Qarni ugu dambeeyay ee NSAIDs: dib u eegista, qiimaha liiska

Dad badan oo isbedel ah cudur ku dhaca jidhka, Ulasocto xanuun. Si loola calaamadaha sida horumariyo NSAIDs ama anti-bararka non-steroidal wakiilka. Waxay si fiican u la kabuubyeyn, loo yareeyo bararka, yareeyo bararka. Si kastaba ha ahaatee, daawooyin badan oo waxyeelo badan. Tani xaddidaya suurtagalnimada ee ay u isticmaalaan dadka bukaanka ah qaar ka mid ah. Farmashiiste Modern ayaa sameeyay jiilka ugu dambeeyay ee NSAIDs. daawooyinka noocan oo kale ah aad bay uga yar tahay inay keenaan falcelin xun, laakiin waxay ku jirtaa daawooyinka wax ku ool ka dhanka ah xanuun.

saamaynta mabda'a

Waa maxay waxa u sabab ah saamaynta NSAIDs on jidhka? Waxay u dhaqmaan on cyclooxygenase ah. Cox waxay leedahay laba isoforms. Mid kasta oo iyaga ka mid ah fuliya hawlihiisa. enzyme noocan oo kale ah (Cox) waxay keentaa falcelin kiimikada ah taasoo keentay in ugu acid arachidonic galaa prostaglandins, thromboxanes iyo leukotrienes.

Cox-1 ayaa masuul ka ah wax soo saarka ee prostaglandins. Waxay ilaaliyaan caloosha ka saamaynta xun saameyn ku leh hawlaha of platelets, iyo raadka uu isbeddel ku yimaado qulqulka dhiigga kelyaha.

Cox-2 waa sida caadiga ah ka maqan oo waa caabuq gaar ah enzyme dhexsameeysmo dhex cytotoxins, iyo sidoo kale dhexdhexaadiyayaal kale.

tallaabo noocan oo kale ah ee NSAIDs sida Iscelin of Cox-1, xanbaarsan yahay hannaanka ah dhibaatooyin soo raaca.

horumar cusub

Waa wax qarsoodi ah ee diyaarinta ah jiilka koowaad ee NSAIDs leeyihiin saamayn xun ku xabka gastric. Sidaa darteed, saynisyahano dhigay gool - si loo yareeyo saamaynta aan loo baahnayn. nooc ka mid ah in la sii daayo cusub loo sameeyay. In daawooyinka sida qayb firfircoon waa baqshada gaarka ah. kaabsal waxaa loo sameeyey qalabka sida in aadan baabbi'isaa deegaanka acidic ee caloosha. Markaasay waxay bilaabeen inay kaliya burburto markii ku dhuftay in mindhicirka. Waxaa macquul ah in la yareeyo saamaynta ay diiqayo on xabka gastric. Si kastaba ha ahaatee, qaab dhaawac derbiyada mareenka caloosha iyo mindhicirka xun uu weli sii raagayaan.

Tani waxay keentay in farmashiye ku dhexsameeysmo xarunta cusub. daawooyinka Previous ay yihiin hab aasaas kala duwan ee ficil. jiil cusub oo NSAIDs lagu gartaa saamayn doorashada Cox-2, iyo sidoo kale Iscelin ee wax soo saarka prostaglandin. Tani waxay kuu ogolaanaysaa inaad si ay u gaaraan oo dhan saamaynta loo baahan yahay - xanuunka, qandhada, anti-bararka. Xaaladdan oo kale, jiilka ugu dambeeyay ee NSAIDs si loo yareeyo saamaynta ay ku xinjirowga dhiigga, shaqada dhiig xinjirowga xabka gastric.

saamaynta anti-bararka sabab u permeability hoose ee derbiyada vascular, iyo sidoo kale hoos u dhac in guud ahaan dhex dhexaadiyayaal kala duwan bararka. Sababo la-gaadhista this la yareeyo cuncun ee receptors dareemayaasha xanuunka. Saameynta xarumaha thermoregulatory gaar ah ee maskaxda, u ogolaan jiilka ugu dambeeyay ee NSAIDs waa u fiican in ay hoos u heer-kulka guud.

Tilmaamayaasha

Si weyn loo yaqaan saameynta NSAIDs. Saamaynta daroogada sida loogu talagalay ka hortagga ama dhimista soo geedi socodka bararka. daroogada waxay bixiyaan ah saamayn qandhada aad u fiican. saamaynta ay jirka la leh saamaynta barbar dhigi karaa analgesics maandooriyaha. Intaa waxaa dheer, waxay ku siin xanuunka, saamaynta ah anti-bararka. NSAIDs gaaro oo baaxad weyn oo ay goob daawayn iyo nolol maalmeedka. Maanta waa mid ka mid ah daawooyinka caafimaad ugu caansan.

Saamaynta wanaagsan waa xusay on arrimaha soo socda:

1. Cudurada of nidaamka muruqyada. At murgacashada kala duwan, burbur, xogta daawo arthritis waa fudud maarmin. NSAIDs loo isticmaalo osteochondrosis, arthropathy bararka, arthritis. daroogada waxay leedahay saameyn anti-bararka ee qalooca, saxanno herniated.
2. Xanuun daran. Diyaargaraw arrin si guul leh loo isticmaalay calool u biliary, cudurada jirrooyinka. Waxay la baabi'iyo ka madax xanuun, xataa jaf, raaxo kelyaha. NSAIDs waxaa si guul leh loo isticmaalo bukaanka ee muddada postoperative.
3. heerkulka sare. saamayn qandhada ogolaanaya isticmaalka daroogada ee nno nooca kala duwan ee dadka waaweyn iyo carruurta. daroogada waxay dhaqan galaysaa xataa qandho.
4. formation Thrombus. NSAIDs jira daawooyin antiplatelet. Tani waxay u ogolaaneysaa iyaga si aad u dalbato in ischemia. Waxay yihiin qiyaas ka hortagga wadne iyo stroke.

kala soocidda

About 25 sano ka hor, waxa loo qorsheeyay 8 kooxood oo ah NSAIDs. Maanta, tirada in ay kor 15. Si kastaba ha ahaatee, tirada saxda ah dhakhaatiirta xitaa loo yaqaan laga qaadin. Muuqday suuqa, si deg deg ah ku guuleystay caan baahsan ee NSAIDs. Diyaargaraw xilka analgesics opioid'ka. waxay Sababtoo ah, ka duwan ee la soo dhaafay, ma ha ka cadhaysiinina murugada neefsashada.

kala soocidda ee NSAIDs ku lug qaybsameen laba kooxood:

1. daroogada Older (jiilka kowaad). Qaybtan waxaa ku jira daroogada loo yaqaan, "Tsitramon", "aspirin", "Ibuprofen", "naproxen", "Nurofen", "Voltaren", "Diklak", "diclofenac", "indomethacin", "Movimed", "Phenylbutazone" .
2. NSAIDs New (jiilka labaad). In ka badan 15-20 sano ee la soo dhaafay, Farmashiiste ayaa sameeyay wax soo saarka aad u fiican, sida "Movalis", "Nimesil", "Nise", "Celebrex" "Arcoxia."

Si kastaba ha ahaatee, tani ma aha soocidda kaliya ee NSAIDs. daawooyinka cusub ee qarnigan kala qaybsan yihiin taagayo non-acid iyo acids. Markii hore, ka fiirsan category dambe:

1. Salicylates. Kooxdani waxa ay ka kooban daawooyin NSAID ah, "aspirin", "diflunisal," "Lizinmonoatsetilsalitsilat".
2. Pyrazolidine. Wakiilada of this category ka mid ah daroogada waa "phenylbutazone", "azapropazone", "oxyphenbutazone."
3. Oxicams. Kanu waxaa weeye qarnigii ugu cusub cusub ee NSAIDs. List of daroogada: "piroxicam" "Meloxicam", "Lornoxicam", "tenoxicam". Daawooyinka ma yihiin cheap, laakiin ay saamayn on jidhka ka socdaa inta badan muddo ka badan NSAIDs kale.
4. taagayo acid Phenylacetic. koox ka mid ah NSAIDs noocan oo kale ah waxaa ka mid ah macnihiisu yahay "diclofenac", "tolmetin," "indomethacin", "Etodolac", "Sulindac," "Atseklofenak".
5. Daawooyinka anthranilic acid. Wakiilka ugu weyn ee daawo "Mefenaminat".
6. Means of Propionic acid. Qaybtan waxaa ku jira NSAIDs qurux badan. List of daroogada: "Ibuprofen" "ketoprofen" "benoxaprofen", "fenbufen," "fenoprofen," "tiaprofenic acid", "naproxen", "Flurbiprofen", "pirprofen," "nabumetone".
7. taagayo acid Isonicotinic. daawo Main "Amizon".
8. daroogada pyrazolone. Si this category iska leh habka si fiican u yaqaan, "Analgin".

By non-acid taagayo ka mid ah sulfonamides. Kooxdan waxaa ka mid ah daroogada, "Rofecoxib" "Celecoxib", "Nimesulide".

waxyeellooyin

jiil cusub oo NSAIDs kor ku xusan, saameyn wax ku ool ah oo kala duwan oo jidhka ah. Si kastaba ha ahaatee, iyagu ma ay saameyn ku yeelan hawlaha of mareenka caloosha iyo mindhicirka. Kala daawooyinkan waa meel kale oo wanaagsan: jiilka cusub ee NSAIDs aadan haysan saameyn aad u ba'an ku unugyada carjawda.

Si kastaba ha ahaatee, xataa sida hab wax ku ool ah oo awood u xanaajin, tiro ka mid ah Waxyeellooyin. Waa in ay ogaadaan, gaar ahaan haddii daawada loo isticmaalo waqti dheer.

Cilladaha ugu waaweyn waxaa ka mid noqon kara:

• wareer;
• dawakhsanaan;
• madax-xanuun,
• daal,
• wadno,
• cadaadis sii kordhaya;
• neefta, in yar neef,
• qufac qalalan,
• cudurada dheefshiidka,
• borotiin laga helo kaadida;
• falgalka beerka kacsantahay,
• finan maqaarka ah (buundo);
• dareeraha;
• xasaasiyadda.

Xaaladdan oo kale, burburka xabka gastric aan arkay gelitaanka ee NSAIDs cusub. Daawada waxa ma keeni sii daridda ah ee boogaha dhiig.

Talooyin ku saabsan isticmaalka

The daroogada fiican anti-bararka leeyihiin phenylacetic acid, salicylates, pirazolidony, oxicams, alkanones, daawooyinka of acid Propionic iyo sulfonamide.

From xanuun wadajir ah ugu wax ku ool ah la baabi'iyo daroogo "indomethacin", "diclofenac", "Ketoprofen", "Flurbiprofen". Tani waa NSAID ugu fiican osteochondrosis. The daawooyinka ku xusan kale oo aan ahayn "ketoprofen" diyaarinta hantiyi kaga hadlay saamaynta anti-bararka. oo macnaheedu yahay "piroxicam" dhicin this category.

analgesics wax ku ool ah ay yihiin daawooyinka "Ketorolac" "Ketoprofen", "indomethacin" "Diclofenac".

Hogaamiyaha ayaa ka mid jiilka ugu dambeeyay ee NSAIDs ahaa daroogada "Movalis" ah. Qalabkani waxa uu la ogol yahay in aad dalbato muddo dheer. daawooyinka anti-bararka jira daawooyin analogs wax ku ool ah "Movasin", "Mirloks", "Lem", "Artrozan", "Melox", "Melbek", "Mesipol" iyo "Amelotex".

Drug "Movalis"

daroogada waxaa laga heli karaa sida kiniinno, dabada iyo malawadka xal maamulka muruqyada dhexdooda. Wakiilka loola jeedaa taagayo enolovoy acid. Lagu gartaa xanuunka u fiican daroogada iyo guryaha qandhada. Waxa la ogaaday in geedi socodka dhammaan bararka daawada keenaa saamayn ah ku yeelan.

Tilmaamayaasha for isticmaalka daroogada waa osteoarthritis, spondylitis ankylosing, rheumatoid arthritis.

Si kastaba ha ahaatee, in ay ogaadaan in ay jiraan sababo in wakiilada ka heli:

• diidmo in qayb ka mid ah daawada;
• Cudurka mid qoon leh in marxaladda ba'an,
• dhantaalan kelyaha ee daran;
• dhiigbaxa boog;
• failure cagaarshowga daran;
• uurka, naas-nuujinta;
• wadnaha daran.

Ha qaadan carruurta daroogada ilaa 12 sano.

bukaanka Adult kuwaas oo laga helay osteoarthritis, maalin walba lagu taliyey by 7.5 mg. Haddii loo baahdo, dose this kordhin kara 2 jeer.

In rheumatoid arthritis oo caadi maalin spondylitis ankylosing waa 15 mg.

daryeelka xad dhaaf ah waa in ay qaataan daawada in bukaanka u nugul ah ee waxyeellooyin. Dadka ayaa muujiyay la'aan kelyaha iyo kuwa on kelyaha, waa inay qaataan wax ka badan 7.5 mg inta lagu jiro maalinta.

Qiimaha daroogada "Movalis" in loox oo 7.5 mg, № 20 waa 502 rubles.

opinion Consumer ku saabsan daawada

Reviews of dad badan oo ku xiran yihiin xanuun aad u daran, ayaa muujinaya in daawada "Movalis" - aalad ugu fiican ee la isticmaalo muddada-dheer. Waxa si fiican loo dulqaatay by bukaanka. Intaa waxaa dheer, in ay joogaan dheer ee jirka waxay suuro gelineysaa in dose hal daawo. factor A aad u muhiim ah, sida uu sheegay inta badan macaamiisha, waa in la ilaaliyo carjawda, maxaa yeelay, daroogada ma laha saamayn taban iyaga on. Waa arrin aad u muhiim u ah bukaanada ayaa loo isticmaalaa hab ee osteochondrosis, arthrosis.

Intaa waxaa dheer, daroogada waa fiican ka badbaadisaa xanuun kala duwan - kedisa, madax xanuun. Fiiro gaar ah u bukaanada liiska cajiib ah waxyeelo. Inta aad qaadato daawada NSAID ah inkastoo ay digniin soo saaraha, aan adag cawaaqib xun.

Drug "Celecoxib"

tallaabada of qalab this waxaa loogu talagalay yaraynayo xaaladda bukaanka la osteochondrosis iyo arthrosis. Daawada si fiican yahay meesha xanuun, wax ku ool ah oo Fayda Xumaanta geedi socodka bararka. waxyeello ka soo gaartey oo ku saabsan nidaamka dheefshiidka loo aqoonsaday.

Tilmaamayaasha ay u isticmaalaan la siiyo in buuggan waxa ay yihiin:

• arthritis psoriatic ;
• osteoarthritis,
• arthritis rheumatoid;
• spondylitis ankylosing.

samaynta waxa uu leeyahay tiro ka mid ah sababo. Intaa waxaa dheer, daroogada aan loogu talagalay carruurta ka yar 18 sano. taxaddar gaar ah waa in la ilaaliyaa dadka qaba cudurka wadnaha iyada oo loo adeegsanayo kordhaya nuglaato in dareeraha.

Qiimaha daroogada kala duwan taas oo ku xidhan baakada, aagga of 500-800 rubles.

opinion macaamiisha

dib u eegista waxay jeelyihiin in is burinaya oo ku saabsan dawadan. Bukaanjiifka qaar sababta oo ah xarunta this ku guuleysan karo xanuun wadajir ah. Qaar kale ayaa sheegaya in daroogada ma caawin. Sayidka, hab tani ma aha had iyo jeer ku ool ah.

Intaa waxaa dheer, waa in aynaan qaadan daroogada naftooda. In qaar ka mid ah dalalka Yurub dawadan waa ka mamnuuc, sababtoo ah waxa ay leedahay saamaynta cardiotoxicity, taas oo ku filan qalbiga ku xun.

Drug "Nimesulide"

Dawadani waxay ma aha oo kaliya waxay leedahay saameyn anti-bararka iyo antipain. Means wuxuu leeyahay sifooyin antioxidant in la xakameeyo walxaha daroogada in baabbi'in carjawda iyo collagen macdantaa.

Codsatay daawaynta for:

• arthritis;
• arthritis;
• osteoarthritis,
• myalgia;
• arthralgia;
• bursitis;
• qandho,
• syndromes xanuun kala duwan.

Xaaladdan oo kale, saamaynta xanuunka daroogada bixisaa si dhakhso ah. Caadi ahaan, bukaanku uu gargaar 20 daqiiqo ka dib markii uu qofku cuno gudahood. Taasi waa sababta qalab waa mid aad waxtar u leh xanuunka paroxysmal ba'an.

Ku dhawaad mar kasta, daroogada waxaa si fiican loo dulqaatay by bukaanka. Laakiin mararka qaarkood, waxaad la kulmi karaan dhibaatooyin soo raaca sida dawakhaad, la qabsi, madax xanuun, lalabo, laab, hematuria, oliguria, urtikaria.

Qalab looma ogola in ay helaan haweenka uurka leh iyo carruurta jirta ilaa 12 sano. daryeelka gaarka ah waa in ay qaataan daawada dadka "Nimesulide" kuwaas oo arkay hypertension, shaqada kelyaha oo yaraada, aragtida ama wadnaha.

daroogada Price celcelis ahaan 76,9 rubles.

Maxaad samaynaysaan oo macaamiisha?

Reviews of diyaarinta had iyo jeer waa ay wanaagsan tahay. Tan iyo daroogada uu yahay xanuunka iyo yaraynaysaa qandho, dagaal weyn caabuq.

Bukaan badan ayaa sheegay in calaamadaha gargaarka dhacdaa si deg deg ah oo ku filan, iyo muddada ay tallaabo ku saabsan yahay siddeed saacadood.

qalab aad u fiican si fiican meesha ilig, argagaxa leh, xanuun arthritic. Daawada caawin kara raaxo la'aanta ay sababtay xannibmi karo dareemayaasha.

Drug "Ksefokam"

daroogada waxaa ka mid ah oxicams kooxda. Kooxdaan duwan NSAID kordhay bar-nolosha, taasoo keentay in soo-gaadhista daroogada daba dheeraaday. Waxaa si weyn u dhimay inta jeer ee aad hesho medicament. Sidaas awgeed, halista waxyeellooyinka waa la dhimay.

Drug "Ksefokam" waxaa ka mid ah awoodda ugu sarraysa xanuun si ay uga soo. Its saamaynta xanuunka on daliilka xoog u dhigma morphine. Si kastaba ha ahaatee, ka duwan dambaysta ah, qalab ma aha qabatimo oo uusan saamayn ku lahayn habka dhexe ee neerfayaasha.

Inta lagu jiro baaritaanka, waxaa la arkay in daawada xanuunka 12 saacadood.

Qiimaha daroogada qaab kiniin (8 mg) № xirxiraan 10 waa 205 rubles.

Drug "Rofecoxib"

daroogada waxay leedahay xanuunka anti-bararka, qandhada iyo saamaynta anti-edematous. Xilsaaray hab wax ku ool ah ee cudurrada soo socda:

• periarthritis chronic;
• arthritis rheumatoid;
• gaaray bowdada;
• bursitis;
• dhaawacyo soo gaaray seedaha, muruqyada.

Waxaa ku filan in ay si waxtar leh loo baabi'iyo daroogada "Rofecoxib" kala duwan ee calaamadaha xanuun sababa neuralgia, osteochondrosis, minbarka. Waxaa loola jeedaa si fiican u yareeyaa lumbago, si kedisa, syndrome radicular.

Daawada waa in aanay noqon xiran inuu aqbalo by bukaanka qaba neef, ka dib markii wadno xanuun, stroke. Ma aha lagama maarmaan in la isticmaalo, iyo dadka qaba cudurada oncological, hypertension iyo atherosclerosis. Daawada waxaa ka mamnuuc caruurta ka yar 12 sano. Intaa waxaa dheer, ka hor inta aadan isticmaali waxaa lagu talinayaa in si taxadir leh ka fiirsan dhibaatooyinka suurogal.

Drug "Parecoxib"

Tani waa hab aad u fiican by kaas oo ah in la yareeyo jawaabta bararka iyo qayb ka qaadanaysa yaraynta of dareen of receptors xanuun. Daawada waa in baahida bukaan qaliin.

Waxa ay meesha syndromes xanuun ah oo dhexdhexaad ah in ay xoogga daran. Maamulo kadib markii hip total iyo bedelka jilibka, hysterectomy, qalliinka wadnaha hawlbowlaha, loo isticmaalo si dhab ah ilkaha.

sixitaanka Qiyaasta waa Gaarna shakhsi. Waxay ku xiran tahay xaaladda caafimaad iyo tilmaan. Carruurta ka yar 18 sano daawo looguma talagalin.

Drug "Arcoxia"

Daawada leeyahay magac kale - "Etorikoksib". hab waxaa lagu gartaa antiinflammatory, guryaha xanuunka sare. diyaarinta kor u Iscelin of Suu xanuunka.

Bukaanka qaba cudurada nidaamka muruqyada oo gargaar ka qalab this takhaluso qallafsanaan subaxdii. Waxa ay soo hagaagtay dhaqdhaqaaqa wadajirka ah, yaraynaysaa xoogga barar ah, si fiican u gargaartay by xanuun. Marka la helo saamaynta ay ku daweyn dhacdaa afar iyo labaatan daqiiqo gudahood. The walax daroogada firfircoon si fiican u nuugo by dhiigga. Diyaarinta waxa lagu gartaa bioavailability sare. index Tani waa 100%.

Qiyaasta ee dawada la qori karaa oo kaliya by dhakhtarka. Waxaa si caadi ah u dhaxeysa 60 mg ilaa 120 mg maalmo.

Daawada waxaa aan loogu tala galay in loo isticmaalo haweenka uurka leh iyo carruurta ka yar 16 sano.

gunaanad

Farmashiiste Modern aan weli taagan. Horumarinta ee cusub, NSAIDs wax ku ool ah. List of kale oo aan ahayn jiil cusub oo daawooyin, kor ku xusan, wuxuu kuu ogolaanayaa inaad doorato aalad ugu fiican ee heley kasta. Si kastaba ha ahaatee, in ay ogaadaan in daawooyinkan ma awoodaan inay bogsiiso cudurka. Waxay leeyihiin oo keliya saamayn anti-bararka iyo xanuunka.