"Zanidip": tilmaamaha loo isticmaalo, bukaanka dhabta ah iyo dhakhtarro dhigooda. "Zanidip-Rekordati": guide, dib u eegista, analogs

Sida laga soo xigtay tirakoob, oo ku saabsan 26% dadka waaweyn ee dunida si joogto ah la il daran cadaadis dhiig oo sareeya. Inta badan cudurkan waxa uu la xidhiidhaa cabista hidde. Si kastaba ha ahaatee, waxaa jira sababo kale oo ay u dhacdo. Kuwaas waxaa ka mid cayilka, sigaarka, qaadashada xad-dhaaf ah oo cusbo, la'aanta xubno ka raad iyo fitamiinada ku jira jirka, ku xadgudubka qamriga, stress, dhaqdhaqaaqa jirka hooseeyo, iyo kuwa kale.

Sidoo kale waa in la ogaadaa in horumarinta hypertension ku xiran tahay da'da qofka. The ka weyn uu yahay, waxa sii badanaya halista ah ee sida gobolka bahal ah. At da'da 40 sano, cudurka had iyo jeer waa natiijada lesions vascular sclerotic.

warbixin guud

Inta badan, dhakhaatiirta saaray bukaan cudurka "hypertension muhiim ah". Waa maxay? Waa cudur joogto ah oo nooc ka mid ah dhiig-karka. Uu calaamad weyn ee caafimaad oo u dhaqmo quruxsan joogto ah oo sii dheeraaday ee cadaadiska dhiigga.

Isbedelada ee cudurka sida laga yaabaa kala duwan. Si kastaba ha ahaatee, waxay ugu horayn la xiriiraan xididdada dhiigga iyo wadnaha.

Si loo hagaajiyo xaaladda bukaanka, dhakhaatiirta ku talinaynaa daroogada this sida "Zanidip". Reviews bukaanka on waxtarka daawada laga wada hadli doonaa in qalabka of this article. Sidoo kale waxaa jira waxaad ka heli doontaa macluumaad ku saabsan sida si ay u helaan sheegay daawo, haddii uu wax analogues iyo waxyeelo.

Description, halabuurka, qaabka iyo baakadaha

medicament "Zanidip" Waxbarashadu waxa lagu kaydiyaa xidhmada baakadaha laga saaro qaab kiniin Nuur noocyo huruud ah oo ku wareegsan iyo biconvex ganaya on mid ka mid ah dhinacyada ku. Waxay yihiin-dahaarle oo ay leeyihiin towns ah hurdi nasashada.

Walaxda firfircoon ee daroogada this dhaqmo hydrochloride lercanidipine. Sidoo kale, waxaa ka mid ah iyo qaybaha kaabayaal, taas oo ay matalayaan sida K30 povidone, laktosmonohydrat lactose, sodium noqde carboxymethyl, cellulose mikrokristallin iyo milmahayn magnesium.

Iyadoo la tixgelinayo samaynta film-daahan, ka dibna waxa uu ka kooban yahay walxo sida Opadry Yellow, Rusheyn kartaa, hypromellose, titanium dioxide, xabagta bir dheeh jaalaha ah iyo macrogol 6000.

Iibso kiniinka "Zanidip" in baakad fin laga yaabaa, in lagu dhejiyay in sanduuqyada warqad.

sifooyinka pharmacological daroogada

Ma ogtahay in uu yahay maandooriye "Zanidip"? Tilmaamaha on codsiga muujinaysaa in ay tahay xanibaha channel calcium la'ahay. Its qayb firfircoon waa isku dar ah racemic ah stereoisomers dextro-iyo levorotatory. Sidoo kale waa in la ogaadaa in ay tahay derivative ah 1,4-dihydropyridine.

medicament Tani eegista xanibeen hadda udhigo calcium unugyada wadnaha, unugyada vascular iyo muruqyada siman.

Mabda'a ah saamayn joogta ah antihypertensive daroogada waxaa sabab u saamayn relaxant toos ah unugyada muruqa siman vascular.

Sida laga soo xigtay tilmaamaha, ka dib markii la helo saamayn ku daweyn of medicament la gaari 5-7 saacadood ka dib. Muddada ay ansax la hayo maalintii oo dhan.

Sababo la selectivity sare ee daroogada si uu unugyada muruqa siman vascular, waxa aanu u leeyihiin saamayn taban inotropic.

Waa maxay daroogadu "Zanidip-Rekordati"? Guide sheegayaa in ay metabolically daawo dhexdhexaad ah oo aan saamayn badan ku content ee apolipoproteins iyo Lipoproteins ee serum dhiig aan xaq u leeyihiin, iyo sidoo kale aysan waxba ka beddelin profile baruurta ee dadka qaba dhiig-karka.

The kinetics daroogada

Halkee nuugo daroogada "Zanidip"? Tilmaamaha loogu isticmaalo noo sheegi doonaa in ka dib markii la helo kiniinka (10 ama 20 mg) hoosta lercanidipine ku dhowaad si buuxda u nuugo ka soo mareenka caloosha iyo mindhicirka. 1.5-3 saacadood fiirsashada ugu badan ee daroogada ee plasma dhiigga Kadib gaadho qiimaha a of 3.3 ng / ml ama 7,66 ng / siday u kala horreeyaan ml.

Qaybinta daroogada ee unugyada iyo xubnaha qaadataa meel si degdeg ah. Isgaarsiinta la borotiinada plasma ka badan 98%. kiniiniyada dose si isdabajoog ah ay raasamaal lagu arkay.

-shiid ee daroogada waxaa lagu fuliyaa inta lagu guda jiro pass ugu horeysay iyada oo beerka. Tani waxay dhacdaa by CYP3A4 biotransformation. Tani waxay abuurtaa tiro ka mid ah metabolites aan lahayn hawlaha pharmacological.

daawo soo bandhigay "Zanidip", dib u eegista ah oo lagu soo bandhigay wax yar ka hooseeya iyada oo mindhicirrada iyo kelyaha. Waxaa jira laba weji ka saarida lercanidipine: hore, kuwaas oo muddo yahay 2-5 saacadood oo final ah - 8-10 saacadood.

Daawada bedelin waa ficil ahaan lama dareemo ee saxarada iyo kaadida.

Dadka qaba beerka ama content protein cudurka kelyaha ee plasma waxaa si weyn u dhimay. Marka tan la eego, jajabka free ah walaxda firfircoon ee medicament ayaa laga yaabaa in si weyn kor ugu.

Tilmaamayaasha si aad u hesho daawo

Waayo, waa maxay ujeedada loo xilsaaray karaa daawo "Zanidip"? Reviews dhakhtarro sheegay in wakiilka this wax ku ool ah laftiisa muujinayaa in hypertension muhiim ah oo khafiif ama dhexdhexaad ah saxariirinta.

Sababo si ay u helaan Alwaaxdii

Sida laga soo xigtay tilmaamaha, daroogada "Zanidip" Waa in aan loo qaadan hoos shuruudaha soo socda:

• shaqada beerka oo daran;
• dabeecadda wadnaha chronic (gaar ahaan tallaabo decompensation);
• dhantaalan function kelyaha,
• angina deganayn ,
• isku dhafan oo inhibitors xoog isoenzyme CYP3A4 (tusaale ahaan, "ketokonazol", "erythromycins", "itraconazole") iyo "cyclosporin" iyo juice bambeelmo,
• inta aad uurka leedahay,
• xirma marinnada dhiigga ka soo ventricle bidix ee wadnaha ah,
• lactose, lactase yaraanta iyo nuugeynin syndrome galactose / glucose,
• inta lagu jiro naas-nuujinta;
• dhawaan by Wadnaxanuun myocardial (inta lagu jiro mudada of hal bil);
• Haween ku jira da'dii dhalmada oo aan la isticmaalayo hab la isku halayn karo ee ka hortagga uurka,
• da'doodu ka yar tahay (quseeya ammaanka iyo aan la aasaasay);
• diidmo in lercanidipine iyo taagayo kale dihydropyridine ama qaybaha ka mid ah daawada.

daawo taxadar qaadashada

medicament "Zanidip-Rekordati" digniin waxaa lagula talinayaa in ay qaataan dadka qaba shaqo oo yaraada beerka (dhexdhexaad ah oo khafiif ah), sanka nedostatochnostyusindromom wadnaha chronic, ventricular bidix failure iyo cudurka halbowlaha wadnaha, iyo soo dhaweynta wadajira "Digoxin" beta-blockers.

Kiniiniga "Zanidip": tilmaamaha loo isticmaalo

In view of tiro badan oo ah dhacdooyinkan gurracan ee daroogada loo arkaa waa in ay maamusho shaqaalaha khibrad leh. Sida caadiga ah, daroogada firfircoon waxaa lagu talinayaa in ay qaataan in lacagta ah 10 mg maalintii hal mar.

Kiniinka waa in la fuliyay in subaxdii, waayo, ¼ saac ka hor quraacda.

Iyada oo ku xidhan saamaynta ay ku daweyn of qiyaasta of daroogada hoos tixgelin loo Laab laabi karo, i.e. ilaa 20 mg. qiyaasood oo sii kordhaysa oo ah medicament waa in si tartiib tartiib ah ay dhacaan. Haddii loo baahan yahay, kororka xaddiga medicament fuliyay laba todobaad ka dib ka dib markii bilow ah therapy.

Sidee baan u qaado "Zanidip-Rekordati"? Ha calalin Alwaaxdii. guud ahaan waxay liqay oo la qadar ku filan oo dareere ah maydhay.

In dadka waayeelka ah No sixitaanka qiyaasta loo baahan yahay. Laakiin marka la qaadanayo daawada ay xaalad u baahan tahay la socodka joogtada ah.

In joogitaanka failure cagaarshowga ama kelyaha ama kaabidda qiyaasta darnaanta dhexdhexaad ah looma baahna. In dhowrka maalmood ee ugu daroogada ay maamusho qadarkuu of 10 mg, marka hore, ka dibna si taxadar leh kordhaya qiyaasta ilaa 20 mg maalintii.

Haddii saamaynta antihypertensive waxaa si xoog leh ka muujiyay, qiyaasta ku qeexan waa la dhimay.

waxyeellooyin

waxay keeni kartaa falcelin aan loo baahnayn "Zanidip-Rekordati"? dib u eegista Consumer warran in qaadashada ee taasi ka dhigan tahay waxay inta badan muuqan waxyeelo. Maxaa sax ah, waxaan hadda ka fiirsan:

• Nidaamka Immune: diidmo.
• nidaamka Wadnaha: tachycardia, angina, wadno, suuxid, bafinayo maqaarka wajiga, xabad xanuun, calaamadeeyay hoos u cadaadiska dhiigga, wadna xanuun.
• habdhiska: somnolence, madax-xanuun, wareer.
• mareenka dheefshiidka: matag, dyspepsia, lalabo, kororka karo in ensaymes beerka, shuban iyo calool xanuun.
• Finan maqaarka.
• Nidaamka muruqyada: myalgia.
• Urinary: polyuria.
• Kale: bararka durugsan, daal, kelyaha ciridka, daal.

Calaamadaha badinta

Waa maxay saamaynta ku raacayaa, haddii aad qaadato qaadasho sare ee daroogada "Zanidip"? Guide ku taxan calaamadaha soo socda ee xad dhaafka ah: Wadnaxanuun myocardial, tachycardia reflex, vasodilation durugsan la hoos u dhac wayn ee cadaadiska dhiigga, in la kordhiyo mudada iyo inta jeer weeraro angina.

Si aad u baabi'iyo dalalka sida daaweynta calaamadaha.

isdhexgalka daroogada

waxaa suurtagal ah in lagu biiriyo daawo daroogooyinka kale "Zanidip"? Tilmaamaha loogu isticmaalo muujinaysaa in qalab la reebay in lagu biiriyo inhibitors CYP3A4 sida (P450 cytochrome beerka), sida "Itraconazole" "ketokonazol" iyo "erythromycin". Tan waxa u sabab xaqiiqada ah in daawooyinka oo dhan kordhin fiirsashada of lercanidipine ee dhiigga, sidoo kale hogaanka si saamaynta antihypertensive.

warbixinta soo dhaweynta wadajira waxay ka dhigan tahay in ay "cyclosporin" waa u, sida laga yaabaa in ay u horseedi in la kordhiyo content ee labada walxaha in dhiig bukaan-socodka.

Lercanidipine waa ka mamnuuc in la wada isticmaalo juice bambeelmo. isku darka Tani waxay keeni kartaa in potentiation of saamaynta antihypertensive of lercanidipine iyo Iscelin shiid.

Waa in taxaddar dheeraad inta aad qaadaneyso "Zanidipa" daawooyin sida "Astemizole", "Terfenadine" iyo "quinidine", iyo sidoo kale antiarrhythmics fasalka saddexaad (tus, "Amiodarone").

isku dhafan ee medicament ah loo tixgeliyaa daawooyin anticonvulsant ( "phenytoin," carbamazepine ") iyo" rifamycins "waxaa laga yaabaa in ay gacan ay hoos u dhacday heerka dhiigga lercanidipine, taasoo keentay in hoos u dhac of saamaynta antihypertensive of lercanidipine.

Marka daawada la "Digoxin" waa in si joogto ah loola socdo calaamadaha sarkhaan.

daaweynta isku mar la medicament "midazolam" ee qaangaarnimada kordhin kartaa absorbability ee lercanidipine iyo in la yareeyo heerka nuugista ay.

Khubarada ayaa sheegaya in "metoprolol" waa awood yaraynta bioavailability of lercanidipine 50%. Xaaladdan oo kale, bioavailability ee "Metoprolol" isma badelin. saamayn Tani baxdo ka hoos ee socodka dhiigga cagaarshowga sababa beta-blockers.

Diyaarinta "cimetidine" in qiyaasta a of 800 mg maalin kasta ma keeni in isbedel la taaban karo ee fiirsashada dhiigga lercanidipine ah. Laakiin at its soo dhaweynta waxay u baahan tahay taxadar gaar ah, tan iyo markii qaadasho sare kordhin kartaa bioavailability ee lercanidipine oo sidaas awgeed ay kordhiso saameynta antihypertensive.

Iyada oo isku dhafan ee "Zanidipa" with "dawo" daroogada ugu horeysay in la qaado subaxdii, oo kii labaadna wuxuu ahaa - fiidkii.

The medicament "fluoxetine" saameyn ah kuma laha ee kinetics of lercanidipine.

soo dhaweynta wadajira "Zanidipa" with "warfarin" ma saamayn ku pharmacokinetics doonana.

Lacagtaas lagu dari karaa diuretics, beta-blockers iyo celiyeyaasha ACE.

Sidoo kale waa in Waxaan la soco ethanol oo kor lekarnidipina hawlgeli antihypertensive.

talooyin gaar ah

Drug "Zanidip", analogues ah kuwaas oo hoos ku qoran, waa in ay si taxadir leh u daran ahaan dadka qaba shaqada kelyaha daciif ah iyo cudurka halbowlaha wadnaha, sida ay dhacdo in this, waxaa jira halis weyn oo ah kaadida oo soo badata weeraro angina.

Ka hor inta aan la helo daawada waa in had iyo jeer la magdhow wadnaha oo shaqadiisa gaba dabiiciga ah ee joogtada ah.

taxaddar gaar ah waa in la arkay bilowga ah ee daaweynta, gaar ahaan dadka qaba degree dhexdhexaad ah oo khafiif ah kaafi cagaarshowga.

Inta lagu jiro daaweynta, waa la jecel yahay in ay si taxadar leh u fuliyaan shaqo u baahan in fiiro gaar ah, oo ay ku jiraan maamulka waddooyinka. Tan waxa u sabab xaqiiqada ah in bilowga ah ee daaweynta iyo qaadasho xad-dhaaf ah waxaa jira halis ah oo dhacdo ee madax xanuun, hurdo iyo wareer.

xaaladaha kaydinta, nolosha shelf oo ka mid ah diyaarinta iyo iibka

Halkee ayaan ka iibsan kartaa kaniiniga "Zanidip-Rekordati"? Analogs lacagaha isaga qudhiisa ku daawada lagu iibiyo farmashiye kasta. Si kastaba ha ahaatee, ay laga iibsan karaa oo kaliya on warqad dhakhtar ee.

dawadan hay gaari suurad wacan loogu talagalay carruurta yaryar, halkaas oo heerkulka kama badna 30 digrii.

Nolosha shelf ee daroogada ka yar tixgelin waa saddex sano. Mudadaas ka dib, daawo qaadashada waa ka mamnuuc.

analogues daroogada

Ma la socotaa waxa aad ka bedeli kartaa kiniiniga "Zanidip"? Analogues qalab this waa kuwo ku adag in la helo. Khubarada sheegaan in guryaha iyo shaqada diyaarinta sida la mid ah hantidaan sida "Lerkamen" iyo "Lercanidipine". Qaadashada daawooyinka, kuwaas oo waa in ay ahaataa oo keliya talo caafimaad.

Drug "Zanidip": dib u eegista bukaanada iyo xirfadlayaasha

Waa wakiilka antihypertensive aad wax ku ool. In view this waxaa la wadaago by dhakhaatiir badan. Waxaan ku heshiiyaan iyaga la, iyo ku dhowaad dhammaan bukaanada qaadashada kaniiniga "Zanidip". Waxay ku andacoodeen in ka dib markii qaadashada daawada xaaladda ay sicad hagaagtay. Calaamadaha hypertension lagama maarmaanka ah waa darnaanta fudud iyo kuwa dhexdhexaadka ku dhowaad si degdeg ah ka tago.

khasaare kaliya ee daawada this waa in aad inta badan qaadato keena waxyeelo, gaar ahaan qayb ka mid ah marinka dheef shiidka iyo nidaamka wadnaha iyo.

Sidoo kale waa in la ogaadaa in dad badan oo ka caban ku saabsan qiimaha daroogada waa mid aad u sareeya. daroogada Tani waa in xaddiga 28 xabbo oo kiniin laga iibsan kartaa 450-500 rubles. Waa in la ogaadaa in analogues of medicament sheegay in qaab "Lerkamena" iyo "lercanidipine" ma jaban. Waxay waxaa laga iibsan karaa isla qiimaha.

Khubarada ayaa sheegaya in qiimaha "Zanidip" daroogada antihypertensive si buuxda u waafaqsan tayada. Waxa ay muujinaysaa in ku dhawaad oo dhan ee uu waayo-aragnimo dheer ee codsiga.