Immunoglobulin E iyo muhiimadda nafsaaniga ah

Immunoglobulin E iyo muhiimadda jir - arrimaha oo u baahan tixgelin. Waqtigan xaadirka ah, waxaa jira dhawr nooc oo ah immunoglobulins (antibodies). Waxaa jira dhawr nooc oo ah unugyada kala duwan ee nooca ficilka iyo hab ay ahaasho anti-infective. Unugyada difaaca kaga xanaajiyeen roobab iyo flocculation ee badeecada kala diri bakteeriyada, agglomeration iyo agglutination cudur corpuscular (spirochetes, fayrasyada, protozoa iyo bakteeriyada). Marka trypanosomes vibrios xuub gacanta iyo spirochetes go'an immunoglobulins kaxeynayo gaar ah la dhamaystiro, keenaya adsorption dhiig xinjirowga. Sida caadiga ah, kuwaas oo wakiilada faafa ceshan yihiin in nudaha lymphoid. The immunoglobulins fasalada G iyo M wada jir ah ula complement hydrolyze kartaa spirochetes, trypanosomes, bakteeriyada iyo fayraska.

Saamaynta of antibodies on pathogene waxaa iskuulka laga joojinayaa marka uu galo unugyada, oo ma muujiyaan antigen dushiisa gacanta. Immunoglobulins xoojin kartaa ama wiiqi iska caabin ah difaaca jirka ee u shaqeeyo. adag antigen antibody-taas oo ka kooban xad-antigen ah, u qabata saamayn kobcinaya, iyo dhismaha la xad dhaaf ah unugyada keena saamayn ka soo horjeeda. Inta badan, immunoglobulins waa sababta dhibaatooyin, shalalka iyo xasaasiyad.

IgE uu ku dhexsameeysmo inta badan ee unugyada ee xub-axaleedka of, mareenka calool-neefsashada, iyo sidoo kale in qanjidhada gobolka. Waayo, markii ugu horeysay, sida fasalka u gaar ah oo immunoglobulin E waxaa lagu tilmaamay 1966, iyo 1968, WHO ayaa aqoonsaday fasalka IgE madax banaan immunoglobulins.

class this borotiinada helay aadanaha, iyo koroowga iyo qaar ka mid ah xoolaha shaybaarka. Inta badan oo ka mid ah u taagoo immunoglobulin E lala unugyada waaweyn ee haragga iyo basophils. Tan iyo hoos uruureen xaaladaha immunoglobulin E caadiga ah ee serum dhiigga ah nanograms yar per mililitir ah, fikrad aasaasiga ah ee qaab dhismeedka of Britain this waa la helay oo kaliya ku salaysan daraasad dhowr borotiinada myeloid. heer aad u hooseeya ee immunoglobulin E ee serum cad baxdo ka xaqiiqda ah in ay noqon karto mid "jiidatay" si ay dusha sare ee unugyada iyo si adag ku xidhaan in unugyada waaweyn iyo basophils.

Waxaa la rumeysan yahay in Іg E waa fasalka ugu weyn ee immunoglobulins oo ay soo saaraan unugyada waaweyn iyo basophils in ay ka qayb dareen diidmo oo xasaasiyadeed. Heerka protein this ee serum of bukaanka qaba xasaasiyadda kordhay iyo sida caadiga ah ka badan 350-800 U / mg. Total IgE ay iska caadi in carruurta da'doodu ka yar tahay 12 bilood ilaa 15 U / ml. IgE kaalin muhiim ah ka falcelinta of diidmo degdeg ah. caadi immunoglobulin E ee dadka waaweyn ee u dhaxayn 0 ilaa 120 U / ml.

Sida ay fikradaha casriga ah, shaqada ugu weyn ee immunoglobulin E waa in la ilaaliyo xuubka jirka ee axaleedka sabab u ah hawshooda u ah ee arrimaha degaanka ee plasma dhiigga iyo unugyada effector. Wareer ah ay awoodaan in ay jebiyaan line ilaalinta noqonaya immunoglobulins fasalka A. Ka dib markii in fayrasyo ama bakteeriya dushiisa of unugyada waaweyn xidhxidhaan fasalka gaar immunoglobulin E, iyadoo ay sabab u unugyada waaweyn dhexgalka sida heli signal a in ay sii daayaan of amines vasoactive iyo arrimo chemotactic, taas oo markeeda sababaha loogasoo ee wareegaya fasalka IG ee G, complement, eosinophils iyo neutrophils. factor chemotactic Eosinophilic, kaas oo la sii daayay ka unugyada waaweyn, kor u raasamaal ee eosinophils iyo burburinta Gooryaanka. Waxaa la rumeysan yahay in IgE ku adsorbed on dusha sare ee noole ah, soo jiidata macrophages mahad kooxda Fc-receptors.