ay u fahmaan. Si kastaba ha ahaatee, wuxuu uun u Hanuunay by opinion dadka kale - waa qalad weyn, sababtoo ah iyada oo aan la tashanaya dhakhtar, "si ay u aqoonsadaan ah" nooca cudurka neefta, iyo ugu muhiimsan - si aad u ogaato sababaha ay dhacdo waa ku dhowaad aan macquul ahayn.

Iyadoo la tixgelinayo war rasmi ah, goobada waxaa calaamadaha, nno iyo xaaladaha kale ee ku qeexan sida soo socota:

• dubaaxin bronki huriyay load jirka xad-dhaaf ah;
• / Rhinitt chronic xilliyeed, dabeecadda xasaasiyad ka soo jeedo,
• neefta,
• baahida loo qabo in tallaabooyin ka hortag ah.

qiyaasta si mug leh

"Montelukast" (feedback negative waa mid aad u adag tahay in la helo, maxaa yeelay qayb firfircoon ayaa muddo dheer si guul leh loo isticmaalo sida qayb muhiim ah oo badan oo daroogada) waxaa maamula hadal, hal mar maalintii, iyada oo aan samaynayn in jadwal "quraacda - qadada -. Casho"

Waayo, kiniin la calaashado, 4 mg iyo 5 mg jira xeerar qaadashada sida:

• carruur ay da'doodu u dhexayso 2 ilaa 5 sano: 1 unit of sheyga (4 mg) maalintii, waqtiga hurdada, ilaa la gaaro control of calaamadaha iyo dheereyn koorsada khasab ah 2-4 todobaad si uu u xaliyo saamaynta sababtay;
• bukaanka 6 ilaa 14 sano jir ah, hab la mid ah, laakiin heerka hal mar ah - 5 mg.

Waayo, kiniinka la duuban bireed ah oo la xiriira soo socda talooyin:

• dadka waaweyn iyo carruurta ka weyn 15 sano jir, ka cabanaya neefta bronki ama rhinitt chronic: 1 Unit (10 mg ah waxyaabaha) / maalintii fiidkii;
• si looga hortago in casiraad: dose isla waqtiga dherer bareeg ah 14-28 maalmood.

dhibaato

"Montelukast" edbinta (dib u eegista soo jeedinaya in xitaa si buuxda u waafaqsan hoggaanka rasmiga ah ee reactions atypical in joogitaanka maaddooyinka ilaa ugu dambaysta ma laga saari karo) waxaa la taagan yahay sida daroogada kara ammaan ah, laakiin la proviso in "wax ka qabashada" on qayb ka mid ah jirka oo in kiisas shaqsi ah non-gaar ah weli suurtagal ah.

seenyo ogol yahay:

• GI: shuban, afka oo qalala, xanuun syndrome caloosha, yaqyaqsi,
• Khadadka wadnaha iyo dhiig, koror aad u muhiim ah in heerka garaaca wadnaha,
• finan maqaarka ah, urtikaria, hematoma degaanka;
• neefsashada, sanka oo dareera iyo qufac,
• Habdhiska: wareer, daal, niyadda murugada talantaalli ah u cadhoodaan psychomotor xad-dhaaf ah;
• muruqyada: myalgia iyo arthralgia (oo ay ku jiraan qalal.).
• Kale: calaamadaha caan ku caabuqyada neef ba'an iyo hargabka.

Xudduudka iyo sababo

"Montelukast" (tilmaamaha loogu isticmaalo waa dib u eegista ugu wanaagsan, iyo macluumaadka ku jira waxa ku jira, marka la eego dhexdhexaadnimada, su'aalo xubno ka mid ah golaha durba waa ma jiro) looma adeegsan doono haddii:

• Waxaa laga helay dareen dheeraad ah sidiisa daawooyinka (guud ahaan run, waayo, dhammaan noocyada kala duwan ee kiniin);
• ogaadaa cudurka dhif dhaxlay, oo ay ku jiraan kuwa ku jira kaas oo u shaqeeyo ma milmi galactose ama la kulma deficiency lactase muhiim ah (xadaynta this ma khuseeyo cunista kiniinka);
• bukaanka waa dhibteen phenylketonuria,
• bukaanka ayaa weli ma soo jeestay laba sano, (waayo, kiniinada "da'da xaddidan" - 15 sano).

Iska badinta: Calaamadaha iyo Daaweynta

Daraasado ayaa muujiyey, "montelukast" 4 mg (tixraacyo ku saabsan qaab ganacsi this of reagent ah, dhab ahaantii, isku si comments in looga qaadka analogs ka kooban 5 mg oo ah walaxda firfircoon) in ka badan heerka isticmaalka maalin ayaa saameyn la mid ah sida 10 kiniin mg . Calaamadaha ugu dhawaaqaa ah qiyaasta xad dhaafka loo arki karaa in bukaanka koox yar. Dadka waaweyn, xitaa marka la qaadanayo 200 mg / maalintiiba 5 bilood, qaar ka mid ah falcelin aan caadi ahayn ayaa la arkay.

The hal dhacdooyin calaamad of isugu uruuray kordhay ee daroogada waa:

• harraad aan demeyn;
• dawakhsanaan;
• Calool xanuun aagga;
• matag,

Daaweynta waxaa lagu fuliyaa, ku saleysan sawirka caafimaad oo lagu arkay. Warbixin ku saabsan waxtarka of maqan kelyaha.

isdhexgalka Drug, iyo analogues ugu caansan

"Montelukast" 5 mg (dib-qaadka baarka ka tagay by takhaatiirta carruurta, hoos u karkariyo in fikradda ah in daroogada, shaki kuma jiro, mid istaahila in dareenka waalidiinta dhallinyarada), iyo sidoo kale noocyo kale oo antagonist receptor leukotriene, marka loo isticmaalo in barbar wakiilada ku habboon si loo dardar-ka dhaqdhaqaaqa wanaagsan : calaamadaha neefta noqdo yar daran, tirada weerarada hoos. Si kastaba ha ahaatee, ka bixitaankii kadis ah therapy qaadeen ku saleysan corticosteroids neefsado laguma talinayo.

kala duwanaansho weyn ee geedi socodka pharmacokinetic ku lug theophylline iyo prednizola ogaado. Laakiin nuugista ee "urur" la phenobarbital hoos by sida ugu badan ee 40%.

Reagents in la xakameeyo ereygu wuxuu ahaa ee isoenzyme CYP3A4, waa in la isticmaalaa oo kaliya ka yar kormeer caafimaad.

analogs Dhismayaasha in inta badan lagu on sale:

• "Monkasta".
• "Singlon".
• "Singulair".
• "Ektalust".
• "Singuleks".

"Singulair" ama "montelukast": dib u eegista ah dhakhaatiirta iyo farmashiistayaasha

Sida laga soo xigtay pharmacologists khabiir, ka doodista oo ku saabsan taas oo ka mid ah daroogada waa ammaan iyo in ka badan wax ku ool ah, wax aan waxba tarayn, tan "Singulair" iyo "montelukast" waa mid ka mid ah oo saldhig ka mid ah dawooyinka. Just maray magaca diiwaangelinta ugu horeysay patent, iyo tan labaad waa heerka caalami. dhakhtarro Individual iyo bukaanka, si kastaba ha ahaatee, waxay qaadataa aragtiyo kala duwan oo ka fiirso daawo loo qaybiyey ka hooseeya INN, go'aanka keliya ee saxda ah.