Daawada "Doxorubicin": diiwaanka, dib u eegista, photos, foomka sii daayo, qiyaasta, kaydinta. "Doxorubicin-Lance": tilmaamaha loo isticmaalo

kansarka waa mid aad khatar u ah nolosha aadanaha. Waxay ka kooban tahay unugyada faafeen malignant iyo caasiyoobay, oo ay awoodaan in ay dhex gasho galay nudaha ku hareereysan iyo metastasize in xubnaha kale.

Horumarinta ee daroogada iyo daaweynta cudurada sida waa hawl muhiim ah. Nasiib darro, ilaa hadda ma jiro mid ka mid ah ilaa iyo dhamaadka anigoo aan go'aansaday. Inkasta oo ay wali jiraan daawooyin u dhigi kartaa heerka unugyada burada. Mid ka mid ah iyaga ka mid ah soo gudbiyey daawada "Doxorubicin". Tilmaamaha loogu isticmaalo iyo sawir a of daroogada lagu dabooli doono qodobkan. In waxa aad ka heli doontaa macluumaad ku saabsan sida loo sii sheegay in hab kaas oo ay u sameeyaan waa la heli karaa for sale, iyo in ka badan.

Baako, halabuurka, qaabka iyo description

In waxa foomka lagu iibiyo "Doxorubicin"? Tilmaamaha loogu isticmaalo tilmaamaya noocyada soo socda ee wax soo saarka:

• Lyophilizate diyaarinta of xal la isku duro intravascular iyo intravesical. Waa mass furan cas-jaalle ah oo ka kooban walaxda firfircoon sida hydrochloride doxorubicin. maaddooyinka Sida dheeraad ah oo isticmaalaya mannitol. Daawada lagu iibiyo dhalooyin, ku lifaaqan ee kartoon ah.
• Fiiro-saarka leh xal isku duro intravascular iyo intravesical. Waa dareere cas oo hufan taas oo ka kooban hydrochloride doxorubicin wuxuuna ku qoran yahay dhalooyin iyo kartoonada.

Farmashiiste ee daroogada

Waa maxay daawada sida "Doxorubicin"? Tilmaamaha (foomka fasaxa ee daroogada ayaa lagu kor ku xusan) la isticmaalo ayaa sheegay in ay tahay antibiotic anthracycline anti-buro ah, kaas oo uu go'doonka ka ah dhaqamada of fungus Streptomyces peucetius ah. Waxa uu awoodaa inuu ku isticmaali saamaynta antimitotic iyo antiproliferative.

La macaamilka DNA, medicament ah uu hakiyo polymerase RNA, DNA polymerase iyo topoisomerase nooca 2, iyo sidoo kale shidaa soo saarka ee xagjirka lacag la'aan ah iyo u dhaqmo on derbiga unug. Sidaas darteed of saamaynta sida yaraysa taranka DNA iyo noolaha Avv acid nucleic.

Waa wax aan macquul ma ah in la ogaado xaqiiqada ah in aan ku fekereyno hab uu leeyahay saamayn cytotoxic toos ah. Unugyada muujiyaan dareen gaar ah ay u daroogada ee G2-waji iyo S-waji ah ee noloshooda.

guryaha ogeed

Maxaa xuduudaheedu ogeed soo jireenka ah ee daroogada "Doxorubicin"? Tilmaamaha loogu isticmaalo sheegayaa in ka dib markii la isku duro xididka, qalab had iyo jeer qaybiyey multiphase. Inta lagu jiro 5 daqiiqo ee ugu horeysay ee medicament ah si degdeg ah ka qabsadeen nudaha, iyo ka-fiirsashada ee dhiiga si degdeg ah hoos. Sida for wajiga labaad, waxaa la fuliyay taagoo daroogada gaabis ka unugyo ah.

Xoogga daroogada firfircoon ee beerka, kelyaha, caajisnimo, sambabada iyo myocardium. Waxa kale oo guskiisa mandheerta iyo saxarrada la caanaha naaska.

Response to borotiinada plasma dhacdaa by 75%. Dheef-daroogada ee beerka, oon la xirrira derivative firfircoon sida doxorubicinol.

The ereygu ensaymes geedi socodka dib u soo kabashada ee xagjirka lacag la'aan waxay saameyn kartaa horumarinta sumoobo wadnaha.

Half-nolosha ee doxorubicin iyo doxorubicinol la mid ah oo ay ku saabsan tahay 20-48 saacadood.

Ku dhowaad 40% ee qiyaasta of daroogada la wada daayay la bile, iyo% of doxorubicin iyo taagayo ay kaliya 6-11, muddo 5 maalmood ah waxaa laga helaa kaadida.

Tilmaamayaasha

daroogada "Doxorubicin" waxaa laga yaabaa in loo magacaabo at cudurada maxay?

Tilmaamaha loogu isticmaalo (kansarka kaadiheysta waa hab loo adeegsado marar aad u badan) waxa uu sheegayaa in daawada u qabata iyo sidoo kale marka:

• kansarka qanjirka thyroid, Kaposi iyo Ewing,
• buro Wilms ', kansarka gastric, foomka unugyada yar ee kansarka sanbabada,
• insulinoma, kansarka naasaha, mesothelioma;
• kansarka esophageal, carcinoid, neuroblastoma;
• sarcoma osteogenic, hepatocellular carcinoma hoose, lymphoma Hodgkin ;
• Kansarka qanjirka 'prostate', kansarka madaxa iyo qoorta, thymoma malignant,
• kansarka ilmo galeenka, noocyo ka mid ah burooyinka Testicular;
• sarcoma, makaanka, gooba cadeymaha kansarka, cudurka Hodgkin;
• rhabdomyosarcoma, leukemia ba'an;
• leukemia lymphocytic chronic, myeloma.

sababo

Waa kuwee dhigayaa diidina bukaanka in uu magacaabo daroogada ah "Doxorubicin"? Tilmaamaha loogu isticmaalo, kansarku dhabta ah ayaa sheegaya in qalab aan daliil aad wax ku ool in:

• wacyigelin si doxorubicin ama waxyaabaha kale ee daroogada, iyo sidoo kale wakiilo ka anthracyclines iyo anthracenediones;
• therapy ka hor, ama xubnaha kale ee anthracenediones anthracycline ee qiyaasood oo yareysey, iyo sidoo kale beerka (daran), Wadnaxanuun myocardial, garaaca, cudurada viral ba'an iyo wadnaha (maamulka gale);
• burooyinka halista ah, germinating derbiga kaadi haysta, cudurada kaadi mareenka iyo cystitis (waayo, intravesical).

Iyada oo taxaddar, daroogada waa in la isticmaalaa dadka helay chemotherapy degdegga ah, iyo sidoo kale sababaha halista cardiotoxicity ah, xad gudub ku ah beerka, lafaha dhexgalka dhuuxa unugyada kansarka iyo buurnaanta.

Intaa waxaa dheer, si taxadar leh loo arkaa daroogada la qoray ee carruurta iyo dadka da'da sare, iyo qayb ka mid ah a multi-noocyada iyo therapy antitumor multicomponent.

Drug "Doxorubicin": tilmaamaha loo isticmaalo, qiyaasta

Sida laga soo xigtay tilmaamaha, tixgeliyaa daroogada intraarterially loo qaadan karaa, intravenously iyo intravesically. Sidoo kale waa in la ogaadaa in qalab waxaa loo isticmaali doonaa waallayn ama isku dhafan oo daroogo kale cytostatic in qaadashada kala duwan.

xal daroogada socodaan "Doxorubicin" waa in la isticmaalaa isla markiiba ka dib markii ay soo saaridda.

dejinta duridda xididdaha

At qiyaasta lagula taliyey of monotherapy "Doxorubicin" halkii wareegga waa 60-75 mg / sq. m saddex toddobaad kasta. Sida caadiga ah, daroogada waxaa lagu duraa mar. Si kastaba ha ahaatee, dose this lagu maamulo laga yaabaa iyo irbado badan (qadarkuu of 25-30 mg M maalintii / sq. For 3 maalmood ee ugu horreeya wareegga).

Si loo yareeyo saamaynta ay sun ah habka maamul ee loo isticmaalo todobaadle ah 10-20 mg / sq. m jeer toddobaadkii.

Marka lagu daro wakiilada kale anticancer medicament firfircoon waxaa maamula in wareegga qiyaasta ah ee lacagta ah ee 30-60 mg / sq. m 4 toddobaad kasta.

koorsooyin si isdabajoog ah daaweynta fuliyay oo kaliya ka dib markii tirtiridda dhammaan calaamadaha sumoobo.

Qiyaasta guud ee daroogada waa in aanay noqon in ka badan 550 mg / sq. m.

Maamulka Intra-halbowlaha ah wakiilka ah

Sidee waa duray intra-halbowlaha "Doxorubicin" daroogada? Hagaha wadamada in ay u siiyaan dadka sidetone kansarka medicament firfircoon hepatocellular in loo maamulo si ay halbowle guud cagaarshowga in qiyaasta a of 35-150 mg / sq. m. At muddooyinka waqti isku mid ah u dhexeeya wareegyo waa loo siman yahay 3 asbuuc ilaa 3 bilood.

hordhaca ah ee daroogada geliyo kaadi haysta

Sida kaadi durayaa daawada "Doxorubicin-Teva"? Tilmaamaha loogu isticmaalo ayaa sheegay in qiyaasta taasi ka dhigan tahay maamulka intravesical waa in 35-50 mg halkii loo xirxiro.

nidaamka Medical waa in la fuliyo dura 7-28 maalmood, taas oo ku xidhan ujeedada (ka hortagga ama daaweynta).

Fiirsashada of xal daroogada waa in ay ahaataa 1 mg / 1 xal biyo ml ama jireed.

Ku keento waxaa la sameeyaa 2 saacadood gudahood. Marka ay dhamaato ee bukaan-socodka waa in faaruqiso kaadi haysta.

waxyeellooyin

Diyaarinta "Doxorubicin", oo edbinta kor lagu sharaxay waxay keeni kartaa dhibaatooyinka soo socda:

• matag, calool xanuun, lalabo, ulcerös, stomatitis, shuban, esophagitis, hyperpigmentation xabka afka, anorexia, kor u fiirsashada bilirubin dhiigga, dhiig-bax iyo mindhicirka, kor u transaminases cagaarshowga;
• karo leukopenia, Torombositobiiniya, dhiig yari, leukopenia, neutropenia dose-tiirsan,
• tachycardia sanka, block atrioventricular, foomka tachyarrhythmia failure gabsiiya wadnaha, bradycardia, thrombophlebitis, uu block laan xidhmo, aan caadi ahayn on ECG, arrythmia ventricular, lungemboli, phlebitis, dhibaatooyin thromboembolic;
• amenorrhea, oligospermia, hyperuricemia, xayd kaadi cas, azoospermia;
• conjunctivitis, keratitis, lacrimation;
• neurotoxicity durugsan, qalal, kooma,
• barar, alopecia reversible, photosensitivity, hyperpigmentation skin, rash, itching, urticaria xanuun severe, EPIDERMIS erythema wet;
• dermatitis, finan, bronchospasm, barrar maqaarka, anaphylaxis;
• phlebitis Local, caabuq calaamadeeyay, fleboskleroz, thrombophlebitis, xanuun maxaliga ah, galleeyda nudaha,
• polyuria, Nocturia, gubta, galleeyda xuubka kaadi, hematuria, raaxo, kaadida oo daran;
• striation erythematous goobta la duray;
• daal, qidmeyntiibulshada, qandho, qarqaryo, horumarinta lymphocytic ama leukemia myelocytic (acute), hyperuricemia, baddu, nephropathy;
• boog 12 dyspepsia / gastric, sclerosis biliary.

calaamadaha xad dhaafka ah

Waa maxay calaamadaha ah qiyaasta xad dhaafka dhacaan marka aad isticmaasho tiro badan oo ah "Doxorubicin" daroogada? Tilmaamaha Isticmaalka sheegaysaa in xad dhaafka ah ee lacagta u horseedi kartaa calaamado sun yihiin muujiyey by habka dheef shiidka, iyo sidoo kale in myelosuppression daran. Intaa waxaa dheer, qaadasho sare ee daroogada wuxuu noqon karaa mid fudud si ay keeni cudurka wadnaha ee daran.

le ah si ay daroogada "Doxorubicin" kajirin. In xad dhaafka saameeyeen maamula therapy astaamaha. Sidoo kale, waxaa isbitaal oo waxaa lagu daaweeyaa daawooyin lid ku ah bakteeriyada.

isdhexgalka daroogada

waxaa suurtagal ah in lagu biiriyo daroogooyinka kale daroogada "Doxorubicin"? Tilmaamaha loogu isticmaalo muujinaysaa in marka aad isticmaasho qalab this isku dhafan oo daroogo kale cytotoxic inta badan muujiyey ay sumoobo daro.

Marka daroogada isku dhafan oo daroogo kale cytotoxic, kaas oo ay leeyihiin cardiotoxicity (tusaale ahaan, "Fu" ama "Cyclophosphamide") a, wuxuu u baahan yahay la socodka taxaddar waxyaalaha qalbiga ku jira inta lagu guda jiro oo dhan therapy.

"Streptozocin" kordhiyaa badhkiis nolosha "Doxorubicin".

therapy The "Doxorubicin" bukaanka waxaa laga yaabaa in ay muujiyaan calaamadaha cystitis dhiigbaxa ba'an ka dib markii daaweyn "cyclophosphamide", iyo sidoo kale xoojin arrin ku sumoobo beerka ka dib markii daaweyn "mercaptopurine."

Isticmaalka "Paclitaxel" ka hor inta hordhaca ah ee dhabta ah ee "Doxorubicin" cadhaysiiyaan kordhiyo fiirsashada dhiigga dambaysta ah.

Waa maxay daawooyinka waxaa ka mamnuuc ah isticmaalka daroogada "Doxorubicin"? Tilmaamaha loogu isticmaalo (xoolaha lagu qorin) ayaa sheegay in qalab this waa in aan lagu qaso daawooyin kale. Tusaale ahaan, waa pharmaceutically la jaan qaada ah "heparin", "Dexamethasone", succinate sodium, "hydrokortisoni", "cephalothin", "aminophylline", "Fu" iyo daroogooyinka kale anticancer.

Marka lagu daro tallaalka viral live waa taranka viral suurto gal ah iyo kor u reactions dhinaca iyo hoos u ereygu antibody ee jirka bukaanka ayaa jawaab u isticmaalka tallaalka.

talooyin gaar ah oo ku saabsan isticmaalka daroogada

Waxyaabaha aad ogaanaysid ka hor inta la isticmaalayo "Doxorubicin-Lance"? Tilmaamaha loogu isticmaalo waxay muujinaysaa in in koorsada daawada wakiilada antineoplastic lagama maarmaan ah si ay u fuliyaan la socodka joogtada ah ee beerka, sawirka dhiig durugsan, ECG iyo ultrasound waxyaalaha qalbiga ku jira.

xaaladda iibka, habka of kaydinta iyo shelf-nolosha

Halkee waa daroogada "Doxorubicin-Lance"? Tilmaamaha loogu isticmaalo ayaa sheegay in qalab this waa in lagu hayaa meel qalalan oo mugdi ah, halkaas oo heerkulka kama badna shan digrii.

medicament waxaa la sii daayay farmasiyada by qoro oo keliya. Its nolosha shelf waa laba sannadood.

Price iyo analogues

Qiimaha daroogada waxaa loo arkaa 120-150 rubles in 5 ml. Haddii loo baahdo waxaa lagu beddeli karaa by yahay sida "Doxorubicin-Teva", "Lachema Doxorubicin", "Onkodoks 50", "10 Onkodoks", "Doxorubicin-Ebewe", "CRC-Doxorubicin" iyo kuwa kale.

dib u eegista Consumer daawada

Haddaba aad u ogaato sida loo isticmaalo daroogada "Doxorubicin". Tilmaamaha isticmaalka iyo ku keydinta daroogada ayaa kor lagu soo bandhigay.

Waxay jeelyihiin in tiro badan oo ah dib u eegista macaamiisha la xiriira dhibaato halis ah oo dhaca inta lagu jiro daaweynta daroogada. Si saamaynta kuwanu waa ka qaybgalka xubnaha gudaha, muddo dheer xanuun dareemayey, timaha oo daata iyo formation of boogaha goobaha muday.

On fariin wanaagsan ay aad dhif u yihiin. Oo kanu ma aha la yaab, tan iyo waxtarka daawada anticancer waa in la qiimeeyo oo keliya ku takhasusay khibrad leh, oo ku salaysan tiro badan oo ah arrimo kala duwan: nooca monotherapy ama therapy isku dhafan, kansar, xaaladda bukaanka, iyo natiijooyinka kale ee mudada dheer.