"Indomethacin" (kiniin): tilmaamaha loo isticmaalo, dhabta ah

Mid ka mid ah wakiilo ka socda kooxda magnyl daawooyinka anti-bararka waa daroogada ah "indomethacin" (kiniin). Sababtoo ah halka ay anti-bararka, xanuunka iyo saamaynta qandhada ay isticmaalka loogu talagalay daawaynta cudurada bararka, xanuunka, loo yareeyo bararka iyo in la soo celiyo dhaqdhaqaaqa wadajirka ah.

Description of diyaarinta

The qayb weyn ee firfircoon ee daroogada waa indomethacin, taas oo la xidhiidha in taagayo acid acetic indole. Inside medicament baakadaha "indomethacin" sharaxayaa sida xubno guide kiniin la daahan difaac enteric kaas oo u ogolaanaya wakiilka firfircoon in la sii daayo xiidmaha, Goldogob caloosha. Qaabka uu kiniin ku wareegsan, biconvex, hogaanka daboolay madfac light-brown.

Kiniiniga waa qaadashada badan: 25 mg, 50 mg oo 100 mg ah indomethacin. Available in 10 ama 40 gogo 'halkii pack.

Dhammaan foomamka qiyaasta

Intaas waxaa sii dheer oo kiniin ah, waxaa jira noocyo kale oo "indomethacin" diyaarinta loogu isticmaalo afka ah, tusaale ahaan qiyaasta a kaabsal sii daayo joogto ah 75 mg. Waayo, maamulka malawadka, dabada waxaa loo isticmaalaa qiyaasta ah 50 mg. Codsiyada dibadda abuuray cadar 5% iyo 10% iyo 3% gel.

hab of action

medicament waa magnyl antiinflammatory wakiilka tallaabo systemic, taas oo uu leeyahay antiinflammatory, qabooy, xanuunka iyo saamaynta qandhada. Lifaaqsan daroogada farsamo (kiniin) guide "indomethacin" ka kooban sharaxaad ka mid ah ay howlgalka qayb firfircoon ee la xidhiidha hoos u dhac in hawlaha cyclooxygenase of type 1 iyo 2. Taa baddalkeeda, enzyme this leedahay saamayn yar ku arachidonic acid taas oo yaraynaysa in ay diinta ka si prostaglandin. Waxyaabahani waxay keeni barar iyo xanuun.

soo bandhigaa indomethacin antiplatelet saamayn, yaraynta clumping dhiig xinjirowga unugyada dhiigga. Maandooriyaha attenuates xanuun at xanuun wadajirka ah ee gobolka deggan iyo mobile, yaraynaysaa qallafsanaan aroor iyo bararka, waxay kordhisaa baaxada dhaqdhaqaaqa. Action indomethacin golleeyahay in lagu yareeyo bararka. Saamaynta ugu badnaan la siiyo maalinta toddobaad oo daaweyn ah, kiniin daroogada.

in dhaqmo

Iyada oo ku saleysan hab ay of action, "indomethacin" diiwaanka kiniin ku talinaysaa isticmaalka loogu daweeyo systemic ee:

• syndrome articular;
• cudurada bararka nidaamka muruqyada sababa rheumatoid, psoriatic, rheumatoid, dhallinta arthritis, garabka la qaboojiyey, spondylitis ankylosing, cudurka wadajir ah in deforming osteitis iyo uretrookulosinovialnom syndrome,
• cudurada side nidaamka muruqyada sababa osteochondrosis la radicular syndrome, osteoarthrosis kalagoysyada, sinta iyo arthrosis intervertebral mooyee,
• waasac dambidhaafkiisu cudurka, oo daboolaya nudaha connective;
• laabotooyinka,
• lesions ka timaato bararka ee bacaha periarticular iyo seedaha,
• calaamadaha xanuunka ba'an ee dhabarka hoose iyo kuwa kale qaybo ka mid ah lafdhabarta marka neuralgia markeedii iyo dareemayaasha kale, caabuq murqaha;
• caabuq argagaxa leh ee unugyada ama kala goysyada jilicsan.

Waxay kaa caawin kartaa inaad si ay ula qabsadaan madax xanuun, caadada, si kedisa, qaaxada.

Sida wakiilka ah kaabayaal ah cudurada faafa iyo bararka sida pharyngitis, qumanka, otitis isticmaalaa medicament "indomethacin" (kiniin). Tilmaamayaasha ka mid ah daaweynta ee cystitis, adnexitis, prostatitis.

Daawada waa wax ku ool ah waayo saaridda syndrome xummada leh oo la xiriira cudurka Hodgkin, lymphoma, burooyinka xadka-, markii aan ku simaha paracetamol iyo acetylsalisylsyre salicylic acid.

Sida loo qaato

"Indomethacin" dawo ah kiniin waxaa maamula bukaanka ah ee qiyaasta gaar ah ku salaysan heerka uu cudurka. Guud ahaan, dadka waaweyn bilaabaan la helo qiyaas ah 25 mg saddex jeer maalintii cuntada ka dib.

Haddii saamaynta daaweynta waa ku filnayn qiyaasta double la cadeeyay in 50 mg 3 jeer maalintii. dose la oggol ugu badan waa in aan ka badnayn 200 indomethacin mg. Ka dib markii horumar weyn sababa therapy daroogada, daaweynta waa in la joojiyay oo kaliya ka dib 4 todobaad oo isticmaalaya mudo hore ama qiyaas hoos. Haddii bukaanka qaado kaniiniga muddo dheer "indomethacin" diiwaanka ku talineysa qiyaas ah 75 mg ah ee firfircoon maalin kasta.

daaweynta carruurta

Waayo, qiyaasta ilmaha maalin kasta xisaabiyaa by dhufasho 2.5 ama 3 mg on mass jidhkiisa, waxaa la qaato 3-4 jeer. Waayo, koox da 'walba la siiyaa isticmaalka dose hore maalin walba:

• carruurta 3 ilaa 7 sano ay maamulaan ka 50 mg ilaa 75 mg, taas oo u dhiganta 2 ama 3 xabbo oo kiniin,
• caruurta 7 ilaa 12 sano, laga bilaabo 75 mg 100 mg, taas oo u dhiganta 3 ama 4 kaniini,
• Caruurta 12 sano qoray 100 mg ilaa 125 mg, taas oo u dhiganta 4 ama 5 kiniin.

In maalmaha ugu horreeya, waa in aad ogaato sida daroogada jirka ilmaha, sidaas darteed isticmaali qiyaas yar oo ah dawada. Muddada daaweynta la (kiniin) edbinta "indomethacin" tusmeeya sida muddada u dhaxaysa 6 ilaa 7 maalmood.

Features soo dhaweynta

Marka tan la eego, waxaa suuro gal ah waxyeello ka soo gaartey aqbaliddoodii macnihiisu yahay "indomethacin" kiniinada, waxaa wanaagsan in aadan isticmaalin daawaynta qandho rheumatic ba'an ee carruurnimada. Socota caanaha naaska, qayb firfircoon helo dhiigga ilmaha, waxay kordhisaa joonis ee nafsaaniga ah ee ilmaha iyo guuldaradii ee unugyada beerka. Si looga hor, baajiso naas-nuujinta.

Dadka waayeelka ah, dadka qaba beerka buka, kelyaha, shiidka, calaamadaha dyspeptic, hypertension, gabsiiya wadnaha qalitaanka ka dib, cudurka Parkinson, qalalka, uurka leh ee aniga iyo II bilood markii uu u xilsaarayo daaweynta indomethacin ayaa loo baahan yahay si ay ula socdaan xaaladda u shaqeeyo. Waxaa lagama maarmaan ah in la xakameeyo shaqo ee xubnaha dhibaato, mar 7 maalmood oo kasta in la baaro dhiigga durugsan.

Haddii ee la soo dhaafay waa xasaasiyad ku qaba daawooyinka anti-bararka non-steroidal, daroogada "indomethacin" (kiniin) waxaa loo doortay in xaaladaha khatarta ah.

Waxaan ku talinaynaa in aadan qabashada shaqada halista ah ee daaweynta, sida ay hawshu u fiiro iyo psychomotor wareersan.

Marka aadan qaadan karin

Waxaa jira cudurro qabtay oo daawo ahaan uu u "indomethacin" (kiniin). Its isticmaalka suurtogal ma aha:

• diidmo in indomethacin;
• iyadoo ay wada joogaan erosive iyo lesions kolit ee nidaamka dheefshiidka in wajiga ba'an;
• marka "triad aspirin", lagu gartaa dulqaad in acetylsalicylic acid, polyps sanka iyo neefta bronki,
• at hemodyscrasia;
• marka uu dhaco isbedel fahmayaan of beerka iyo kelyaha,
• at dib u dhac ah ee cusbada iyo dareeraha la suurto gal bararka durugsan;
• in qof failure raaga daran ee myocardium ah,
• at cadaadis kacsantahay,
• neefta bronki,
• in caabuq ganaca,
• in III bilood ee uurka ilmaha;
• Naas-nuujinta;
• in carruurta ka yar 3 sano.

dhibaato

Daawada "indomethacin" (kiniin) la xidhiidha laga yaabaa in dhacdooyinkan gurracan ee si xun u saameeya xaaladda jidhka bini'aadamka. Waayo, falcelinta caadiga ah loo kasin waxaa ka mid ah yalaalugo, anorexia, xanuun caloosha, dibiro, calool, saxarada ah.

Marar dhif ah, waxa dhici kara waxyeello erosive iyo lesions kolit, dhiig-bax iyo daloolin ee caloosha iyo darbiyada xiidmaha, applasticheskoy ama anemia hemolytic, leukopenia, Torombositobiiniya, Agranulocytosis, finan, timo ah oo daataan, cuncun maqaarka, qalal, anjioedema, bronchospasm.

Calaamadaha necrolysis epidermal sun ah, oo aad dhif u arkay lama filaan ah anaphylactic, nodosum erythema.

Inta lagu guda jiro daawaynta daciifin laga yaabaa in howlgalka of kelyaha ee excretory iyo beerka, taas oo kordhinaysa xaddiga bilirubin, transaminases cagaarshowga.

Isticmaalka muddada dheer ee daroogada "indomethacin" (kiniin) kama saarayso dhibaato la xidhiidha rabshooyin hurdo, dawakhaad, neuropathy durugsan, madax xanuun, caro, caro, daal. Waxay waxaa lagu gartaa aleelka ee wilka, conjunctivitis ah, maqalka, tinnitus, hypertension, barar.

Reviews

Waxaa muhiim ah in la raaco oo dhan sharciyada daroogada, ka reebid oo dhan sababo.

Ma isku qasan on gelitaanka ee dib u eegista daroogada "indomethacin". Kiniiniga leeyihiin waxyeellooyin badan foomamka qiyaasta loogu isticmaalo dibadda. Intaas waxaa sii dheer, daroogada firfircoon ka Qisoon inhibitors ee cyclo-oxygenase 1 iyo 2, kuwaas oo loo arko inay wax ku ool ah ka yar iyo ka dhigi dhowr ah oo dareen diidmo loo baahnayn of mareenka calool-ka.

Rheumatologists iyo bukaanada ay, dhakhaatiirta qalliinka inta badan daawo cusub kooxda ee oxicams. Waxay la xakameeyo nooca cyclooxygenase 2 keliya, iyada oo aan saamayn ku nooca enzyme 1, kaas oo hubinaya in wax soo saarka ee prostaglandins in ay ilaaliyaan nidaamka dheefshiidka. Taasi waa sababta oxicams samayn doonaa waxyeello ka yar caloosha yahay daawo "indomethacin" (kiniin). Tilmaamo-celin xun waxaa ka mid ah sharaxaad ku saabsan waxyeelo, laakiin tani micnaheedu ma aha in daaweynta ay u baahan yihiin in ay la soo bandhigi. Wax walba waxay ku xiran tahay sifooyinka u shaqeeyo.

Bukaan badan, taas macnaheedu waa lagu badbaadinayo ka dhabar xanuunka, myalgia, neuralgia intercostal, marka daawooyinka kale ma caawin. A saamaynta taban shiidaa ka daaweynta "indomethacin" daroogada ma kici. Reviews kaniiniyada kabsaday bukaanka soo saaray wanaagsan. Inkastoo khatarta mar walba jooga, oo kaliya dhakhtarka qori kara soo dhaweynta ah ee sida daroogada halis ah.

analogs

Kiniiniga la walax firfircoon indomethacin waxa soo saarey shirkado badan oo gudaha iyo midda dibadda, sida shirkadda "Sopharma" ah, "Ludwig Mekle" "Nycomed", "Farmahim", "Berlin Chemie Menarini," "Altfarm". Kaliya daawo kasta magaca ganacsiga ay, ka kooban qaybaha ay kaabayaal ah. All facooda ka muujinaya isku mid ah la isticmaalo, waxyeelo, sababo.

The daroogada ugu caansan "indomethacin Sofarma" (kiniin). Soo saaray in qiyaas ah 50 iyo 100 mg by "Sofarma" (Bulgaria). Waxaa loola jeedaa a daawooyinka anti-bararka non-steroidal.

Labada ciyaaryahan kale oo aan ka yarayn ee analogues yaqaan - daawooyinka "indomethacin 50 mg ah ee Berlin-Chemie" iyo "indomethacin 100 mg ah ee Berlin-Chemie". Soo saaray laba qaadashada (50 iyo 100 mg) by shirkadda Talyaaniga "Berlin-Chemie Menarini".

In diyaarinta "indomethacin" (kiniin) waxay leeyihiin analogues iyo wax soo saarka Ruush. Waxay waxaa laga heli karaa noocyo kala duwan qiyaasta. waa dhigooda oo waaweyn:

• "Indomethacin akar" Chemical-Pharmaceutical Plant JSC "Akrikhin";
• "Indomethacin-Altfarm", LLC "Altfarm";
• "Indomethacin-Biosynthesis", JSC "Biosynthesis";
• "Vero indomethacin", OJSC "Veropharm".